Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 1.6e-92 1.7e-88 296.0 23.4 43 300 7 262 2 262 0.95

2 3 0.0034 36 2.8 3.9 122 171 262 311 260 315 0.91

3 3 0.062 6.6e+02 -1.4 7.1 194 238 293 336 280 337 0.55

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	1.6e-92	1.7e-88	296.0	23.4	43	300	7	262	2	262	0.95
2	3	0.0034	36	2.8	3.9	122	171	262	311	260	315	0.91
3	3	0.062	6.6e+02	-1.4	7.1	194	238	293	336	280	337	0.55

Coding Sequence: atgattgtaGCTGATGTAAACAGAACTATGAGAGTAACTCCAGATCCAGTGCGTACATCGCGACTTCTTACAAATTCCAATAATTTCCAATCGAGTCGTAGATCCTCAGAAGATTCGTTGGAAGATGCAGGATTATGCAGAGACATTAGgTTGGAATTAAaggaatttgaagaaaaattcagGAAGGCAATGATAGCTAATGCTCAATTAGATAATGAAAAATCATCTTATACTTACCaagttgatttattaaaagataaattggaAGAATTAGAGGAAACGACTATGCAATTACGTAGAGAATTGAGGGAAAAAAATCGAGATGTTGAACAATTGAAACGCCTTAGTCAAAGATTGAAGGAAGATTTAGATATTTGCAGAGCGCAGTTGCTAGAAAGAGATACACTTATACAAgaAAATGGTTTAGTCATTGTTGATAATAAGGAAAGTGAAGATGAGGAGAACGAGAATATGGAAAATGGATTATGTCATAGAAAGAGAGTACTAGTCAGTACAGAAGCTGCAGAATTATTAGAAACAGCTGGTAAAGGTTCATTAGatattcgACTGAGAAAATTTGCATCTGAGAAAAAGGAATTACAAGATGAAATTCGTCATTTAAGATTGGAATTAGAGGAAACTAGAAATCGCTTGAGACCTGAAAAATCATCTGGCTCAATATTAGcAGGTTGTTTATCTGATAGTGAAGATATTCAACGtgaatcaaataaattgttagctgattataaatttaaattacaaaaagcgGAACAAGATATGTCTACACTACAAGCGACAGTAGCTAGATTAGAGAGTCAAGTAATTCGTTACAAATCAGCTGCAGAAGCATCGGAAAAAGCAGAAGATGaattaaaagtagaaaaaaggaaattgcAAAGAGAAgtaAGAGAAACACAAAGTCGAGTAGAAGAACTGGAGACAGCAAACTCCCATCTACAAAGAAGATTGGATAAacttaaaaatgcaaaatcagCTCTTTTGAAAGAGCTTTGA
Protein Sequence: MIVADVNRTMRVTPDPVRTSRLLTNSNNFQSSRRSSEDSLEDAGLCRDIRLELKEFEEKFRKAMIANAQLDNEKSSYTYQVDLLKDKLEELEETTMQLRRELREKNRDVEQLKRLSQRLKEDLDICRAQLLERDTLIQENGLVIVDNKESEDEENENMENGLCHRKRVLVSTEAAELLETAGKGSLDIRLRKFASEKKELQDEIRHLRLELEETRNRLRPEKSSGSILAGCLSDSEDIQRESNKLLADYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRETQSRVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2