Basic Information

Gene Symbol
Aef1
Assembly
GCA_963082735.1
Location
OY720431.1:7459176-7459808[+]

Transcription Factor Domain

TF Family
zf-GAGA
Domain
zf-GAGA domain
PFAM
PF09237
TF Group
Zinc-Coordinating Group
Description
Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.00094 28 6.6 0.5 13 46 75 107 66 110 0.79
2 4 6.7e-06 0.2 13.5 0.0 21 52 110 141 107 143 0.89
3 4 0.0023 70 5.4 0.1 21 51 138 168 135 169 0.87
4 4 6.1e-05 1.8 10.4 0.1 21 47 166 192 163 197 0.89

Sequence Information

Coding Sequence
ATGACTAATTGTGAAATCGTTATCGTTGCTACAACTGATGAACCAGCAACAGATTTGCAAATCCCCTTCAACGTGATAACCTCAGCGGCAACAGTTTCAGCGGCTGGTGCCACCACTACGACTCATCACCTCGCTCCACTGCAACTTACCGAACAGCAGCAATTGCTGCAGCCAGAAACTCTCCAACAGCAAGTGCAAGCAGGGACACTACCGCCGCATTTGGATCGTCCGCCAACTAACGGTCCCGAGAAGCCATTCCAATGCAATATTTGTGAACGAAGATTTCGACAGTTGAGCACACTAACGAATCACGTGAAAATTCATACCGGCGAGAAACCCTACAAATGCACGATCTGCGACAAAACCTTTCGGCAATCGAGCACCCTTACAAATCACATGAAAATCCACACCGGCGAGAAACCATTCATCTGCTCGTACTGTCCCAAGCAGTTTCGTCAGCTAAGCACGCTCACGAATCACCTGAAAATCCATACCGGAGAAAAACCATTCGAATGTGCCGTCTGCAAAAAACAATTCCGCCAATCGAGTACGCTCAACAATCACATAAAGATCCATGTAATGGACAAGGTATATATAccaataaaaatcaaaaccgAAGAGGACGAAGGATGA
Protein Sequence
MTNCEIVIVATTDEPATDLQIPFNVITSAATVSAAGATTTTHHLAPLQLTEQQQLLQPETLQQQVQAGTLPPHLDRPPTNGPEKPFQCNICERRFRQLSTLTNHVKIHTGEKPYKCTICDKTFRQSSTLTNHMKIHTGEKPFICSYCPKQFRQLSTLTNHLKIHTGEKPFECAVCKKQFRQSSTLNNHIKIHVMDKVYIPIKIKTEEDEG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01223723;
90% Identity
iTF_00672533;
80% Identity
iTF_01223723;