Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_963668995.1
Location
CAVLGL010000115.1:42585474-42604267[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.3e-16 4e-12 47.5 0.0 5 64 758 816 754 850 0.90
2 2 3.2 3.8e+04 -3.7 0.0 44 64 1145 1163 1145 1167 0.78

Sequence Information

Coding Sequence
ATGGCAGTTAAAAAGTGTTGTATTGAAAACTGCCACTCATGTTCAACTAGAAAAGAAGATAAAGGTGTGACATATCACAAGTATCCTAAAGATTTATCTTTACGCACCAAATGGATATCTGTTACACGGCTCAAACACTTTGACGTAGGAACAACCTCATATGTGTGTTCCCGTCACTTTTGTAAAAGTGACTTCCAAGTTTACAAGgactctaaatatattttaaagtcaGATGCTGTACCATCAATTTTTACTTGGGCTATAGAATTATCAAATATGGATTCCAATATAGCAAATGCGCAATCAgttgaaaatataaaagatttatcATCAAGCAGTAAAGAGTCAGAACCTGAAAATTTAGATGCAATTAAAAAGTTTATAGAGGACCAAGAAAAAGAGATACAGGAGCAGAAATGTGAGGGTAAACATTCAATGTTAGAAGATCAAATTAATACAGACATGAGTCAAGTCAAAGAGGAACTTCCAGAGTGTAAAAAGCAAGAGGAAACTTTAGCTGTAGCCACTAGTGTAATGGACCTAATATTAAATGAATCAGAGACACGAATCTTATCTAAAAAAGAAGACACAGAATGCCTTAGTGCTGCTAAAAGAGgtaatagtacagctttgacagttggttctaaAGTTGAAGCAAAGGATTTTGGAGAATTTTGGTATCCAGCTCAAATTGTTGAGGTAGATTATGATGAGATGGAAGTATTGGTGCATTATGATAATGCTTCTAAAAAgcaTGATGAATGGATAAATATCAGTAGTCCTAGGCTGCGACCATTCAGTAACAGTCCATCACAGTCAATAAGCCCTGTGACTAATGCAGAAACTGTAAAAGGCGAAACTAGCATagtaaaagaagaaattaagCAAGAAGACAAACCTAAATTAAAGTTTGTAGTTGGAGAAAGGTGTTTGGCACGATGGAAAGATAATCGAAGATTTATGGCTACTGTAAATAAAGATTTAGGCAATGGCTCTTATGAAATTATATTTGATGATGGCTTCCATTGGAAATGTACCACATGCAGGCTGTATAAAGTAAAACAATCTTCAGAAAGAAATTCTGACCTTTTAACAGTTGATACATCCTCACCATCATCATCTTCCGCTTATCCTTCTCCTATTCCTTGTGGGGCTGGTCCTAGTAGTACTGTTGTAGGGTTAAATGATCCACAATTACCTATTTTCCACACTCACCTCTTTGACCCAACCCGTGATTATTTAGGTTCAAAAAGCGAGCGACGCGAGAAGAAACGCAAGTTAAATataaaagagatatttaatattgGTCAAAAGAAGAGAAGAAAGCAAAAACCACAAGAGGATACGAATGACTCCGCGCCTAAAACGGTTAAGCAGAGAAAACCTAGGGTGgtccaaaagaaaataaaagaagaaaatgacATGCAAGTGAAAAcggaaataaaaaatgaagttcctgatGCTGTAGCATCTATTATTGGTACGGTGGCGAAGGAAGAGTTGGTCATTAAGCAGGAAGTAATATTGGATGATGAAACTATAACTTCACTTAATGACCAGACAATACACAATCTTGATAGACTACCTCAAAATGTGGAAAATGATGAACAACTGAATGATTCAGGCAGAAATGATGAATCAGATATATCAGATACTAAAAACAGTATTGATCCAGTGTTGGAAGAGgaaacaaaacttgaaaacttTGAAATGATAGATGACCGAGAGCATGAGGAAGTTATTGATAGGATTAAAGAAGTTATTACCAAATTAGAAGATGGAATAAGTAAGGCAGAAAGAATAGAATCACCAAAGGTGGAAGTTAAAGAAGAGGAAAGCAAAAATGTTAAAGAACAAGAAGTAACCATTACTCCAGAAGAAAATAAAGAGGCGAACGTAATACCCGTTGGGGATTCAGAGAAAATAAAAACCGAACCAAATGAAGGGAAGATTAAAAAAATGTCTAAattgaaaaaaagtaaaaagttgaGATTGATGCAGGAAAAAAAGGTTAAGAAGCAGGTGGAGAAAGTAAAAAGTGAATTAGAAGAGATGAAACGCCAGGTTGAAGAGATGAAGaaacaaatgttattaaaaaCTGAAGTGTTATCTAGTCCTCAGCAGAAGCAAGAAATGCCAGAAAGCTTTTTATTGCCTGGAGAGTGGTGCTGCAGATGGGTGAATGGACAACCAGTGGGAGCTGTGAGTGAAATAGAAGGTGAAGTTAAAGTTGATGCAAACAGTAAGCCAGCTCTACCAAGACGAAGTGTTCAGGTTGAAGACAAACGGCTGCCTGAGGGATGGACAAAGCACATGGTACGACGGAGCTTCGGAAATTCAGCTGGAAAATGGGATGTTGTTTTAGTTAGTCCGGACAATCGACGCTTCCATACGAAAACGGACATGCGAAACTATCTCGAGCAAAATCCCAGTGAAGAACTCAAACAATACGAATATGCATTACTTGACTTCGGAGTTCATCTTAAACTCTCAAGACGTATGGGATGGGTCACGCAGACCGGTACAGAAGAGCCAGTCATTCCGCTCCCAGCCGGATTGATGAGCAGTACATCACCTCTcgtgaaaagaaaaaaattaagccTGAATCGGGTAAAGGGTATTATTAAAACAAAGCAGAAGAAGAGAAGGTTGGGCGTGGGTGGCAAAATTCGAAAAATGCGACATCGTGTTAATGATGTATTACCAGGGCCAAGTAACGTTGCAACAGATTTAGAACCGTTTGCCATGCACGCTGAAACTATTGACGACAATCCAACATTAGAAGATGGATAcgTCTATGTTGGGGCATTAAAAGTtcaaattattgaaaatttattGCGCTGTCCGGCTGACGGTTGTTTAAAGAACTTCAGAAATAACACATTGTTAAAGATGCACATAAAACATTATCATAGGGAACTTAGGAAGAAGCTTGGTGCTACGCCAAAGGTCCTAGATTTAGCCTATGCTAGAACAAAACCTACGGAAGCAGAAATGAAAAGACAAAGAAACGAAACAGAGAGTAAAATCATAAAGGTAAAAATACCAAGACCaccaaaacgcactgaagaatcAAAAATAGATATGAAAGAGCTTGATTCTGAACTTCAAGTGGATATACCGCTTTCACCTACCAAGAATGTAGATAATATTTCAAAGGCTCAAGATTCCCCAAAATTGCGTAATGCGCTCGCAAACAAACCAGTGAAAAGACCTCGTGTCCTACTTCCTGTGAGAAGACCCGAATCAGAAGTAACTGACAGAAGAGAAGAAGTGGGACTGGACGTAAGAGGGCATACACCAGTTAATATACCAGAAGTTCAAGTACTAGATTTCGAAACTGCCATATCGACTCATACTGTCACAAAACCAGTCGTAGATGGTAAAAGGAAAGGAGAGAAGAGGCGTAAAGGTTTCGCCTCATTTGCAAAAAGATCAATGAGTGAGGATGAAGAGTGGTTGACTATGAACTCCGACGTAGAGACAAGGTCCAGCTTTCCCGGTTCTGCGACACCGGATTCAAAGACAATGGATAATAAATCATATACTAATGCAGCTGCTTCATCAGAGTCCAACGAGGAACAGAAGGAATCGATGTATATGTACACTGAAAATGGCGAGCGCATAAAGATAGTTCAGATGAAACGTGAAGAGATTATAAATTGTCATTGCGGTTTCCGCGAGGAGGATGGCCTGATGGTGCAGTGTGAGCTATGCCTTTGCTGGCAGCATGCACTCTGTCACAACATACAAAAGGAGTCAGAGGTGCCGGACAAGTACACGTGCAGCATCTGCCTTAACCCGCGGCGCGGGCGGCGCTCGAAGAGGTTTCTGCACGACCAGGAGCGGCTGTACGAGGGCGCGCTGGCGGGCGCGCGGCCGAACGATGCGCTGCGCCGCGCGCACGAGCTCGCCGCCAACCTGCTGCGCGCGCGCGACGCGCTGCACGCACTGCGCGTCAAGTACCACGTCGCCACgaaaaagaatcatccaaaatTATATTTGTGGGCAAAAGACTGGGAGAATGCAGAGCTAAACATGACACAGGAGAAGTTGAACTCTGACTATTCAGACCTTAATATCACAATTAATAACATTGGGAAGGAGAACTTGCCATTGAAAACCGATGATATCCAAATGGATGTCCGTACGCCTTTATCTGAAGAAAATGATGAGAGATATAGCAACAGAGAACTTTCCCTTAACTCTCAAACCTTACTAAGTGGGGTGATGTCGAGTCCCGGTGGTGCATCTTTAGACCTACCTATTAGTACTACTGAGTTAGAACGATTGGCGAAATCTGTTCAAGCGGCGGAGGGCGCGGTGGCGGCTCCGCAGCCCGAGGCGGCGATCGAGAACGGCGCGTGCCGCGAGCGCCTGCTGCGCCACATCCAGCGCTGCCAGGCGCTCATCGACGCGCGCCTCGACTCCATAGAGGCGCAGGTCGCTGaGCTTGAATCCCAGGACCCCTCATTCGAAGATGATGAAACTGCGGACTATTTTCCTCGCACCAAGCAGACTATTCAAATGCTGATTCGCGATCTGGATACTATGGAGGAGCTTGGAGTCATTACTTGA
Protein Sequence
MAVKKCCIENCHSCSTRKEDKGVTYHKYPKDLSLRTKWISVTRLKHFDVGTTSYVCSRHFCKSDFQVYKDSKYILKSDAVPSIFTWAIELSNMDSNIANAQSVENIKDLSSSSKESEPENLDAIKKFIEDQEKEIQEQKCEGKHSMLEDQINTDMSQVKEELPECKKQEETLAVATSVMDLILNESETRILSKKEDTECLSAAKRGNSTALTVGSKVEAKDFGEFWYPAQIVEVDYDEMEVLVHYDNASKKHDEWINISSPRLRPFSNSPSQSISPVTNAETVKGETSIVKEEIKQEDKPKLKFVVGERCLARWKDNRRFMATVNKDLGNGSYEIIFDDGFHWKCTTCRLYKVKQSSERNSDLLTVDTSSPSSSSAYPSPIPCGAGPSSTVVGLNDPQLPIFHTHLFDPTRDYLGSKSERREKKRKLNIKEIFNIGQKKRRKQKPQEDTNDSAPKTVKQRKPRVVQKKIKEENDMQVKTEIKNEVPDAVASIIGTVAKEELVIKQEVILDDETITSLNDQTIHNLDRLPQNVENDEQLNDSGRNDESDISDTKNSIDPVLEEETKLENFEMIDDREHEEVIDRIKEVITKLEDGISKAERIESPKVEVKEEESKNVKEQEVTITPEENKEANVIPVGDSEKIKTEPNEGKIKKMSKLKKSKKLRLMQEKKVKKQVEKVKSELEEMKRQVEEMKKQMLLKTEVLSSPQQKQEMPESFLLPGEWCCRWVNGQPVGAVSEIEGEVKVDANSKPALPRRSVQVEDKRLPEGWTKHMVRRSFGNSAGKWDVVLVSPDNRRFHTKTDMRNYLEQNPSEELKQYEYALLDFGVHLKLSRRMGWVTQTGTEEPVIPLPAGLMSSTSPLVKRKKLSLNRVKGIIKTKQKKRRLGVGGKIRKMRHRVNDVLPGPSNVATDLEPFAMHAETIDDNPTLEDGYVYVGALKVQIIENLLRCPADGCLKNFRNNTLLKMHIKHYHRELRKKLGATPKVLDLAYARTKPTEAEMKRQRNETESKIIKVKIPRPPKRTEESKIDMKELDSELQVDIPLSPTKNVDNISKAQDSPKLRNALANKPVKRPRVLLPVRRPESEVTDRREEVGLDVRGHTPVNIPEVQVLDFETAISTHTVTKPVVDGKRKGEKRRKGFASFAKRSMSEDEEWLTMNSDVETRSSFPGSATPDSKTMDNKSYTNAAASSESNEEQKESMYMYTENGERIKIVQMKREEIINCHCGFREEDGLMVQCELCLCWQHALCHNIQKESEVPDKYTCSICLNPRRGRRSKRFLHDQERLYEGALAGARPNDALRRAHELAANLLRARDALHALRVKYHVATKKNHPKLYLWAKDWENAELNMTQEKLNSDYSDLNITINNIGKENLPLKTDDIQMDVRTPLSEENDERYSNRELSLNSQTLLSGVMSSPGGASLDLPISTTELERLAKSVQAAEGAVAAPQPEAAIENGACRERLLRHIQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTIQMLIRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01157807;
90% Identity
iTF_01157807;
80% Identity
iTF_01156562;