Basic Information

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 8.7e-07 0.00026 22.0 0.2 55 108 2 66 1 68 0.88

2 4 0.65 2e+02 3.1 0.1 76 109 66 99 63 100 0.87

3 4 5.5e-18 1.6e-15 58.1 0.0 9 96 164 251 157 266 0.85

4 4 0.52 1.6e+02 3.4 0.1 76 102 265 291 260 299 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	8.7e-07	0.00026	22.0	0.2	55	108	2	66	1	68	0.88
2	4	0.65	2e+02	3.1	0.1	76	109	66	99	63	100	0.87
3	4	5.5e-18	1.6e-15	58.1	0.0	9	96	164	251	157	266	0.85
4	4	0.52	1.6e+02	3.4	0.1	76	102	265	291	260	299	0.79

Coding Sequence: GTTAAACTTAGGGATGCAGTACCAGAAGCTTTTGACAtggttttaaattatatatataccgatcgTATCGATCCAACAAAGAAAATCGAAGATCCTTTAAGCAAcagaattgttttattgatgaTGGATGTGTATCGTTTGGCCGTGCAGTTTAATATGAAACGGCTGGAGCAACTATGTGTTCACTACCTTGAAGCCACCATAAATCATGCTAATGTTTTAGAGGCATTGCACAATGCTGCGCATctcaaattgtattttattaaagagCTATGCTTGAGCTTCGTTGTAAAAGATAGCAATTACAATCAAATAGTTATGAGTCAAGAGTTTGAGTCTTTAGATCAGCCCTTGATGGTAGAAGTAATTAGACGAAAGCAGATGCCACAGACGAAAAATTTCTTGAAACTTTGTTTGATTGATTTAGGATCAGATATGGgAACGACACTTGAGCAAGACATGGAAGCATTTTTAAAAGGTATAGGACAAGAATTTTGTGATATTACTCTACTTCTGGATGGAGTACCAATCCCATCACACAAAGCAGTATTGGCTGCACGCTGTAGTTATTTTGAAGGATTATTCCGATCATTCATGCCTGAAAGTAATACTGTGAATataCAAATTGGAGAAATGATTCCGTCATCGGAATCCTTTGGTTCACTCCTGCGATATATATATTACGCAGACGTTTCTATGCCTCCAGAGgattctctctatctcttcaCAGTTCCAGTTTTCTATGGTTTTACAAACAATCGTTTGCAAGCATTTTGCAAACAAAATCTCGAAATGAATGTTACGTTTGAAAATGTTATACAGATATTGGAGGCTGCAGACAGAATGCAGGCAGTCGATATTAAGAAATACGCTTTGAATCTCATTGTACATCACATTGAAAAggttGTGCGTTTGCCAAGATTAAAGCAGCTGAGTCGTGAGCTTTTGTTGGATATTATCGAAACTATGGCGGATGAGCGTAGCGATACACGAACCTGTCAGGATATGTCGAATGACTGCTGA
Protein Sequence: VKLRDAVPEAFDMVLNYIYTDRIDPTKKIEDPLSNRIVLLMMDVYRLAVQFNMKRLEQLCVHYLEATINHANVLEALHNAAHLKLYFIKELCLSFVVKDSNYNQIVMSQEFESLDQPLMVEVIRRKQMPQTKNFLKLCLIDLGSDMGTTLEQDMEAFLKGIGQEFCDITLLLDGVPIPSHKAVLAARCSYFEGLFRSFMPESNTVNIQIGEMIPSSESFGSLLRYIYYADVSMPPEDSLYLFTVPVFYGFTNNRLQAFCKQNLEMNVTFENVIQILEAADRMQAVDIKKYALNLIVHHIEKVVRLPRLKQLSRELLLDIIETMADERSDTRTCQDMSNDC

Sequence clustering based on sequence similarity using MMseqs2