Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 5.3e-25 1e-20 75.9 2.1 222 300 9 82 7 82 0.90

2 3 0.0096 1.8e+02 2.8 3.2 123 171 83 131 81 135 0.85

3 3 0.052 1e+03 0.4 7.1 195 238 114 156 101 157 0.53

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	5.3e-25	1e-20	75.9	2.1	222	300	9	82	7	82	0.90
2	3	0.0096	1.8e+02	2.8	3.2	123	171	83	131	81	135	0.85
3	3	0.052	1e+03	0.4	7.1	195	238	114	156	101	157	0.53

Coding Sequence: atgttttttaaattttatgctTCAGATGTGAGACTGCGAAAGTTTGGAGCTGAGAAAAAGGAAATGCAAGACGAAATTCGACATTTGAGGCTAGAATTAGGAGAAGCAAAAAGTCGCATTAGAAACGAACGTTCTGGGtcaattttaggCTGTTTCTCGGATTCGGATGACGTACAAAGAGAAGCGAATAAACTGTTAGCGGATTACAAGTTCAAGCTTCAAAAGGCGGAACAGGACATGTCGACTATGCAAGCGAATGTCGCGAGGTTGGAGAGTCAAGTCATAAGGTACAAATCGGCCGCGGAAGCATCCGAAAAAGCCGAGGACGAGCTTAAAGTGGAAAAACGAAAACTGCAACGAGAAGTTCGCGAATCTCAAGCCCGCGTGGAAGAACTGGAAACAGCCAACTCGCACTTGCAGCGGAGATTAGACAAATTGAAAAACGCGAAATCGGCCTTGCTCAAAGAACTCTGA
Protein Sequence: MFFKFYASDVRLRKFGAEKKEMQDEIRHLRLELGEAKSRIRNERSGSILGCFSDSDDVQREANKLLADYKFKLQKAEQDMSTMQANVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRESQARVEELETANSHLQRRLDKLKNAKSALLKEL

Sequence clustering based on sequence similarity using MMseqs2