Basic Information

Gene Symbol
-
Assembly
GCA_948474745.1
Location
OX419702.1:14791899-14804131[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.075 5.2 8.1 1.6 2 23 350 371 349 371 0.87
2 12 0.024 1.7 9.6 0.6 2 23 379 401 379 401 0.95
3 12 0.0024 0.17 12.8 0.6 1 23 405 427 405 427 0.97
4 12 7.4 5.2e+02 1.8 1.2 1 23 432 455 432 455 0.95
5 12 0.00078 0.054 14.3 0.5 1 23 459 482 459 482 0.95
6 12 0.15 10 7.1 0.4 1 22 496 517 496 525 0.94
7 12 0.005 0.35 11.8 0.8 3 23 541 562 540 562 0.96
8 12 9.3 6.4e+02 1.5 2.7 3 23 579 600 578 600 0.95
9 12 0.00038 0.027 15.3 2.7 2 23 616 637 615 637 0.96
10 12 0.0019 0.13 13.1 1.2 2 23 643 664 643 664 0.97
11 12 0.00027 0.019 15.8 4.8 1 23 670 692 670 692 0.98
12 12 4.3e-06 0.0003 21.4 1.3 1 23 698 721 698 721 0.96

Sequence Information

Coding Sequence
ATGGTGGTATATTGCTGTGTTAATGGTTGCGGTAAAACCAGTAAAGATAAAAAGAAAAATCCAAATTCAGCGGTATCGTTTCACGTGTTTCCTGCAAATAAAGAACTTAGAAGCAAATGGCTGAGAGCTATAGGACGTCCAAACTGGTCGCCTTCGAACCATACCCGAATTTGTAGCGCGCATTTCACCTACGAACAAATCAACCACGATGGCTGCAAAATAAGAATAAAGGATGATGCTGTACCTGTTTTATTATTACCTCTAAACTCCAACTTTGAAGCATCAAATGTGGAAGTTTGCAGGATTTGTTTGTCCATAGACGTCAAGCTGTACAGTCTACAAGATACACACCTGGGGACATGTATGAAGTCTATTGCTGGATTAAGTCTAAATGGAATGGACTTGGAAGATATGCCACAATACGTTTGCTATCAATGTGCACCAAGCCTGGTAAAATGCAACCAACTCATAGAGAAATGTATCACCTCTCAGGCAACTTTACTGGATATATTTGCTAAGAATGGACAGATATCAAAAGATCTGATAAAAGAACAGAATAGATCCCAACCGATCTTGAAGTCATTAGAGAATAGATTTGTATTAAATGATCATTTGCTGAAATATGATGACGACAACACTCCTTCGCTATTTACTACTGAAGATTCCATAGAGAATGATCATATTATTAATTATAAAAGAGAAGATGGTACAAATACTGATGCAGACACGCATCTCAATAATAAGGAATGTCAAGTTGAAGCAAATGAAAGTGAATTTCATGAAGTTAATGATGTGGTGGTGGAAAAAAATAAAATAAATTCTTCTGACGATCTCCATAAGGATTCGAGTTCAAATGCTCAGAAAGAGGAATTAGAAATTCAAGTTATGCACACAAAAAATATGTCTGCAGGGAGAAATCATGATTTAACGCCAGATGAAACAAATATGCTGAAATACTTCGATATTGTCCGATTATCATTACATGAACAAATTCGAGAATGGGAAAAGAGTACAGTTGGTCGTCCACTAATAAGTGACACTAACCTACAATGTGAGATCTGTAAAAAATCATTCGCGAGTGTCAACTTTCATCGCGTTCATGTTAGACAGCACGAGCCGGGTTTTGGTCGAGCGCAGTGCCCTATATGCAAGCTAAGATTTAAAAGCACTGCCTTGGCGACTTCGCACTCCAAACGCGCACACAGCAAGAAATTCTACTGCAAGATGTGCCCGAAGGCTTTTAACAATGTAATGGTAGCCAAAAAGCACCAGCGCTGGCATTCAGGCTACTTATACAAATGCGATTCATGTGCGTTCTCAACGCTACACGAGTCTTCACTGGGCATCCACAAGCGGCGTGCGCACGCTAACGCGCATGCGTGCGCGCTGTGCGGACGTGCCTATGGTACACGGAAAGGATTGAACGCGCATATACATACCGCACATAGTAATATTAAGGTTAAAGACATCAAAGGCAGTAAGGAGTATCGTTGTGAACAATGCAGCATCGACTTTGCGTCGGAAGGCGCAAGACGAATACACATACTTACATCCATTCAACATAGGAAGAAGCATGATTTGTGCGACACCGCCGTCCAAGAGCCAAACCTACCCAACATTTGCGAGAAGTGCGGCGTAGAATGTTCTACGGCCAAAGAGTTGTCTTGGCACAAGAAGTCGGAGCACCCTCGCCCTCGGAGTAAAGACCATCCGCCGCCAGGATACCCTAAAGACTGCGAACTTTGCGGTGTCACGCTTCCCAACCGCAAGAAACATTGGCACCATGTTCGAAAGCAGCATCCCGAGAACATGGAGATCTACAAACGGGTTCAAACCATCACTTGTATTTGTGATACTTGCGGGAAAGGCTTTCAGAACTCAACAAAGCTCCGCCTCCACCAGCTCCGGCACGGCAGCCCCGCGGCGCGCTGCCCGCGCTGCCCGCGCGTGTGCTACGACAAGTACGCGCTGGCTGCGCACGCGCACACGCACCGCGCCGACAGGCCGCACCAGTGTCGCACGTGTGGGGCGGCCTTCAAGCAGCGCTGTAACTTGGACAGGCATTATAGAGTTCATTCAGACATCGCTACATTCGAGTGCACGATTTGCGGCAAAAAGTTTAAATACTCGACAAGCTTGAAACTTCACGTGAACTATGTGCATAACAAGTTACCTTACCCGAAAAGGAAGAAAAGAATCAAATCCGTGAAGAATGCAAGTGATTCGTAA
Protein Sequence
MVVYCCVNGCGKTSKDKKKNPNSAVSFHVFPANKELRSKWLRAIGRPNWSPSNHTRICSAHFTYEQINHDGCKIRIKDDAVPVLLLPLNSNFEASNVEVCRICLSIDVKLYSLQDTHLGTCMKSIAGLSLNGMDLEDMPQYVCYQCAPSLVKCNQLIEKCITSQATLLDIFAKNGQISKDLIKEQNRSQPILKSLENRFVLNDHLLKYDDDNTPSLFTTEDSIENDHIINYKREDGTNTDADTHLNNKECQVEANESEFHEVNDVVVEKNKINSSDDLHKDSSSNAQKEELEIQVMHTKNMSAGRNHDLTPDETNMLKYFDIVRLSLHEQIREWEKSTVGRPLISDTNLQCEICKKSFASVNFHRVHVRQHEPGFGRAQCPICKLRFKSTALATSHSKRAHSKKFYCKMCPKAFNNVMVAKKHQRWHSGYLYKCDSCAFSTLHESSLGIHKRRAHANAHACALCGRAYGTRKGLNAHIHTAHSNIKVKDIKGSKEYRCEQCSIDFASEGARRIHILTSIQHRKKHDLCDTAVQEPNLPNICEKCGVECSTAKELSWHKKSEHPRPRSKDHPPPGYPKDCELCGVTLPNRKKHWHHVRKQHPENMEIYKRVQTITCICDTCGKGFQNSTKLRLHQLRHGSPAARCPRCPRVCYDKYALAAHAHTHRADRPHQCRTCGAAFKQRCNLDRHYRVHSDIATFECTICGKKFKYSTSLKLHVNYVHNKLPYPKRKKRIKSVKNASDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01526557;
90% Identity
iTF_01095452;
80% Identity
iTF_01094107;