Basic Information

Insect: Ophion ventricosus
Gene Symbol: lola
Assembly: GCA_963932345.1
Location: OZ010714.1:9413227-9418128[-]

Transcription Factor Domain

TF Family: BTB
Domain: zf-C2H2|ZBTB
PFAM: PF00651
TF Group: Zinc-Coordinating Group
Description: The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.2e-29 3.9e-27 94.8 0.1 1 100 22 117 22 121 0.94

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.2e-29	3.9e-27	94.8	0.1	1	100	22	117	22	121	0.94

Sequence Information

Coding Sequence: ATGGAGGACGACCAGCAGTTCTGCCTAAGGTGGAACAATCATCAGAGTACGCTCATCCAAAACTTCGACACACTCCTAGAGAGCGGCACGTTGGTCGACTGCACCCTGGCAGCGGAGGGGAAGTACCTAAAGGCCCACAAAGTAGTCCTCTCCGCGTGCAGTCCGTACTTTGAGGGCCTTCTCAGCGAACACTATGACAAGCACCCTGTCTTTATATTAAAGGACGTTAAGTTTAAAGAACTGAAAGCCATGATGGACTACATGTACAGGGGAGAAGTGAATATCTCCCAGGACCAATTGGCAGCCCTCCTAAAAGCGGCCGAGTCGTTGCAAATAAAGGGCCTCTCGGAGAGCAAAACGGGGGGCAACAATAACGGCAGCAAAACGGACTCAGCCTCGTCGTCGTCGAGGCAACAACAGAAAGTGGTTGCGGCGCAGCCTACGGCACCGTCGTTGGACATTCCACACGCGTCTTCCGGTCTCACAATAGAAAAGAACAATAAAGTTCCTAGGCAGAGTATGGCACAGAGCTCGGTCGGCGATCTACCAGAAGACTCGGCAAGTCCTCAACTACCCAAGGGGCTCTCCTCCAGGGAAGGCTCGCAAAGTCCGAcatcgagaaagagaaagagattcAGAAGAAGAAGCGTCGGGGACGACAACTCGATCGAGAATCACGATGCCTCGAACTCGAGCGATATGCCGCAACAAATGAGCGTACCCTCACTCGGTATCGCACCAGTTGCAGACGAAAAGACTCACACCGATCAGACCGATCCCCTCGGCAGATCCGCGCTTATGCAACAGCTGACCAAACCCGCCGAGGACATGTTACACTTACCACTCGAAAAACCTGAGCCTACCGAAAGCCTGATCGAGCCAAAGTCCGAGTACCTGGAGGATAATGAGGAGAGCGTCGAAGATCTGACGCTCGACGACGATATGAACGACCTCAATGAAATGGAACAAGACAACAACAGAGCCGGCCCGTCCCACGATCCCTCCCAACATCCCGGTGGGGGGTCGATCTCGCGGTATCGCGGCACGAGTTCCGGCGTAACGATTGCCGCCGTCGCCGGCACGGTTGCCCGCGGCGACGACGACCACGCGCGATGGGCGTCCCATTTCCTCGATTATCGTAATAAAAAGACCACGAACACGAGACGTCCACGTCCGGACGTTGACGTAGGCGCGTTGCTTAAATCTCTCGCCAACAAGCAGGGCCGAAAGTATAGCTTAGACTCGGTTAAAATGTCGCTGGAGGCGATATTGCAGCAGGGCGTTAGCACCACCCACGCATCCGAGATGTACGGTATCAACCGTTCGACCCTACAGTTTTATCTGAAAAAATTGAACGTCGTCAGACGAAGATGGAGACAACCCGTGACCCTCGTACCTCAAGGACAATCCTGA
Protein Sequence: MEDDQQFCLRWNNHQSTLIQNFDTLLESGTLVDCTLAAEGKYLKAHKVVLSACSPYFEGLLSEHYDKHPVFILKDVKFKELKAMMDYMYRGEVNISQDQLAALLKAAESLQIKGLSESKTGGNNNGSKTDSASSSSRQQQKVVAAQPTAPSLDIPHASSGLTIEKNNKVPRQSMAQSSVGDLPEDSASPQLPKGLSSREGSQSPTSRKRKRFRRRSVGDDNSIENHDASNSSDMPQQMSVPSLGIAPVADEKTHTDQTDPLGRSALMQQLTKPAEDMLHLPLEKPEPTESLIEPKSEYLEDNEESVEDLTLDDDMNDLNEMEQDNNRAGPSHDPSQHPGGGSISRYRGTSSGVTIAAVAGTVARGDDDHARWASHFLDYRNKKTTNTRRPRPDVDVGALLKSLANKQGRKYSLDSVKMSLEAILQQGVSTTHASEMYGINRSTLQFYLKKLNVVRRRWRQPVTLVPQGQS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00266562;
90% Identity: iTF_01100510;
80% Identity: iTF_01103475;