Basic Information

Gene Symbol
-
Assembly
GCA_949127965.1
Location
OX421871.1:3207565-3231407[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.1e-16 1.8e-12 47.4 0.0 7 70 205 266 201 271 0.87

Sequence Information

Coding Sequence
ATGTCCGAGGAAATGGCGGTTAGTGATAACCCAACTGGGGAAGAAAACGTAGTCAATGGAGGAGAGGCGTCTGCTTCGAGTGCCGAGGACGTGGTGCTAGCGGCGCCCGAGCCGCTGAGCCAGCCCGCGGACGAGGAGCCAGAGGATGTCAAACCCATTATAGAAGaTATTAAACCGAGTTTAGACGATGAACTTGATGAACTTGATGATATCACAATCAAAGAAGAGCCGATTGAAGATCGTAGTGACAAGCGAGGCACCAAGCGCAGGGCTTCAGCTGCCTTTAGTAACGCTGCTGGTGAAGACTTCAAGGGTTTCGCGAAGACCGAACTTGATGACTCTACACTGGACTATAAGCGAGTCCTGGAAAACCTAGAGGCGGAGGTGACGGAAGCTAGCAAGGATGTGGTGCCTCTGCAAACCGTAATGGGAACTCCTTTGGCACCTGCACGGGCTAGCAAGCGAGCCAGACAGGACACGGATGGTTCCCGACCATCATCAGCGCTGTCTTCAAGATCTGATGGCGAGGGTGCCGTCTCTTCCACTGAGGTGAGCAGCTCGTCGCCGGCGGTGCGCGGTCGGCGCGCTACCACCGAGATGTCCTCGCCGCTGCTGCGCGTGCCGCTGGAGCGCGGCTGGAAGCGCGAGCTCGTGTTCCGCGCCGCGCTCGACCAGCACTCGCGGCGGAACGCCGACATCTACTACTACACGCCGCAGGGCAAGAAGCTGAGGTCCACCAGAGAGGTAGCAGAACACCTTTCTGGCACCGGACTGACCATAGAGAACTTCTCCTTCTTCAAAGAACCACTGGGTGTGGATGATCCAGAAAAAGAAATTATTCGTGATGCGAAGATGATGCGGCGCGTGGAGTCGCCAGTGGCGCAGGCGCCGCCCCCGACGGAGGGCAAGCGCACGCCCAAACCCAAGCAGCCAAAGGGCGCGAGCCCCGAGCCGCCCAAACCAGCGCCGGTCAAAATCAAGGTGAAGTCGATCGGTTCCCGGCTCAGCAACAACTCGCCGGCGACTCCGCCGACGAAGCCAAAGAAGCCGGCGGCCGCCGACAACAACAACAGCGCTGCGTGGAAGAAGAACAGAacggcgcccgccgccgcgcccgctcccgcCCCCGCCTCTGCCCCCGCGCCAGTCTCCGCGCCCgcacccgcgcccgcgcccgcccccgctccgcctgcgccgccgccgctgcacaGCCGCCCGCCCACCACGCCGGAGAGCGTCAAGGAGGTTGATCAGGATGAGACGCCGCCGCGGCAGCTGGTGCAGCCGTGCTCCATGacgtgcgggcgcggcgtgccGTCGCTGGCCTGCGCCGCCTGCCTCTGCCTCTACCACCCCGCCTGCGCCGGCCACACCGCCGCTCCCGCCACCACGTTCTTCTGCAAGaactGTCGCGCGTGCTCGACGCCGCCGCCGGAGCCGCCGCCGCTGACGCACAAGTCGggcgctgcgccgcgccgcccgccccccgccgcgcccgtgcccgcccccgcgccgcgcccgcgcaccgacCAGCGCGTGCTGCTCAGGATGAAGgtggcgggcggcgggccggaCGGCGAGCGCGTGTGGGCGgtggctgcgccggcgccggcgcgcgcgctgctgctgcggcccgcgctgccgcagTCGCTCGCCGTGCTCAACGGCCGGCGGTTCATCGTCGTGCCGCGCGCGCTCGTGCAGCCCGACCcTGATAGCAAGGGCGTGTTGCGAGGGCGCTTGGCGAACGGCGCGGCGTCCCCGCCGGCGCTCCCGGCCGCCtcgccgcggcgccgcggccgccccAAGCCCGACGACACGGACCACTTCACCGCCTTCTACAACAAGGCGAGGGAGCGGAACTACAATGTTGCGGTGCAGATATTCCAGTACCTGGGCATGCGCGAGCTGGCGCAGTGCGCGCGCGTGTGCCGGCTGTGGCGGCAGCTGGCCGCCGAGCCCGCGCTCTGGCGGCACGTGCGCATGAAGAACTCTCACGTGAGCGACTGGGgcgggctggcggcggcgctgcgGCGGCACGCCACGCGGCGGCTGGACCTGCGCAAGATGCTGCTGCCGCAGAACGACGCCGCCTTCTGGGACCAGTTCGCCGAACACGTGCACCAGCTCGCTGATCTCGAGAGGATAGAGATGTGCCGCTGCCCGGCGAGCGCCGTGGAGGCGGTGTGCCGCGGCGTGGCGGGGCTGCGCTCGCTGTCGGCGCTCGCCATCCGCTCCGCGCTGCTGGACCCCGCGCCGCTCGGCGCGCTGCCGCTGCTGCACGAGCTGCGCCTCAAGAGCATGGCCGGGCTCTCGCTCACGAGGGACCTGCAGCCGCTGGCGGCGCTGACGAGTCTCACGCATCTTTCGCTCACCTCCATCAAGGAATTGGGCTGGTGCGCGTGCGACGTGGTGGGGCAGCTGCCGCAGCTGGAGTCGCTGGAGCTGGGCGAGTGCAGCTTCCGCGCGGAGTTCGCGGCCGTGCTGGCGCGCCTcacgcgcctgcgccgcctgcGCCTGGAGCGCGGCACCGCGCagtgcgccgcgcccgcgctgctgcgcgcgctCGCCACGCTGCCGCTGCTGCACAGCCTCGAGCTCGTCAACTTCGACGTCAAGGTCGGCTTCGACGACGCCCTGGCGGAGTGCAAAAACATTCAGAGGCTGCTCATTATACCGACATACGTGTCGCAGTCTGCCACGACAAATCAACAGGTGCTAAGCGGCGTGCTCCGGCTGAAGGAGACGCTGACGCACCTGATGTGGGGCGTGACGATCGAGCTGCTGCGCGTGACGGAGCTGTTCATCGACCAGTGCGAGCAGGgcgccgggcggcggcgcgacGTGGGCGAGTGCATCCCCGTGCTGAAGCCCGTGCCCGGCTGCCGCCTGCCCGCGCCCGAGCCGCCGCCCAAGGCCCCCCACCACCACACGCCGCCGCAGGTGGAGATTCTCCCGCTGCCGACGCTCCAGCGGCTGCTGTCAGCGCAGTTGCCCACGACCAAGCTGAAGCTCCTCCGCATCCCGTTCCACGCGACCTGGCGGCAGTCGCTCGCGGACTTCCAGTAG
Protein Sequence
MSEEMAVSDNPTGEENVVNGGEASASSAEDVVLAAPEPLSQPADEEPEDVKPIIEDIKPSLDDELDELDDITIKEEPIEDRSDKRGTKRRASAAFSNAAGEDFKGFAKTELDDSTLDYKRVLENLEAEVTEASKDVVPLQTVMGTPLAPARASKRARQDTDGSRPSSALSSRSDGEGAVSSTEVSSSSPAVRGRRATTEMSSPLLRVPLERGWKRELVFRAALDQHSRRNADIYYYTPQGKKLRSTREVAEHLSGTGLTIENFSFFKEPLGVDDPEKEIIRDAKMMRRVESPVAQAPPPTEGKRTPKPKQPKGASPEPPKPAPVKIKVKSIGSRLSNNSPATPPTKPKKPAAADNNNSAAWKKNRTAPAAAPAPAPASAPAPVSAPAPAPAPAPAPPAPPPLHSRPPTTPESVKEVDQDETPPRQLVQPCSMTCGRGVPSLACAACLCLYHPACAGHTAAPATTFFCKNCRACSTPPPEPPPLTHKSGAAPRRPPPAAPVPAPAPRPRTDQRVLLRMKVAGGGPDGERVWAVAAPAPARALLLRPALPQSLAVLNGRRFIVVPRALVQPDPDSKGVLRGRLANGAASPPALPAASPRRRGRPKPDDTDHFTAFYNKARERNYNVAVQIFQYLGMRELAQCARVCRLWRQLAAEPALWRHVRMKNSHVSDWGGLAAALRRHATRRLDLRKMLLPQNDAAFWDQFAEHVHQLADLERIEMCRCPASAVEAVCRGVAGLRSLSALAIRSALLDPAPLGALPLLHELRLKSMAGLSLTRDLQPLAALTSLTHLSLTSIKELGWCACDVVGQLPQLESLELGECSFRAEFAAVLARLTRLRRLRLERGTAQCAAPALLRALATLPLLHSLELVNFDVKVGFDDALAECKNIQRLLIIPTYVSQSATTNQQVLSGVLRLKETLTHLMWGVTIELLRVTELFIDQCEQGAGRRRDVGECIPVLKPVPGCRLPAPEPPPKAPHHHTPPQVEILPLPTLQRLLSAQLPTTKLKLLRIPFHATWRQSLADFQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
iTF_00155318; iTF_01135774;
80% Identity
-