Basic Information

Gene Symbol
-
Assembly
GCA_029955525.1
Location
JARPMR010000029.1:13985783-13990904[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0003 0.03 16.2 3.0 1 23 172 195 172 195 0.98
2 17 0.00012 0.012 17.5 0.6 1 23 204 227 204 227 0.96
3 17 0.016 1.7 10.7 0.4 2 23 240 262 240 262 0.97
4 17 0.0012 0.12 14.3 2.8 1 23 271 294 271 294 0.97
5 17 5.9e-05 0.0059 18.4 1.3 1 23 306 329 306 329 0.97
6 17 0.00022 0.022 16.6 0.9 2 23 361 383 360 383 0.96
7 17 0.0006 0.06 15.3 0.7 2 23 393 415 392 415 0.96
8 17 0.2 20 7.3 0.8 2 21 420 439 419 440 0.89
9 17 0.0016 0.16 13.9 3.7 2 21 445 464 444 467 0.94
10 17 0.15 15 7.7 2.2 3 23 477 498 476 498 0.95
11 17 0.0061 0.61 12.1 2.7 1 23 503 526 503 526 0.94
12 17 0.00017 0.017 17.0 1.4 2 23 537 559 536 559 0.96
13 17 0.00029 0.03 16.2 0.5 1 23 585 608 585 608 0.94
14 17 8.8 8.9e+02 2.1 0.4 2 23 615 635 614 636 0.79
15 17 0.019 1.9 10.5 1.6 2 23 642 663 641 663 0.97
16 17 0.028 2.8 10.0 0.1 1 23 729 751 729 751 0.97
17 17 0.28 29 6.8 2.0 1 23 757 780 757 780 0.96

Sequence Information

Coding Sequence
atgtCAGTAAAAGAGGAGAAACctgatataaaaaatttaaaaactgaaaACATAGATGATGACAAGAGAAAAGATCCAACCACTTTGTTGCCAGAGGAGCCAATGTCGTACGAAATTAaggtgaagaagaagaagaaaaaaaagaaaaagaaagatttaATGGAAGATCCTTTCAAAGATATAGAGGAAAGAGTCAAATTGCCAACTCAGGCATTTTATGATCCAGTCACGGAAACTGATCCAGAACCGTCAGTTCTTGATCCAGAAGTTAATATCAAGGTTGAGAATATTGAAGTGGAGCTCGACTTCAATGatTTTGCAAATGACAACGGCCTAATGGTAGAGGGTCCTCAAAGTGAAGAGAGTCAAGAACCGGCTGTGAAAATAGAAGAACAGAACCATGAAGCTGTACTTCTAACTTTTGAAAGTATACTAAAAGAGAAAAACCTCTTACGTTACAATCCTGATGAAAATGTCTTAGGTTATAATCTCAACACAGCACCCGCACCAAATTACGTGTGCAAAGTCTGCCATCTAGTCTTTCAAAGTCCGAAAACTTTAAGAATGCATCAAAAAAGAAAGCACAAAGTATACCAAAAGTCATTTAAACATATTTGTGACTACTGTGGTATGGCTTATGAACAGAAAAACAGTCTCGTCGCTCACATAAAGAGGAAACACGGTCCCAACTCCGTGCCTGAAGATCCCCAAGAAAGAACATGCGATGTATGTGCTCTGGTTTTCAAAGGATATGCAAGATTGCGTATGCACATGAGAAGGAAGCATGGATCGTTTGAAGAGTCTTTCAAACATGTTTGCAATGAATGTGGACTAACATACGATAAACATAGAAGTTTAGTGGTTCATATGCAaagaaaacattcaaatgaacccaaaccagtgTTGGACACTTGGTATAATTGCCCGTTCTGCCCCAAGGTATTTACTAAAAGAGAAACATACGCGCGGCACGTACAAAGAAAACACCGCATTAACGATGAAGAGAATAATAAACAAGACGAAGGAAAGGAGGAATTgaaggatttattaaattgcaAGAATGAGCAAACTGGTGAAATTATGTGCAAGCAATGCCCTCTAGTTTTTTCGTCATTAAACTTCTTGAAATTGCACATGAGAAGAAAGCACAATGCGTTGAAAGACAATTTTAAATTGAAGTGTGTGATATGTAATCTCTCGTATGATAAAGTCGAAAGTTTGAAACGTCATATCAGAAGGAAACATGATAAGGAATTGTATTGTGAGGTTTGCGAAAAACATTTTGAAACGAGAGAAATGTATCTTGGACACACACATACTAAAGTAATTCAAGAATGTCATATTTGTGGTTTAGTTTTCGCTTCTCGAGGGGGTTTGTGTAAGCATTTGCGGTGTACTCACAAAATTGAGACGCCAAAAAcggttttctgtgatttatgCACCGAAAGTTTTCACGATAAACGCCAGTTAAAACCTCATTACATGAAAGTCCATTTAAAAGTGTCCTATACGTGTCGATTTTGCAAAAAAATCTTTAGAGCAAAAGAGAGTTATAGACGCCATGTTTTATTGAAACATCCGAATTTTAATGAAAGTCAAAGCAAGCAGAAATGTGACCAGTGCACAGAAACGTTTACGGATGAGTTTGAATTGTGTAAGCACATCAATATAGCTCATAGAGTAACCAAAACTGAGATAGGTGCTCCGACTTTAATAGAAATTAAAAAGGAAGAAGTGGACATACCACCTTCCTTTCAATGCAATAAATGTCCTGAAAACTATGAGAGTTGGGATCAATTAAAACTGCATTATGAGCAAAACCATCAAACAATTACTCACACCCAGTGTCAAGTATGTGGAGAAATGGTGCCAGAACTAGAAATCCAGAAACATATAAAACTACACCATACAGATACAAAAGTACAGTGTAGATTTTGTGAATTTGAAACATCCAATCGTTCGAGTATGACCCAACATATGTTAAGGCATAAAAATGCAACAACTCTACACTGTGACTTTGCCGGCTGTAGATACAAAACTTATTATGAGCTTGCCATGGAAAAACATAAGAGAAAACATGCAGACATAGGTGTAAAACTCCAGTGTTCACAATGTCCATTTCAGagtatgaataaatatattctaaaatATCATGAAGAGGCCCACGCGACCGGTAAAAAGAGATACATGTGTGATCAATGTGACTATGCGACCATATTACCAGCAAATTTAGTCCAACATAAATACAAACACTCTACAGAAAAGAGGTTTAAATGTGAAGTCTGTCCATTCGCCACGAAGTACAACACGTCATTACGTTTTCACGTAAAGAAAAAACATTGTGATCTCCCTACATTCAAATTAATGTCtaagtaa
Protein Sequence
MSVKEEKPDIKNLKTENIDDDKRKDPTTLLPEEPMSYEIKVKKKKKKKKKKDLMEDPFKDIEERVKLPTQAFYDPVTETDPEPSVLDPEVNIKVENIEVELDFNDFANDNGLMVEGPQSEESQEPAVKIEEQNHEAVLLTFESILKEKNLLRYNPDENVLGYNLNTAPAPNYVCKVCHLVFQSPKTLRMHQKRKHKVYQKSFKHICDYCGMAYEQKNSLVAHIKRKHGPNSVPEDPQERTCDVCALVFKGYARLRMHMRRKHGSFEESFKHVCNECGLTYDKHRSLVVHMQRKHSNEPKPVLDTWYNCPFCPKVFTKRETYARHVQRKHRINDEENNKQDEGKEELKDLLNCKNEQTGEIMCKQCPLVFSSLNFLKLHMRRKHNALKDNFKLKCVICNLSYDKVESLKRHIRRKHDKELYCEVCEKHFETREMYLGHTHTKVIQECHICGLVFASRGGLCKHLRCTHKIETPKTVFCDLCTESFHDKRQLKPHYMKVHLKVSYTCRFCKKIFRAKESYRRHVLLKHPNFNESQSKQKCDQCTETFTDEFELCKHINIAHRVTKTEIGAPTLIEIKKEEVDIPPSFQCNKCPENYESWDQLKLHYEQNHQTITHTQCQVCGEMVPELEIQKHIKLHHTDTKVQCRFCEFETSNRSSMTQHMLRHKNATTLHCDFAGCRYKTYYELAMEKHKRKHADIGVKLQCSQCPFQSMNKYILKYHEEAHATGKKRYMCDQCDYATILPANLVQHKYKHSTEKRFKCEVCPFATKYNTSLRFHVKKKHCDLPTFKLMSK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01021537;
90% Identity
iTF_00802149;
80% Identity
-