Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 0.0054 1.1 8.8 0.2 67 108 2 58 1 60 0.82

2 4 1.2 2.3e+02 1.2 0.1 76 108 58 90 55 92 0.86

3 4 4.8e-20 9.5e-18 63.7 0.0 9 96 153 240 144 255 0.84

4 4 0.57 1.1e+02 2.3 0.0 76 100 254 278 249 287 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	0.0054	1.1	8.8	0.2	67	108	2	58	1	60	0.82
2	4	1.2	2.3e+02	1.2	0.1	76	108	58	90	55	92	0.86
3	4	4.8e-20	9.5e-18	63.7	0.0	9	96	153	240	144	255	0.84
4	4	0.57	1.1e+02	2.3	0.0	76	100	254	278	249	287	0.79

Coding Sequence: ATGGTACTAAACTACATTTATACCGATCGTATTGATCCTACCAAGAGATCAGACGACAAAGTTGAAGATCCCCAGAGCAACCGTATTGTACTTCTTATGATGGATGTATATCGGCTGGCTGTGCAATTCAATATGAAACGTTTGGAACAATTATGTATCAATTATCTCGAGGCAACCATAAGCCATGCGAACGTTTTGGAAGCATTGCGCAATGCTGTGCATTTGAAATTGTACTTTATAAAAGAGTTTTGTCTCAGCTTTGTTGTAAAggagattaattataatttaatcgtgATGAGTCAAGAATTTGAGACTTTAGATCAACCGTTAATGGTAGAGATTATTAGGCGACGACAAGTACCACAAGCCAGAACTTTTACGAAATGCGAATATGAATCTGTTACTGGAACTAGTCTGGAGCAAGACATGGAAGCGTTTTTGAAAAGCATTGGTCGAGAATTTTGTGATATCACATTGATACTGAACGATACGCCGATACCGGCGCACAAGGCTATTCTCGCAGCGCGATGTAGTTATTTTGAAGCAATGTTCCGATCTTTCATGCCTGAAAATAATACGGTGAACATACAAATTGGTGAAATGATACCGTCGTCGGAATCGTTTCAATCCTTGCTGAGGTATATCTATTTTGCGGACGTCTCGATGCCTCCTGAAGACTCCTTGTATCTATTTACTGCGCCGGTATTTTATGGTTTCACAAATAACCGACTCCAGGCATTTTGCAAACAAAATCTCGAGATGAATGTCACTTTCGAAAATGTTATACAGATTTTAGAAGCAGCTGATAGAATACAAGCTACCGATATGAAGAAATATGCTCTGAATCTGATAGTTCATCACTTTAGCAAGgTTGCCAAGCTTCCAAGATTAAGACAATTAAGCCGCGAACTTTTGTTGGATATTCTTGATGCGTTAGCTGATGAACGCAGCGAAACTAGAACTTGTCAAGATATGACAAATGATTGCTGA
Protein Sequence: MVLNYIYTDRIDPTKRSDDKVEDPQSNRIVLLMMDVYRLAVQFNMKRLEQLCINYLEATISHANVLEALRNAVHLKLYFIKEFCLSFVVKEINYNLIVMSQEFETLDQPLMVEIIRRRQVPQARTFTKCEYESVTGTSLEQDMEAFLKSIGREFCDITLILNDTPIPAHKAILAARCSYFEAMFRSFMPENNTVNIQIGEMIPSSESFQSLLRYIYFADVSMPPEDSLYLFTAPVFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADRIQATDMKKYALNLIVHHFSKVAKLPRLRQLSRELLLDILDALADERSETRTCQDMTNDC

Sequence clustering based on sequence similarity using MMseqs2