Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.2 78 3.5 0.0 21 44 5 28 2 33 0.82

2 9 0.00094 0.37 11.0 0.0 21 44 33 56 22 59 0.89

3 9 2.6e-05 0.01 16.0 0.0 21 49 61 89 56 92 0.84

4 9 0.023 9.2 6.5 0.0 21 44 89 112 84 116 0.89

5 9 0.00041 0.16 12.1 0.0 21 47 117 143 113 148 0.86

6 9 0.015 5.7 7.2 0.0 21 51 145 175 142 177 0.87

7 9 0.094 37 4.6 0.0 22 45 174 197 169 204 0.90

8 9 1.7 6.5e+02 0.6 0.0 26 44 211 229 198 232 0.76

9 9 0.0021 0.83 9.8 0.0 21 43 234 256 226 265 0.83

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.2	78	3.5	21	44	5	28	2	33	0.82
2	9	0.00094	0.37	11.0	21	44	33	56	22	59	0.89
3	9	2.6e-05	0.01	16.0	21	49	61	89	56	92	0.84
4	9	0.023	9.2	6.5	21	44	89	112	84	116	0.89
5	9	0.00041	0.16	12.1	21	47	117	143	113	148	0.86
6	9	0.015	5.7	7.2	21	51	145	175	142	177	0.87
7	9	0.094	37	4.6	22	45	174	197	169	204	0.90
8	9	1.7	6.5e+02	0.6	26	44	211	229	198	232	0.76
9	9	0.0021	0.83	9.8	21	43	234	256	226	265	0.83

Coding Sequence: ATGACCCACACAGGAGAAAAGCCATTCAAATGTGACATCTGCGATGCCATGTTTGCAGAATTAGGCAAATTGAAAATACATATCAGAACTCACACAAAAGAGAAGCCTTATAAATGTGAAATGTGCGACGCAACGTTCACACAGTCATTCAATTTGAAACTACATATCAGGAGCCACACAGGAGAGAAGCCATACAAATGCGATTTCTGTGATTCTATGTTTAGGTATTCAACTAATTTAAAACGACATATGAGCATCCATTCTGGAGAGAAGCCATATAAATGTGATATCTGCGATACCAATTTTGCACGTGCAAACAGCTTGAAAAGACATATTATGACCCACACAGGAGAGAAGCCATTCAAATGTGATACCTGTGGTGCCACATTTTCGCAGTCAACTAATTTGAAAAATCATATTATGATCCATACAGGAGAGAAGCCATTTAAATGTGATTTCTGCGATGCCGCATTTATTGAATCAAAGAAATTAAAATCACATATTAGAATCCACACTGGAGATAAGCCATTCAAATGTGATTTCTGCGAATCCGCTTTCACAGAGTCATACAGTTTGAAAAGACACATCAAGACCCATACAGAAGAGTCCAAAGGTACTCAAGAAAAGTTCAAATGTGACATCTGCGATTACACGTTTACACGGTCATCCCATTTGAAAAATCATATTATGAGCCATTCAGAAGAAAAGCCATTTAAATGTGATATCTGCAATGCCACATTTAAGTATTCAGGGAGTTTGAAAAAGCATGGGATCATCCACACAGGAGAAAAGCCATTTAAATGA
Protein Sequence: MTHTGEKPFKCDICDAMFAELGKLKIHIRTHTKEKPYKCEMCDATFTQSFNLKLHIRSHTGEKPYKCDFCDSMFRYSTNLKRHMSIHSGEKPYKCDICDTNFARANSLKRHIMTHTGEKPFKCDTCGATFSQSTNLKNHIMIHTGEKPFKCDFCDAAFIESKKLKSHIRIHTGDKPFKCDFCESAFTESYSLKRHIKTHTEESKGTQEKFKCDICDYTFTRSSHLKNHIMSHSEEKPFKCDICNATFKYSGSLKKHGIIHTGEKPFK

Sequence clustering based on sequence similarity using MMseqs2