Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 0.23 4.3e+03 -0.3 0.1 29 38 147 156 113 159 0.76

2 2 1.7e-15 3.1e-11 45.0 0.0 4 75 188 252 185 254 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	0.23	4.3e+03	-0.3	0.1	29	38	147	156	113	159	0.76
2	2	1.7e-15	3.1e-11	45.0	0.0	4	75	188	252	185	254	0.89

Coding Sequence: ATGGATACCGTGAGCCTCTACACCACTGTGGCGAAATTGCGACAGTTTATTGGCTATGTAGGCAAGTGGTGGACGTCGAAGGTGATGCAAGTGGACGCGTCGCTGGCGCTGATTAAGCTGGCGGGCGACCGGCTGGAGTGGATCTACCGCGGCTCCACGCGCCTGGCGCCGCTCTACCTGGAGCTGCAAGCCGCTGAGCGGCACCGTACCCGCCCCATGCCCAGGTCGGGCCCGCAGCACCGGACTAACATGCCGTACGTGGAATACACCCGCTACGATGAGGAACAACCTTCTAAACCACCTGCAGCACAAACGCCGCAACAAAATGAAGAGATTCGTCGTCAACGCGCCGTGGCCAAGAAGTCTACGGTGACGAGCCAGCCGCCGGCGCCCGTGCCCGTGCCCGCGCCGCCCAGCAGCGCCGCTAACTTGGACAACGTCACCAGCCGAGTTGTGTATTACACGCCCAAGAATGCAATACGCCCGCACAAGATGGTGCCGCATACCTGCGGACCGAAATGCAGGCGCACAGACGTGTTGGCGCTCAAAGACCTACGCACGTACAACCCCTTGGCTAAGCCATTGCTCAGTGGCTGGGAAAGGCAAATCGTACGCTTCAAGGGGCACAAGGAGGTGATGTACCGCGCGCCGTGCGGGCGGCGGCTGCGCTGCATGCCCGAGCTGCACCGCTACCTGCGCGCCGTGCGCTCCGACCTGTCCGTCGACCTGTTCGACTTCGCGCCCGCCACGCACTGCCTCGCCGAGTTCGTGCTCAACAAGTGCCTCGTCGGCAAGAAGGTCCACACACCGCAACGTCACGAACTCACGACACCCCAACAGCACGACATCACGACGCCACAACAACACGATATCACGATACCACAAAGTCATGACGTTATAATATCACGACGTTTTAACATCACGATACCACAATATCACGACGTGATAACATCACGACACGACGACATAATATCACGATACCACAACATCATGACGACATCACATCACGATACCACAACATCATGA
Protein Sequence: MDTVSLYTTVAKLRQFIGYVGKWWTSKVMQVDASLALIKLAGDRLEWIYRGSTRLAPLYLELQAAERHRTRPMPRSGPQHRTNMPYVEYTRYDEEQPSKPPAAQTPQQNEEIRRQRAVAKKSTVTSQPPAPVPVPAPPSSAANLDNVTSRVVYYTPKNAIRPHKMVPHTCGPKCRRTDVLALKDLRTYNPLAKPLLSGWERQIVRFKGHKEVMYRAPCGRRLRCMPELHRYLRAVRSDLSVDLFDFAPATHCLAEFVLNKCLVGKKVHTPQRHELTTPQQHDITTPQQHDITIPQSHDVIISRRFNITIPQYHDVITSRHDDIISRYHNIMTTSHHDTTTS

Sequence clustering based on sequence similarity using MMseqs2