Ostr023992.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Oligia strigilis
Gene Symbol
Foxd3
Assembly
GCA_951800025.1
Location
OX637558.1:15025686-15026582[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6e-41 9.8e-38 129.2 0.0 2 87 94 178 93 179 0.97

Sequence Information

Coding Sequence
ATGGAAGATTGTGATCTTGCCCAATACCGCGATATGATCATCGAGGGCGAACTTCCGCTGGACCTGAGACCGCCGCCGCGGCTGTACCTGCCGCACTACCTGCGCGACGACCGCGGCCCCGAGTACCCCCAGGACGACACCTACGTGTCCGTTGACGAGGACACTCCAGAAGTTCCACCGGCGTCCAGTGACTCAGAACGGTACGACGCCTCCAGCCCGACGGAATCAAAACCATCGACGCCAAAGAAACCAAAGCAGAAGTCGTCATCACAACTCATCAAGCCGCCTTACTCCTACATCGCACTCATCACGATGGCTATCCTACAGTCTCCACACAAAAAACTAACACTCAGTGGGATCTGCGAGTTCATCATGACGAGGTTTCCATACTACAGAGAAAAGTTCCCCGCCTGGCAGAACTCGATCAGGCATAACTTGAGTCTGAACGATTGTTTTATAAAGATTCCGAGGGAGCCAGGGAACCCGGGGAAGGGGAATTACTGGACGTTGGATCCTTTGGCTGAGGATATGTTTGACAACGGAAGTTTTTTGAGGAGGAGGAAGAGGTACAAGCGGCCGGCGCCATCGCTGCAGCATGCGCACGCGGTGGTGGCGATGCTGGCGCGCGAGGCGTACGCCCCGCTGCTGCCGCTGCCGTGCTACCTGCCGCCGACGCCACTGCTGTCGCTGCCGCGCCCGCCGCCGGCGACGCTCCGGCCCGTCCCGCTGCCGCCGCGCGTCGCCGAAACAACTGAACCACGAAGTAAGAGATCTCGAAACGGATTCTCTATTGAATCCATCATTGGTTCACAGGATAGTTCAATGAACGAGCCAAGGAGAAGTGCCTTCTCGCCTCTTCACCAAACCAACTGTCCGCCGGACGACTGGGCCAGATGA
Protein Sequence
MEDCDLAQYRDMIIEGELPLDLRPPPRLYLPHYLRDDRGPEYPQDDTYVSVDEDTPEVPPASSDSERYDASSPTESKPSTPKKPKQKSSSQLIKPPYSYIALITMAILQSPHKKLTLSGICEFIMTRFPYYREKFPAWQNSIRHNLSLNDCFIKIPREPGNPGKGNYWTLDPLAEDMFDNGSFLRRRKRYKRPAPSLQHAHAVVAMLAREAYAPLLPLPCYLPPTPLLSLPRPPPATLRPVPLPPRVAETTEPRSKRSRNGFSIESIIGSQDSSMNEPRRSAFSPLHQTNCPPDDWAR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00695284;
90% Identity
iTF_00715617; iTF_00771681; iTF_00851525; iTF_00374982; iTF_00907686; iTF_01525737; iTF_00809866; iTF_00273419; iTF_00726091; iTF_00274254; iTF_00808910; iTF_01119086; iTF_01230318; iTF_01118063; iTF_00300976; iTF_00951600; iTF_00111409; iTF_00176914; iTF_01116978; iTF_00301907; iTF_00444915; iTF_00373716; iTF_00299957; iTF_00973528; iTF_00448827; iTF_00850399; iTF_00382378; iTF_00318692; iTF_01245742; iTF_00284335; iTF_00034515; iTF_00035450; iTF_00869428; iTF_00185117; iTF_01463969; iTF_00008707; iTF_00009813; iTF_00147106; iTF_00120296; iTF_01092873; iTF_01246633; iTF_00124043; iTF_00037583; iTF_00906865; iTF_00121203; iTF_01093844; iTF_00123157; iTF_01439702; iTF_00363833; iTF_00745433; iTF_00622618; iTF_00757946; iTF_01440795; iTF_00905919; iTF_00431938; iTF_00621827; iTF_01425774; iTF_01491685; iTF_00636079; iTF_01151869; iTF_00677347; iTF_00806499; iTF_00994179; iTF_01020035; iTF_00931031; iTF_00932225; iTF_00447975; iTF_00682177; iTF_00681471; iTF_00428808; iTF_00818957; iTF_01429743; iTF_00819864; iTF_00427904; iTF_00462179; iTF_00342020; iTF_00155120; iTF_00325176; iTF_01463065; iTF_00021146; iTF_00156061; iTF_00772683; iTF_01173081; iTF_00077297; iTF_01134592; iTF_01135561; iTF_01534601; iTF_00042438; iTF_00038504; iTF_00049707; iTF_01259886; iTF_00326892; iTF_01221301; iTF_00185945; iTF_00000123; iTF_00000990; iTF_01487519; iTF_01075180; iTF_00924397; iTF_01179310; iTF_01180134; iTF_00072057; iTF_00017986; iTF_00783234; iTF_01166402; iTF_00383427; iTF_01139459; iTF_00449928; iTF_01285353; iTF_01361386; iTF_00171566; iTF_00785009; iTF_01538546; iTF_01362899; iTF_01424853; iTF_00785822; iTF_01377278; iTF_00017151; iTF_01332351; iTF_01192430; iTF_01569071; iTF_00323299; iTF_01334564; iTF_00683134; iTF_00794128; iTF_01342027; iTF_00122161; iTF_00858355; iTF_00787428; iTF_00859268; iTF_01358697; iTF_00290474; iTF_00341144; iTF_00063386; iTF_01010174; iTF_00180257; iTF_00840129; iTF_01115521; iTF_01129863; iTF_01495591; iTF_00957770; iTF_01337581; iTF_01494127; iTF_00249523; iTF_01176019; iTF_00204180; iTF_01496373; iTF_01141462; iTF_01156093; iTF_00197184; iTF_00790050; iTF_00194987; iTF_00942617; iTF_00947707; iTF_00355935; iTF_00354895; iTF_00651540; iTF_00874260; iTF_00875109; iTF_00875960; iTF_01338294; iTF_01339764; iTF_00345623; iTF_00818168; iTF_00011749; iTF_00012743; iTF_00960743; iTF_01220463; iTF_00720016; iTF_01302098; iTF_00072533; iTF_00640089; iTF_00146202; iTF_00647805; iTF_01025785; iTF_01027106; iTF_01028069; iTF_01029964; iTF_00888023; iTF_01030940; iTF_01029023; iTF_01359525; iTF_00113938; iTF_01312047; iTF_00113144; iTF_01317086; iTF_01316127; iTF_00172538; iTF_01435866; iTF_00667163; iTF_00425181; iTF_00237273; iTF_00830973; iTF_01360415; iTF_00637285; iTF_00822694; iTF_01501895; iTF_00441291; iTF_00908621; iTF_00157008; iTF_00823732; iTF_00404502; iTF_01197529; iTF_01340957; iTF_00706752; iTF_01279073; iTF_01125253; iTF_01503656; iTF_01282031; iTF_01081393; iTF_00006100; iTF_01124409; iTF_01279995; iTF_01281115; iTF_01502779; iTF_00075267; iTF_00076261; iTF_00832711; iTF_01526824; iTF_01385514; iTF_01388274; iTF_01387422; iTF_01386528; iTF_00124971; iTF_00408203; iTF_00364722; iTF_00207670; iTF_00208638; iTF_00708984; iTF_00751834; iTF_00074286; iTF_00468000; iTF_00723777; iTF_00467266;
80% Identity
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