Pmac007608.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Papilio machaon
Gene Symbol
MBD-R2
Assembly
GCA_001298355.1
Location
NW:336757-345138[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5.4e-15 1.5e-11 43.4 0.0 5 63 736 793 732 812 0.89

Sequence Information

Coding Sequence
AtggcagttaaaaaatgttgtattgaGAACTGTCCGTCATGCTCCACAAGAAAGGAAGATATCGGGGTAACATATCACAAATACCCCAAAGATGAAAGATTATGTGACACATGGATAACAATTACACGAAACAAACAATTTGATATAGCAACAACATCATATGTATGTTCACGACACTTTCGTAAAAGagattttcaaatttacaaggactgtaaatatgttttaaagtcagATGCAATACCATCCATATTTCCATGGGACAAAACTACATCAAACATGAATTCAAATGAAACGACTTCAGAAGCTGATAATGCAGAAAGTGCATCATCAAGACAAAATGATTTTGAAATGGAAAATCTGGATGCTATTAAGAAATTTATAGAAGACCAAGCTAAAGAGATTGAGGTCCAAAAATGTGATGAAATTGCCGCAGCAACAGATAAAAAGAAAGATATAGAGGATAGAGAGAGATTAAAAGATGAATTAACTGAAAGTGAAATGCAAGAGGAACCATTAACAGTGGCCACAAGTGTAATGGATCTCATACTGAGCCAATCAGAGGCTAggatgttaattaaaaaagaagacAAAGGTTTTGATAAACAATGCGTCGGTCCAGAAGACAAGGGTAATGTTACTTTGTCAGTTGGTTCTAAAGTTGAAGCAAAAGATTTTGAAGAATTTTGGCATCAAGCAGAAATTATTGAAGTTGATTATGATGAAATGGAAGTGTTGGTGCATTATGAAAATGATTCTAAAAaGCATGATGAATGGATAAGTGTTAGCAGTCCTAGACTGAGACCTGTAAACAACACCCCAACCACTACCCCGACCATATCTAGTTCTGAGACTACAAATGTAGAAGTTCcaataataaaagaagaagtcaaagaagaaaaagcaaaattaaaatatgttgttgGTGAAAGATGTTTAGCACGATGGAGGGATAATCGAAGATTTATTGCTACGGTTAATAAAGATTTGGGCAATGGCTCTTATGAAATTGTCTTTGATGATGGATTCCACTGGAAGTGTACAACAAGCAGgatgtttaaattgaaagaCACAGATAGAATTGATCCTTTAAATGTTGATACATCATCATCCTCATCAACTTCCCCATCTCCCATTTCCTTTGGTCCCGGTCCTAGTACTGCAAATACAGGATCTCTGCAAACACCAGTTTTCCATACCCATCTCTTTGATCCGACCCGTGATTATTTAGGTTCAAAAAGTGAACGCCGTGAAAAGAAACGAAAGTTgaacataaaagaaatattcaatatCGGCCAAAAGAAGAGGAAGAAGCAAAAATCACCAAAGGAACCAAATTCTAAAGCACCAAGAGTTATTAAACAGGAAAAACCTGAGCctgtacgaaaaaaaattaaactagaaAATGATGTTGGCATGAAAAATGACATACCAgatgcTCTGGCATCTATAATTGGTACAGTCGCCAAACCAGAGGTtgatattaaacataaaacagaAGTTGAATCTCCAAAAGTTGAGTTGGACAATAAAGAAGATGATTCTATAAATATTCCACAAAATGTAGAAAATGTTCAACATACAAATATCTCAGATGTTAAGGAAGGAATAGAGGTGGCTGAAACTAGGAACAGTCTTGATCCAgtaTTAGAAGAGGAAACAAAACTTGAAAATTTTGAAGTAGGGGATGACAAGACACACGAAGAAGTAATTGATAGGATTAAAGAAGCCATTATTAAATTGGAGGATGGTATGAACAAAACAGAAAAGGTAGATTCACCTAAAGAGGAAATACCAGAAGAAGAAGACGAAGATGAAATTAAAGATGAAATTGAAGCCATTCCAGTTGAATTGACAGAAGAAAAACTACCATTACCTGAACAATCAGCAATGACTGATAATGAAAGTAAAGGTCAGACTAAGAAAAGTGTGTCACATTTGAAAAGGAATAAGAAATTAAGGTTGTTACAGGCGAAAGCAAAGAAGAAAATGGAAAAAGTAGAATGTGAATTAGCAGAGATGAAACGGCAGGTCGAAGAGATGAGGAAACAGATTGTGAGAAAGCAAGAGATGCCAGAGAGTTTCCTGTTGCCTGGCGAATGGTGTTGCAGATGGGTCAATGGACAGCCAGTGGGCTCCGTCAGTGAAATagaaagtgaaataaaagtaGATCCAAACAGCAAACCACCTTTACCAAGACGAAGTGTTCAGGTGGAAGATAAACGTTTGCCTGCGGGATGGACGAAGCATATGGTACGACGAAGTTTCGGCAATTCAGCTGGGAAGTGGGATGTTGTTCTGGTTAGCCCTGAAAACCGTCGCTTTCATACTAAAACTGATATGCGAATGTACATCGAGAAAGAAGCTACCGTAGATCTCAGACCTTACGAACATGCTTTACTGGATTTCGGTATCCATTTGAAGCTAGCGAGGCGTATGGGTTGGGTCATCCACACAGGTACCGAAGAGCCGGTTACACCCTTACCAGCCGGTATGATAAGCAGCACATCCCCACTTGTCAAGAGGAAAAAGCTTAGTCTCAACAGAGTTAAGGGTATAGTCAAATCaaaggaaaagaaaagaaagtgGAATGGAGACACTAAGATACGTCGTATGCATAAACATGCGAATGCTGGTTTACCTGGAACAAGCAATGATATTTTTGATTCTACTAGTAATGTTGAAACACCTAATGAAAATGCCACTTTAGAAGATGGATAcgTTTTTGTTGGATCTTTAAAAGTACAAGTCATCGAAAACTTATTACGGTGTCCAGCTGATGGTTGTTTTAAGAACTTTAGAAATAATACACTATTAAAAATGCACATCAAACATTACCACCGAGAACTAAGGAAACTGCTCGGCTCTACGCCTAAAGTTCTAGACTTAGCTTACGCTAGAACTAGACCAACTAAATTACAAATGactaaattgaaaaagaaaagagaaaacaaagtgattaaagtaaaaatacctAAACCTATGAAGCGTACCGAAgacaaaatagatataaatgaACTGAACGCTGAACTACAAGTGGATATACCGATATCTTCACCACCAGATTTAGGAACTCTACCAAAGGAACAAGATTCACCCAAACTGCGTAACGCACTAGCTAATAAACCAGTTAAAAGACCTAAAGTCTTACTTCCAGTTAGAAGACTAGATTCAGATACGAATGAAAACTTTGGGGAACTAGGATTAGAAGCGAGAGGTAGTACGCCAGTTAGTATACCGGAGGTATTCGATTTTGAAAGGGGTATATCGACTCATACAGTGACAAAACCGATACCAGatttaaagaagaaagatAAGAAGCGAAGAGAATTCGCCACTTTCCCTAATAACCAAAGCGAGGATGATGATTGGTTTTCAATGAATTCTGATGTAGAAACGAGGTCCAGTTTCCCAGGCTCCGGTACTCCGGATTCGAAGACGatggaaaataaaacttcagtCAATGCTGCGCCGTCTTCTGAGTCTAATGAAGATCAGAAGGAAACAATGTACACGTACACGGAGACGGGCGAGCGCGTTAAGATAGTTCAGATGAAGCGCGAGGAGATTATAAATTGTCACTGTGGGTACCGCGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGCCTGTGCTGGCAGCACGCGCTCTGCCACAACATACAGAGAGAGTCAGAGGTTCCAGAGAAGTACACGTGCAGCATCTGCCTGAACCCGAAGCGCGGGCGACGGTCGAAGCGCTTCGTGCACGATCAGGACCGGATGTACGAGGGCGTGCTGGCTGGTGGGGCTAAGCCTGCGGAGCCGCTGCGGCGCGCGCACGAGCTCGCCGGCAACCTGCTGCGCGTGCAGGACGCGCTGCACGCGCTCAGGGTTAAATACTATGTCGCCACGAAGAAAGATCATCCCAAGTTGTATTTATGGGCGAAAGACTGGGAGAATACGGAATTGACTATGACACAGGAGAAATTGAACTCGGACTATTCGGATCTTAATATAATGATACATAAtattgggaaagagaacttGCCCTTAAAAACGGATGACGTCAGAGATATAGCAATGGACGTGACGTCAGAGGAGGGCGAGAGGTTCACTCAGAGAGATATACCTCTCGGCCCTCAGACACTACTTAGCGGGTTACTCTCCAGTCCTGGCGGCACTTCCTTGGAACTGCCTATTAGTACTTCAGAGTTGGAGAGATTGGCTAAATGTGTTCAAGAACAAGGGCCAGCAGTCCGCGTGCCACAGCCCGAGGCTGCGATAGAGAACAGCGCGTGTCGCGAGCGCCTGCTGCGTCACATTCAGCGCTGTCAGGCACTCCTAGACTCACGGCTGGACTCCATTGAGGCACAGGTCGCGGaATTGGAATCCCAAGACCCGTTATTCGAGGATGATGAAACGGCGGAGTTCTTCCCACGCACCAAACAGACGATACAGATGCTGCTGCGTGATCTTGACACTATGGAGGAATTGGGTGTCATCACTTAA
Protein Sequence
MAVKKCCIENCPSCSTRKEDIGVTYHKYPKDERLCDTWITITRNKQFDIATTSYVCSRHFRKRDFQIYKDCKYVLKSDAIPSIFPWDKTTSNMNSNETTSEADNAESASSRQNDFEMENLDAIKKFIEDQAKEIEVQKCDEIAAATDKKKDIEDRERLKDELTESEMQEEPLTVATSVMDLILSQSEARMLIKKEDKGFDKQCVGPEDKGNVTLSVGSKVEAKDFEEFWHQAEIIEVDYDEMEVLVHYENDSKKHDEWISVSSPRLRPVNNTPTTTPTISSSETTNVEVPIIKEEVKEEKAKLKYVVGERCLARWRDNRRFIATVNKDLGNGSYEIVFDDGFHWKCTTSRMFKLKDTDRIDPLNVDTSSSSSTSPSPISFGPGPSTANTGSLQTPVFHTHLFDPTRDYLGSKSERREKKRKLNIKEIFNIGQKKRKKQKSPKEPNSKAPRVIKQEKPEPVRKKIKLENDVGMKNDIPDALASIIGTVAKPEVDIKHKTEVESPKVELDNKEDDSINIPQNVENVQHTNISDVKEGIEVAETRNSLDPVLEEETKLENFEVGDDKTHEEVIDRIKEAIIKLEDGMNKTEKVDSPKEEIPEEEDEDEIKDEIEAIPVELTEEKLPLPEQSAMTDNESKGQTKKSVSHLKRNKKLRLLQAKAKKKMEKVECELAEMKRQVEEMRKQIVRKQEMPESFLLPGEWCCRWVNGQPVGSVSEIESEIKVDPNSKPPLPRRSVQVEDKRLPAGWTKHMVRRSFGNSAGKWDVVLVSPENRRFHTKTDMRMYIEKEATVDLRPYEHALLDFGIHLKLARRMGWVIHTGTEEPVTPLPAGMISSTSPLVKRKKLSLNRVKGIVKSKEKKRKWNGDTKIRRMHKHANAGLPGTSNDIFDSTSNVETPNENATLEDGYVFVGSLKVQVIENLLRCPADGCFKNFRNNTLLKMHIKHYHRELRKLLGSTPKVLDLAYARTRPTKLQMTKLKKKRENKVIKVKIPKPMKRTEDKIDINELNAELQVDIPISSPPDLGTLPKEQDSPKLRNALANKPVKRPKVLLPVRRLDSDTNENFGELGLEARGSTPVSIPEVFDFERGISTHTVTKPIPDLKKKDKKRREFATFPNNQSEDDDWFSMNSDVETRSSFPGSGTPDSKTMENKTSVNAAPSSESNEDQKETMYTYTETGERVKIVQMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIQRESEVPEKYTCSICLNPKRGRRSKRFVHDQDRMYEGVLAGGAKPAEPLRRAHELAGNLLRVQDALHALRVKYYVATKKDHPKLYLWAKDWENTELTMTQEKLNSDYSDLNIMIHNIGKENLPLKTDDVRDIAMDVTSEEGERFTQRDIPLGPQTLLSGLLSSPGGTSLELPISTSELERLAKCVQEQGPAVRVPQPEAAIENSACRERLLRHIQRCQALLDSRLDSIEAQVAELESQDPLFEDDETAEFFPRTKQTIQMLLRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01144600; iTF_01142409; iTF_01142454; iTF_01143844; iTF_01143890; iTF_01138961; iTF_01149617; iTF_01149661; iTF_01148886; iTF_01148830; iTF_01147398; iTF_01147439; iTF_01140216; iTF_01140260; iTF_01148155; iTF_01148111; iTF_01140988; iTF_01140938;
90% Identity
iTF_01149617;
80% Identity
iTF_01144600;