Basic Information

Gene Symbol
Zfa
Assembly
GCA_947562075.1
Location
OX387274.1:14144799-14153735[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 23 0.01 0.95 10.8 1.6 3 23 731 752 730 752 0.96
2 23 0.22 21 6.6 0.3 1 22 1135 1156 1135 1156 0.95
3 23 9.9 9.4e+02 1.4 0.3 1 20 1198 1217 1198 1221 0.80
4 23 0.099 9.4 7.7 4.8 2 22 1231 1251 1230 1251 0.93
5 23 5.2 4.9e+02 2.3 0.1 3 23 1260 1281 1258 1281 0.89
6 23 0.019 1.8 10.0 0.2 3 23 1300 1321 1298 1321 0.96
7 23 0.0019 0.18 13.1 1.7 1 23 1327 1350 1327 1350 0.95
8 23 0.13 13 7.3 0.0 1 23 1376 1399 1376 1399 0.90
9 23 0.02 1.9 9.9 3.4 1 23 1404 1426 1404 1426 0.97
10 23 0.0091 0.86 11.0 0.2 1 23 1432 1455 1432 1455 0.95
11 23 0.0042 0.4 12.0 0.8 1 23 1468 1490 1468 1490 0.97
12 23 0.00019 0.018 16.3 1.8 1 23 1540 1563 1540 1563 0.97
13 23 0.00036 0.034 15.4 0.8 1 23 1621 1644 1621 1644 0.96
14 23 0.0025 0.24 12.7 2.1 2 23 1671 1693 1670 1693 0.95
15 23 0.042 4 8.9 0.1 2 23 1699 1721 1698 1721 0.94
16 23 0.01 0.99 10.8 0.2 1 21 1765 1785 1765 1786 0.95
17 23 0.00044 0.042 15.1 1.0 1 23 1796 1818 1796 1818 0.93
18 23 0.00012 0.011 16.9 0.3 2 23 1911 1933 1911 1933 0.93
19 23 4.2e-07 4e-05 24.6 1.4 3 23 1940 1960 1939 1960 0.98
20 23 0.023 2.2 9.7 0.3 1 23 1978 2000 1978 2001 0.95
21 23 0.13 12 7.3 0.0 1 23 2024 2046 2024 2046 0.97
22 23 0.029 2.8 9.4 0.6 1 23 2052 2075 2052 2075 0.95
23 23 0.00027 0.026 15.8 0.4 1 23 2083 2106 2083 2106 0.96

Sequence Information

Coding Sequence
ATGAATGTGAACTATGATCGTGTTTGTAGACTGTGCTTGTCATCTCGAGGCGAATTACTGCCGATTTTTCCTACCACCAGTTCGGATGACTCGGAACCTCCCGTCCTCGCTTTGAAAATCAAGGATTGTGTGTCCGTACAGATAAACGAAAATGACGACCTGCCCACCAATGTCTGCAGGAAATGCATGGACAATGTCAATAACTGGCATGTTTTTAAAAATGTATGTGAAAGGACACAAAACAAACTACAGTCTCTGAAAGATGGCAGCCAACTAGAAGAGGTGAAAATAAAAAGTGAACCACTGTCTGATGAGGCTTATGATGATGGAGTGGTCATTGATGGCTCATATCCTGTCATTGAGAATGCTGGCTTTTCAAACAAAGTACAACCTGAAGGTCCCCCAATCTTGGCTTCATTGGGGCTCACACCAAGAAGTGATAAGAAATGTGTGGATCCGCGAATGGATTGGCATCGGGTCCATGCTATTTTGGACATGGTTCAAGACAATGAGGTGATTGACTCTCTGCAGACAAAGGAAGAGTGTGATGTTTTACAGCAATCTGATCATGACTCTGACTCAGAAGCTGATCTCAAACCTGAAATTGATGATGATTATGTCGATTGCAAAAGCGGTTACATTTGCAAAAATAAAAAAATTATATCAAAAGCTCCAAAACTATCAACTTCTGTAAACAGTGCCAGAATAAAAGAAGCTTTCAAACTCAGGAAACGTAAATTAGAAGTCCATAAACATTGTTCTCGACCTAAAAATGCGTGGCAATTGTTATTCACCGATGACCTACTAGAATTGATTGTTGCATCAACTAATGACAATATTGTGACAAATGGGAAAAGTTTCTCAGAGTCAACTAGTGTCAGCGAAATTAAAGCGCTTATCGGTATTCTGTATCTGCACGGCATAATGCGACCGACGCATCAGAAATGTGCTGACCTTTGGAACAGCGAATGTGGCGTTCCTTGCGTCAGAAATGTCATGAAATACGAAAGGTTCAAATTCTTGCTTCAAAACATGAGCTTCGATAAAGAGGACGACAACAGCATTATTCAGTTCGACATAATGAAGCGTATGCGCAAAGTATTCGAAATCTTCGCCATGAATTGCAGAACATCTCATGAGATCGAGAATGTCGCGGTTATTGATGAGATCATTGTGCCAGTTTACGGACCTTGCCCATTTCGATACGATATTGATAAGAAGCCGCTGAAGCGGGGCATAAAAATGGTATTGCTAGTTGATTCATCCACATTCTACATGAGCAATTTAGATGTCATTACTGATCCTTATTTTGGTGCCGAAGAGATAACGAAAAAGTTGGTTCAGCATTTAGCTGGAACTGGCAGATCTATTGTTATGGACAGTTGGTTTACATCTTCCTCATTGATGGATAGCCTTAAAAATGAGTACCAGTTGTATTCCATCGCAGCCCTGCACCCAAATAGTGATATGATTCCACCTCTATTCCTATCACAATACAGGAAAACTCGAACATTCATGTCTGGATTTATTGATGATGAAGTATCATTGACATCTTATGTCAATGCTGAGGGAAAATCAGTTAATGTGTTGACTAATGAGCCTAGATATTATAGGAAAGGTCATATAAATCACACTACAGTTGTATCGGTGTATAAGAAGACGCAATCTGCTGTAGAAGTTGTTGATGTTCTCATGAATTACTACACCACAATGCAACACACGAATGATTGGACATTGACTTTATTCTTCACGTTGCTGAATATTGCCTCTGTGAATGCTCAAGTGCTGTGGTGCTCTCAGAACTCGAATTTTACACAGCGTCGCTTATTTATCAAGGATTTAGCTTTAGGCTTACTTGAACCAGAGGAAGAAAGAATTTTAATATCTCCAATAAAAGATTTAGATGAGAAGAAAAACAAATTCTCTCTGGAACGCAATAATTCGCAACCATATTATAAGAATAGAAGAAGGTGCAAAATATGTGTGAGGACAACGAAACGCGATAGGAGAACAAGACAGTTCTGTGGTGCCGAGAGCGAAAATAATGAAGAAGACGAGGAAGAAATTAATGAGCCCGCACAAAATTACCCGAAAATGCCAAACATGCCTGAGGTATCCATTACGGTCATGAGGACTACCGGTGAAACCCTTCATGCTCGTCAAGGTATTCACCAACTCGCCTCAAAACTGTGCCTCGTCTGCGGTCGCTCCTACAGGTACTCTCACAATGCACGCAGACATGAACTTACTTCTCACGGCTTCGACAGATATACCAACAAAATTACTCCTAAAAAAACCCTGAATCATCTACAACCTAAACTCAGACCGAACCCATTCAACCCCAAGGCAAGGATGATGCCGAATCCTATTAGTCATAAGATGCAGTTCTTGAACAAGAATATGCCAACAAAAATAATGCCCATGAATAAAGTAATAACGCCGCAGAGACCCATTCCAATAAAGACAACATCAAAGACACAAAATAATTTGCCTTATCCTCTACGCATTAAAGCACTCAAAGATTTACAAATTAAAAAAAAGGAGCCTCAGATTCTCAAGACTTTGTTAACTTCTAAACCTGAAGTTCTGGTTTCAGAACCAGAAATCCTAAATTCTGGGCCTGAAAGTCCAGAAACATTGATATCTGAGCCTGAAATTGCGTCTTTTCAAGTCGAAGCTATCCTTACGGAACCCGACGCCGACGCGTACGATGATCCTCAGCAAGGTGATGAAGAAGTTGATGAAGAAATGCAAAACAATCAAAGTCAAAACTATGACACAGTCGATATGGACTCTGACAATGAAATAGAAATTGCTCGTCAACAAAGCATTGAACAAGAAGGTGAAGAAAATGCTGAAGGGGAAGAGAATATCGACCATGATGACGATAATAATGAAGCCGGTCAGAGCGACAATGAGAAAGATGTTATTGACGATACAGCTGAAGGTCAAGAGAACATGGAAGAAGAAGATAGTGTTGATATTAAACCTGGAGATCATATAAAAGACGACGAGGACCAAGAGGACGGAGAACATGAAGAAGTAGAGATGAATCATAATGAGGACGATGAAGACGATGATGAGCTTCCAATAACATTAGCACCAGTCGTTGAGATAAATGAGGGATTGCAATCCAACTCGTTTAACAGCCAAGCTAATGAAGAAGACGAGGAACTTGACGAAACTGTCGATCCTAATGAAACCATCGACGATGCAGAGCAGGTTAAAGAACTTGACCCTGACAAAACATATGTTACAAAAACCCAAAGAGACTTCATTCAAAAATATCGCGATATCATTCAGCAAATCAACACGAAGCGATGTTTATGTTGCGATCGCGAACATCCGCGCCGAAAAGCTGTCATACAACACTTGCAGAAAAACGGACACAAAGTGCCAAAACACACTTGTTACAATTGTGTCATCACGTTTGGACATATTGGCGCACTACTCAGTCATATGAGGTCCAACTCTTGCACAAATTTGTGGAAGATTATTTACAATGAAAATGGCATTACCGACGACTTAGTTCTCGAAGATGAGCCGAAAGAGGTCAAGGTTGCTTACAAAGATATTTTCAATGCTAGGTCATACGCTTGCAAGCTCTGCCCAGCCAAATTCCAACTGAAACAGTTTATAATGAAGCATGTAGCGGATACGCATGAAGATGGGCAGTCTAGGGTACCGCTCTGTTGTGTCCACTGCCGTTCCAGGTTCAAAGAGAAGAGTTTACTCAAGAAACACATTCGTAAAGGCGATTGTACCGTTTATATTGCTTGTGATCTGTGCTCGGACACATTTAGAAACATGCAGGACTTTAACGACCATGCTTTAGCCATCCACGCTGGCAGTTTCGATGATAATCAGAGCAAATGTGTTGATGGTCGGCCAACAGACTGTCCACTGTGCGGAAAGAAAAACAGTAGCTATCCGAATTTAGTGAAACATTTGAAGATTATACATGCTGAGGAGAAACCTCACTACTGTCAGCATTGCGACGCTAAATACGAACAAGCTGCTGATCTGAACAAACACATTTACATGGAGCATTCCGATAGAACTTTAGGCATGCCGCCCGCGGAGCCGGATATGTCCATAGTGAAGGAAGAAGCAGAGGAGTATCATTATTCCTGTACGGAATGTAATGCTATATTCGAAACTGTTGATGCGTGGACTGATCACCAAGTTGCCGAACATAACCAAGTGGCCCACCACTGCGACCAGTGTGAGAAGAAGTTCCTGCGTCCATCAGAGCTGGCCGAGCACAAGAACACGCACTTGAGGGTTAAGTTCTATCCTTGCAGTGTATGTCCCAACTCTTATAGTACTCCACAGAAGCTGTCTGAGCATGTGCAACAGTCACATCCAGGAATTGGTGCAGTCGCGGCAGCTGAGTCGGAGTTCTTCTGTGACATCTGCATCAGGGCATTCAAAAGTCGCCAAGCGTACTCGAATCATATGCGTATTCACGCTAAAGTACCTACTACTAACAGGAAACCGGCTGCAATTAAAGAAGGCTTTGCGCCTCAAATTATCGGCAAACCCATCAAACAATACCCAATGGTTCAACCTGGGTTTGTATCATTTAAACCTAATTACAACATCCCTAACGCTCCATATTCTTGTGACATTTGTGGTAAAGGTTTTATGCACAAGAAGAATATATGGAAACACAAGAAAGTGTTGCATGCCGATATTTTAGTCGATAGACATGATAGTGAGGAGAACACTATGCAAGCATCCACTGAAGAAGAGGAATTTAACCCTGATGAGAATGGTGCCATCCTCTCTACGCCACAATTTAATAGTTTCAACTTTGCGAACTTGAACAATGCTCAACAAACGCCTCCAGAAATGCCTTATGAATGTGAAATATGTAGCAAACGGTTCCCGCTTAGGACCAGTTTGTGGAAACACAAGCGTGCTAAACACGGAATTGTGAACCCTAGCACTAGTGGCAGCAACGAGGTATCCCAGCCATCCGCCAGCGGGGAAGGCAGTAGTAGATCTAGCTGCACTATATGTAGAATCACATTTTCTGATAAGAAATCATATTATCGCCATCGAAAGAATGTCCATAAATCTACCGTTCAAATGTGCAAAATATGTGGCAAACCGTTAAGTTCGACTTTAGAACTATACGAGCACTTGAAAGCCGCTCATGCTAGGGAGTTACTGGGTTACAACGCCAACCAAGGCTCCAGTAAATCACAAGATGTGTCTCAAGACATGGAACCTGAATATGAAAATGATCAGGAATCTGTCGACCCTAGCGTCGATTACCAAGCGCGCTACCCGTGTGATACTTGTGGCAAACAATTCGTTGGTCTGCTAGCGTTGCAGAACCACCAGTGCATCAACCAGGTGCCATCACAACCACAGACGTTTGACTGCGAGATTTGTCACAAAAGCTACACTTCAATATCTGCATTAAAAAGCCATCGTGGATGGCATTTACGTTCGCCCGATGGGAAGGCAGCGGCCAATAACTCTGGCCTTTGGATGCCTCAGCACAAAGTAACTAGCAAGATAAGTAAACACGAAGTCATCGACCCGTCTCAACTTGCGAAGGTCACACATACTCCCACTCCGCCTCCTGTCACTGCCTCCGCAGCGAAACGAAGATTGCCACCAGAGGTCGAAGTGACAGTAGTAAATCCAAACAAGAAATTGCGCTCAGACGACTCTGTCGACATGGATATGCAAAATTCTGGTTCAATGGAGGATCGGTACTGCACGATATGCGACAAGGAATTTACAAAACGAGCGGCGTATCAGCGCCACATGGACGAAGTGCATCAGCCGAACTCTGTGTTTTGTCCGGTCTGTGATAAGAGTTTTACAAGGAAGTCCACACTGCTCATTCACATGAAGAAACACTACGAGAGTGGTGAGGGCAGTTCCTCTGCTACAGGTCAAGGGGACGATGATTATTCTTGTGATTTGTGTGGCGCTCAGTATGATAATGATCAGGCGTTGAGGGCGCACCGAGCGCGACACCATGGAGAAGACGAAGAGTCTGCAGAAGAGAGTGATGACGGAAATGTCCCTGTAGCTCCTCCCGGCGAATTTACATGCGGGCAATGTGGCGATGGCGTCGCTACTCCTAGGGACCTCATCGCCCACCGCACAATGCACGCTACACCCACCAAATTCTTCTGTAACATATGCAAAGTGTACTTCGCTCGCGCGCTCGACCTCTCGTCACACACTCGAGCGCGACACGCTGATAATGAAAAGGTATTCTTCCCGTGTGCCATGTGCGACAGGTTTTATATGAACAAGAAGAGTTTACAGCGGCACATCGAGATGGCTCACTGA
Protein Sequence
MNVNYDRVCRLCLSSRGELLPIFPTTSSDDSEPPVLALKIKDCVSVQINENDDLPTNVCRKCMDNVNNWHVFKNVCERTQNKLQSLKDGSQLEEVKIKSEPLSDEAYDDGVVIDGSYPVIENAGFSNKVQPEGPPILASLGLTPRSDKKCVDPRMDWHRVHAILDMVQDNEVIDSLQTKEECDVLQQSDHDSDSEADLKPEIDDDYVDCKSGYICKNKKIISKAPKLSTSVNSARIKEAFKLRKRKLEVHKHCSRPKNAWQLLFTDDLLELIVASTNDNIVTNGKSFSESTSVSEIKALIGILYLHGIMRPTHQKCADLWNSECGVPCVRNVMKYERFKFLLQNMSFDKEDDNSIIQFDIMKRMRKVFEIFAMNCRTSHEIENVAVIDEIIVPVYGPCPFRYDIDKKPLKRGIKMVLLVDSSTFYMSNLDVITDPYFGAEEITKKLVQHLAGTGRSIVMDSWFTSSSLMDSLKNEYQLYSIAALHPNSDMIPPLFLSQYRKTRTFMSGFIDDEVSLTSYVNAEGKSVNVLTNEPRYYRKGHINHTTVVSVYKKTQSAVEVVDVLMNYYTTMQHTNDWTLTLFFTLLNIASVNAQVLWCSQNSNFTQRRLFIKDLALGLLEPEEERILISPIKDLDEKKNKFSLERNNSQPYYKNRRRCKICVRTTKRDRRTRQFCGAESENNEEDEEEINEPAQNYPKMPNMPEVSITVMRTTGETLHARQGIHQLASKLCLVCGRSYRYSHNARRHELTSHGFDRYTNKITPKKTLNHLQPKLRPNPFNPKARMMPNPISHKMQFLNKNMPTKIMPMNKVITPQRPIPIKTTSKTQNNLPYPLRIKALKDLQIKKKEPQILKTLLTSKPEVLVSEPEILNSGPESPETLISEPEIASFQVEAILTEPDADAYDDPQQGDEEVDEEMQNNQSQNYDTVDMDSDNEIEIARQQSIEQEGEENAEGEENIDHDDDNNEAGQSDNEKDVIDDTAEGQENMEEEDSVDIKPGDHIKDDEDQEDGEHEEVEMNHNEDDEDDDELPITLAPVVEINEGLQSNSFNSQANEEDEELDETVDPNETIDDAEQVKELDPDKTYVTKTQRDFIQKYRDIIQQINTKRCLCCDREHPRRKAVIQHLQKNGHKVPKHTCYNCVITFGHIGALLSHMRSNSCTNLWKIIYNENGITDDLVLEDEPKEVKVAYKDIFNARSYACKLCPAKFQLKQFIMKHVADTHEDGQSRVPLCCVHCRSRFKEKSLLKKHIRKGDCTVYIACDLCSDTFRNMQDFNDHALAIHAGSFDDNQSKCVDGRPTDCPLCGKKNSSYPNLVKHLKIIHAEEKPHYCQHCDAKYEQAADLNKHIYMEHSDRTLGMPPAEPDMSIVKEEAEEYHYSCTECNAIFETVDAWTDHQVAEHNQVAHHCDQCEKKFLRPSELAEHKNTHLRVKFYPCSVCPNSYSTPQKLSEHVQQSHPGIGAVAAAESEFFCDICIRAFKSRQAYSNHMRIHAKVPTTNRKPAAIKEGFAPQIIGKPIKQYPMVQPGFVSFKPNYNIPNAPYSCDICGKGFMHKKNIWKHKKVLHADILVDRHDSEENTMQASTEEEEFNPDENGAILSTPQFNSFNFANLNNAQQTPPEMPYECEICSKRFPLRTSLWKHKRAKHGIVNPSTSGSNEVSQPSASGEGSSRSSCTICRITFSDKKSYYRHRKNVHKSTVQMCKICGKPLSSTLELYEHLKAAHARELLGYNANQGSSKSQDVSQDMEPEYENDQESVDPSVDYQARYPCDTCGKQFVGLLALQNHQCINQVPSQPQTFDCEICHKSYTSISALKSHRGWHLRSPDGKAAANNSGLWMPQHKVTSKISKHEVIDPSQLAKVTHTPTPPPVTASAAKRRLPPEVEVTVVNPNKKLRSDDSVDMDMQNSGSMEDRYCTICDKEFTKRAAYQRHMDEVHQPNSVFCPVCDKSFTRKSTLLIHMKKHYESGEGSSSATGQGDDDYSCDLCGAQYDNDQALRAHRARHHGEDEESAEESDDGNVPVAPPGEFTCGQCGDGVATPRDLIAHRTMHATPTKFFCNICKVYFARALDLSSHTRARHADNEKVFFPCAMCDRFYMNKKSLQRHIEMAH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00017541;
90% Identity
iTF_00758469;
80% Identity
-