Basic Information

Gene Symbol
-
Assembly
GCA_949715065.1
Location
OX454270.1:22107686-22113981[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 3.9e-06 0.00056 20.8 3.6 1 23 209 231 209 231 0.98
2 14 0.0004 0.057 14.5 3.7 1 23 237 259 237 259 0.97
3 14 0.001 0.15 13.2 1.8 1 23 347 369 347 370 0.94
4 14 1.4e-05 0.002 19.0 1.5 1 23 403 425 403 425 0.98
5 14 0.27 38 5.6 1.8 2 23 443 464 442 464 0.91
6 14 0.029 4.1 8.6 0.1 2 23 475 497 474 497 0.91
7 14 7.4e-05 0.01 16.8 2.1 1 23 504 526 504 526 0.98
8 14 0.016 2.3 9.4 4.3 3 23 533 553 532 553 0.93
9 14 0.0061 0.86 10.7 0.0 3 23 560 580 558 580 0.95
10 14 1.7e-05 0.0025 18.7 0.2 1 23 596 618 596 618 0.98
11 14 0.00013 0.018 16.0 0.2 3 23 626 646 624 646 0.97
12 14 1.3e-05 0.0018 19.2 0.1 1 23 652 674 652 675 0.95
13 14 0.00043 0.06 14.4 1.6 1 23 689 711 689 711 0.96
14 14 8.1e-06 0.0011 19.8 0.1 2 23 986 1008 985 1008 0.96

Sequence Information

Coding Sequence
ATGGACACTGACTTTGTGGAAGATATCGGGTCCATCCATTCTGATAGTCAAATGCTTGATTTCGATAGAacggataatattttatgtccGGATGGTGTTGGTAACTCTAATATCAAGACTGAATATTTCAATGCGGACGACATTGATGATGCTTTGTCGTCTGACAATTGTATTGTACAAACCATTGAGTCTTCATATTTCACACACAGTGGTACACGCAAAAATGAGCTTAACAATATGACCAGAGCAGTTATGGAATCTGTGCCATATGCTGATGGATTGCAATATTTAGCTGCCATATCTTCATTCAGTGATAATTATAAGGAAATGGATCAAGTTCAAGGAATTAAGCAAGAACAAGTTGATCACAGAGGTCTGTTTGAATCTAGTGATGAAGAAGTTCAGCAGTTGAATCAGGAGGAATTTCAAGATTATTTTGATGTCCAAGAAGAAGTTGTAGTTCAAGAATGCCCTGAGCAAGAAGTTATCACTCAAAGTTGGGATGTTGATTGTTCTACCAATATTGACTccaTACTAGACGCAGAAGTTGAATGTATGTCATCAACAGTAGATGTTGATATACCTATACCTGAAGGTGAAGAAGCCTCGTCTTCTGTAAATCCATATCCATGTGATTTTTGTAGTAGGAGGTTTAATCGAAAATCACATCTTATGAATCATATGGTTACTCATCAGTCAGAACGACCTTTTTGTTGTGCATTATGTGGTGTTCGTTATCGACGTAAATGTGATTTAGCTAATcatatgaaaatacatatagGCCCTGATAATTTATCAGAGAATGGTATAGaTAATCAAAATTCATCTGTCTCCAAAGCAATGAACAAATTAATGTTTATGGACCCAATTCAAAGAAGAAGTGTTACCCCAGGTGAAGATTCTGAAGATAAAGAGGACTCATATCAggaacaaaatacaaaaaatagaaGTCGACGAGGCCGGGGTAGAGGTAAAGGTCGTCCAATGAAAGATCGTTTACTAACACTTGGTTGGAATTCAGAAATATATTCCAAACCACATACTTGTAACCCATGCGGGATTTCATTTACCCGTGAAAAAGCTCTTCTTAATCATGCTCGTCTTCACCATATAGACGATGgtgtaaatattgttactaCTCAAAAAAGTAATTCAGACAGTTATGAGCTTACCATAGTGGCAAACTCTCAACAAAATGATGTTAGTTATTCATGTGATTCATGTGGAGCAGTTTTCACCAGATTTGACTTTTTAAAACGGCATCAAAgGCAGCATATGAAAAAAGAACTAGGAAATGTAGAAGAAGAAGTTTATGAAGAGGCTCATATGTGCATACATTGTGGATTGTTCTTCAAGTCTATGCCAGAGTTAGAACTACATACTGAGCAACATTTGGTTCCTACAAATATTCcagaaaaatcaaaatgtttagCTTGTGGTGAAACATTTGATAGTACAGATGAATTGTCTGACCATGTGTCTCAAATGCATACTGGTACTTTACCTGAATATTCATGTAAACTTTGTGGAAAACAGTGTAAAGATGATAAAGCTCTCCAAAAACATTTGATGGTACATGATACATctgataataaatgtataatgtgcaGTAAAAGATTTCATTCTAGAGCAAGACTTAAGCGacataTGATAACTCATAGAGAAAAAGGAGTTATTTGTGATATATGTGGTGAAGAAGTAGCTGATAAACGAGCTCTAATGAATCATAAAGCAAGCCACGCAAACACTGTTAGTGTTTCACGAACTTCTCTTACAGAAAAAGTATTTCCTTGTACAAGTTGtggaaaaGTGTTTGGATCTAGGTCATCCCAACAAATACACATAAGAATACATACAGGTGAGCGACCTTATGGTTGCAGATATTGTGACAAAGCTTTTGCTGATGGTGGTACACTTAGAAAACACGAAAGAATACACACGGGAGAAAAACCATATGCTTGTCCTGTTTGCCCCAAAGCATTTAATCAAAgagttgTATTACGTGAGCATATACGAGCACATCATGCTGGAACTGAGGCAAGGGGAGGACAACAAGTTAGTTTTTATGAGTGTAAAGTATGTGGTTATTTGTTCCGATCTTCCATGGAGCTTTGTTCACATTTAGTACAACATAGTGATGATAATACTGCAAAGTCTAGAGTAGTTCCtgtTGGACCTCGAAAATATAAACGCCGCAGCAAATTGGGTAATCGAAAAAATACATGGTGTTTAGTAGAAAAAGTTTTTACAGTGTTGTCAGATCCGTCTGACACGGAGAGTTGTGAAGATGAACCTACAATGCCTACAGCAGAAGAGCAAGCTGTACAGTCAATTATGGAAGAGaatgatgaaattaaatattgtccCGAGACTAGTCCGAGTAAGTCTCCAGTTAAAACATATAAGATTGTTAATGGTAAATTGGTGAAACATGAACTAAAGTCTTCTAAGCAAGTGTCAAGTGGATCAAAATATCCTACTGTCAAATCTGACCCTTTACCAAAAAAGCAAAGCTTTGTTCTTAAAGATGGTGAATGCACTAGAACATGTCCGaccgttttttattattcttcaaGATCAGATCCAACAGCTATTGAATCATCATTTGGAGAAGAGTCCAAAGAAAATGATAATCCAGACGATGCTGATGATCAGATATCTGTAGAAGATATGGATTTATCAAATATCAAGATTGATTCAAATGAACAGTCacaatttgaaacaaatatCTATAATGATATGTGTAATATTGAGTATACTGATCAAGGAgaagttgaatattatattcagaATGATGGTGAATTTGGTAcgcaagaaaatataatattggaaaCTCCAAATGATGATTGTTTGATTGAGACTGAACTTGTATTTGACACAGATTATGTTGAAGAGGTTGGTGCTAACATTGAATTGAGCACTGAAGAAATGGCACCTGTTTATGCTGAAATTATTTCTTGTGATATTTGCGATGAAATATTTGAGGATAGAAAAGATCTTATGAGACATATTCAAACTATGCACATtggataa
Protein Sequence
MDTDFVEDIGSIHSDSQMLDFDRTDNILCPDGVGNSNIKTEYFNADDIDDALSSDNCIVQTIESSYFTHSGTRKNELNNMTRAVMESVPYADGLQYLAAISSFSDNYKEMDQVQGIKQEQVDHRGLFESSDEEVQQLNQEEFQDYFDVQEEVVVQECPEQEVITQSWDVDCSTNIDSILDAEVECMSSTVDVDIPIPEGEEASSSVNPYPCDFCSRRFNRKSHLMNHMVTHQSERPFCCALCGVRYRRKCDLANHMKIHIGPDNLSENGIDNQNSSVSKAMNKLMFMDPIQRRSVTPGEDSEDKEDSYQEQNTKNRSRRGRGRGKGRPMKDRLLTLGWNSEIYSKPHTCNPCGISFTREKALLNHARLHHIDDGVNIVTTQKSNSDSYELTIVANSQQNDVSYSCDSCGAVFTRFDFLKRHQRQHMKKELGNVEEEVYEEAHMCIHCGLFFKSMPELELHTEQHLVPTNIPEKSKCLACGETFDSTDELSDHVSQMHTGTLPEYSCKLCGKQCKDDKALQKHLMVHDTSDNKCIMCSKRFHSRARLKRHMITHREKGVICDICGEEVADKRALMNHKASHANTVSVSRTSLTEKVFPCTSCGKVFGSRSSQQIHIRIHTGERPYGCRYCDKAFADGGTLRKHERIHTGEKPYACPVCPKAFNQRVVLREHIRAHHAGTEARGGQQVSFYECKVCGYLFRSSMELCSHLVQHSDDNTAKSRVVPVGPRKYKRRSKLGNRKNTWCLVEKVFTVLSDPSDTESCEDEPTMPTAEEQAVQSIMEENDEIKYCPETSPSKSPVKTYKIVNGKLVKHELKSSKQVSSGSKYPTVKSDPLPKKQSFVLKDGECTRTCPTVFYYSSRSDPTAIESSFGEESKENDNPDDADDQISVEDMDLSNIKIDSNEQSQFETNIYNDMCNIEYTDQGEVEYYIQNDGEFGTQENIILETPNDDCLIETELVFDTDYVEEVGANIELSTEEMAPVYAEIISCDICDEIFEDRKDLMRHIQTMHIG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_01347450;
80% Identity
-