Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 8.8e-08 0.00027 20.3 0.0 39 72 5 33 5 37 0.91

2 2 0.00062 1.9 7.9 0.1 29 74 55 108 40 111 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	8.8e-08	0.00027	20.3	0.0	39	72	5	33	5	37	0.91
2	2	0.00062	1.9	7.9	0.1	29	74	55	108	40	111	0.86

Coding Sequence: ATGTTTATTATTACAGGTAAAAAGTTTCGCAGTAAACCAGAGCTAGTTCGATATCTCGGTGATAGTATGGACCTGTCATGTTTCGACTTTCAACAGGGCCAAATAAACACAATGCTCCTGTGCAAGACCAAGAAAGCTCGAGCCCAGTTTGACTACAGGGGAGTTCGATCCGACTCATCTCTTGTGCCACCTATTCGTCAGACAGCATCCATTTTTAAACAGCCAGTAACCGTTTATAAAACTCAGGAAAGTAAAGTGAAAACAGATTTGAAGCAAGGTACACAAGAAAAGCCAAAACAACTGTTTTGGGAAAAACGTTTAGAGAACTTGACTGCGTGTGATGCAAATGGGGTCATAGGAACTACAACATTGCCAAAATATATCAAACCTTTAGGTCCATTTACATCTGATGCAACAACTATACAGTCTCTGGCTACCGCTCTTCATGTTTCATCACAGCCAATTACAGGACAAACTGGATTAAAGCAAACAATAATGGAGAATCCAGGCGTTTTTTTAAACCCTGAGCAGCCTCTCATTGCTTCCGTTACTATAACTAAAGATGACGTGAGACGTCAAGAGGAGCGAGTCAACCGCGCTCGACAGAGACTCCGGGCAGCTCTAGCGGCGGCATAG
Protein Sequence: MFIITGKKFRSKPELVRYLGDSMDLSCFDFQQGQINTMLLCKTKKARAQFDYRGVRSDSSLVPPIRQTASIFKQPVTVYKTQESKVKTDLKQGTQEKPKQLFWEKRLENLTACDANGVIGTTTLPKYIKPLGPFTSDATTIQSLATALHVSSQPITGQTGLKQTIMENPGVFLNPEQPLIASVTITKDDVRRQEERVNRARQRLRAALAAA

Sequence clustering based on sequence similarity using MMseqs2