Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.1e-22 4.8e-18 67.4 4.0 225 300 1 71 1 71 0.94

2 3 0.0033 74 4.4 3.2 122 171 71 120 69 123 0.91

3 3 0.065 1.5e+03 0.1 6.6 195 238 103 145 92 146 0.58

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.1e-22	4.8e-18	67.4	4.0	225	300	1	71	1	71	0.94
2	3	0.0033	74	4.4	3.2	122	171	71	120	69	123	0.91
3	3	0.065	1.5e+03	0.1	6.6	195	238	103	145	92	146	0.58

Coding Sequence: CTGAGAAAGTTTGCATCCGAAAAAAAAGAGTTACAAGACGAGATTAGGCATCTCAGGTTAGAGTTGGAAGAAGCAAGGAATCGAATGAGGCCAGAAAGATCCTCAGGTTCTATTCTGGGTATATCAGATTCAGAAGATGCTCAAAGGGAAGCTAATAAACTCTTAGCGGATTATAAGTTTAAGTTACAAAAGGCAGAACAAGACATGTCAACTCTTCAAGCAACCGTTGCGAGGTTGGAAAGTCAAGTAATCCGCTATAAATCAGCAGCCGAAGCTTCTGAAAAGGCCGAAGATGAGTTAAAAGTTGAGAAGAGAAAATTACAAAGAGAGGTTAGGGAATCACAGGGTCGAGTCGAGGAATTGGAAACGGCAAATTCACACTTGCAACGGCGCTTGGACAAACTGAAAAATGCTAAATCAGCTCTCTTAAAGGAACTTTGA
Protein Sequence: LRKFASEKKELQDEIRHLRLELEEARNRMRPERSSGSILGISDSEDAQREANKLLADYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRESQGRVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2