Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 4.9 1.9e+03 -0.9 0.1 22 32 57 67 54 83 0.72

2 7 0.0026 1 9.6 0.1 21 47 84 110 76 115 0.86

3 7 0.0026 1 9.5 0.0 21 46 112 137 108 144 0.89

4 7 0.015 6.1 7.1 0.0 22 45 141 164 136 169 0.89

5 7 0.046 18 5.5 0.4 26 51 173 198 166 200 0.78

6 7 0.46 1.8e+02 2.4 0.1 21 34 196 209 192 222 0.74

7 7 0.099 39 4.5 0.1 21 46 224 249 221 251 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	4.9	1.9e+03	-0.9	0.1	22	32	57	67	54	83	0.72
2	7	0.0026	1	9.6	0.1	21	47	84	110	76	115	0.86
3	7	0.0026	1	9.5	0.0	21	46	112	137	108	144	0.89
4	7	0.015	6.1	7.1	0.0	22	45	141	164	136	169	0.89
5	7	0.046	18	5.5	0.4	26	51	173	198	166	200	0.78
6	7	0.46	1.8e+02	2.4	0.1	21	34	196	209	192	222	0.74
7	7	0.099	39	4.5	0.1	21	46	224	249	221	251	0.89

Coding Sequence: ATGGAAGAAAAAGGTGCGGAAAAGGTAAAGAAAGACGAAGAAAACGATAACAACGAAGACGTCAGTGACATCGAGGTTTTTCTCAAAATCGATTTCAAGGAAGACCCTCAAGTCCAAAATAAAGCTCAAGGATCGTCGATAAGTATCTTCGAAGATGTTGCATTGGGGGAGAAGCCATACAGCTGTGAGGTCTGCGAGAAAAGGTTCCCCTTGGCAACTCATCTTAAGATCCATATGAGAGTCCACACTGGAGAGAAGCCCTACAGCTGCCAAGTCTGCGGGAAGCAGTTTACACAAGCGAGCAACCTCAGAAGCCACACTCGGATCCACACCGGGGAGAAACCGTACAGCTGCGAAGTCTGCGGGAAAAACTTCACACAAGGGAGCAACTTGAGAAGCCACATGCGAATCCACACAGGAGAGAAGCATTTCACATGCGAAGTCTGCGAGAAGAAGTTTACAGAAGCGAAAGCTCTCAGAAGGCACATGAGTTTCCATACCGGGGAAAACCTTTATTGCTGCGAAGTTTGCAATAAGAAGTTCGCCGTCGTCAATAACCTGAGGAGACACATGAGAGTTCACACTGGAGAGAAGCCGTTCACTTGCGAAGTCTGCAAGAAGAACTTTACAGATATCAGCACTTTAAAAGGGCATATGATCATCCACAGCGGGGAAAAGCCCTACAGCTGCCAACTATGCGTTAAAAAGTTCTACAGAGCATCGAATCTCAAGAGCCATATGAGAATCCATAAATAA
Protein Sequence: MEEKGAEKVKKDEENDNNEDVSDIEVFLKIDFKEDPQVQNKAQGSSISIFEDVALGEKPYSCEVCEKRFPLATHLKIHMRVHTGEKPYSCQVCGKQFTQASNLRSHTRIHTGEKPYSCEVCGKNFTQGSNLRSHMRIHTGEKHFTCEVCEKKFTEAKALRRHMSFHTGENLYCCEVCNKKFAVVNNLRRHMRVHTGEKPFTCEVCKKNFTDISTLKGHMIIHSGEKPYSCQLCVKKFYRASNLKSHMRIHK

Sequence clustering based on sequence similarity using MMseqs2