Ospi008070.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Odynerus spinipes
Gene Symbol
Mef2
Assembly
GCA_032403825.1
Location
JAIFRP010000084.1:2027768-2032260[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.8e-28 2.1e-24 84.4 0.4 1 48 10 57 10 57 0.99

Sequence Information

Coding Sequence
ATGGGTCGGAAGAAGATTCAAATCTCGCGCATCACGGACGAACGGAACCGTCAGGTGACCTTTAACAAGAGGAAATTCGGGGTAATGAAGAAGGCGTACGAATTGTCGGTACTATGCGATTGCGAGATTGCGCTGATTATCTTTAGTTCGAGCAACAAGCTGTACCAGTATGCGAGCACCGACATGGACAAGGTCCTCCTCAAGTACACCGAGTACAACGAACCCCACGAGTCCCTTACCAACAAGAATATCATCGAGGCGCTCAACAAGAAGGAACATAAGGGTGCCATGTCTCCGGAGAGTCCGGAACCCGACGCGATCGAGTACAATCTCACCCCGCGCACCGAGGCGAAGTACACCAAGATCGACGAAGAATTTCAGATGATGATGCAGAGGCACCAGAATAATGGCACCAGGGGGATGGGCCAATCTAATTACACATTACCTGTATCTGTGCCAGTGAATAGTTATGGCGAATCTCTTCTTGGATCTAGTCCTCAAATGGCACACACCAGCATTTCTCCAAGACCGTCATCGTCTGAAACAGATTCAGTATATCCACCAGGAGGAATGTTAGAAATGAGCAACGGCTATCCTCCGTCAGCCTCTCCGTTAGGTGGATCACCTAGTCCAGGACCTTCACCAGCGCTCGGAGTTGGTGGAGGTAGCGCGAATAAAGGCAGTAATCCATCAAGGCATTCGCCGCAACCACCGCCCCCTCCACCACCACATCCTCATAGACCCAACCTTCGAGTAGTTATACCGACACCTCTCACACAACCACTCTCCGAGGACACCAATTACGACGGCGGTCATACACAATCTGCATTGAATACACCGGTAGTAGCATTACAGACACCATCGGTACCAGCTGGGTATTCCAGTTTTGGTCCCACGGACTATTCCTCAGATCTAGGAAGTCTTGCATGGTCTCATCAGAGGTACGTTGATGACTTATCAATGTATTCGGCAGCCACCATGTCCAGCATCAGCGGTCTTCCTCATTTAGCTGTGTCGAGCAGCACTCCTCCGCCATCCACGTCGCCTTTAcctgttaaaataaaaagtgaaccGATAAGTCCGCCCCGAGATCCTCACGGTGGTAACAGTGGTTCGAGCGGTGGCCCAAGCAATGCCAGTACTTTACATCATACAAACTTGAATATCGGTCCTTCGTCTAGTACCGGTGCTCCACCTCCACATCACGTACCTCATGGTGGCCCTCAGACGTTAAATTTAGTATCGAGCAGACCAAGCAGCAATCCACCACCATCCCACTCAGGAAGTATAACTCCGACAAATTTACCGTCCCCAGGTAGTGGGACGGTCGGTGATATCAGAAGCACGAGTCACGCCGGCAGTGGTGGTAATGGAGGAAATAGTTCGGATTATGAAAATGGACCACTCATGAAACGGTCCAGGATCACGGAAGGATGGGCGACTTAA
Protein Sequence
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDKVLLKYTEYNEPHESLTNKNIIEALNKKEHKGAMSPESPEPDAIEYNLTPRTEAKYTKIDEEFQMMMQRHQNNGTRGMGQSNYTLPVSVPVNSYGESLLGSSPQMAHTSISPRPSSSETDSVYPPGGMLEMSNGYPPSASPLGGSPSPGPSPALGVGGGSANKGSNPSRHSPQPPPPPPPHPHRPNLRVVIPTPLTQPLSEDTNYDGGHTQSALNTPVVALQTPSVPAGYSSFGPTDYSSDLGSLAWSHQRYVDDLSMYSAATMSSISGLPHLAVSSSTPPPSTSPLPVKIKSEPISPPRDPHGGNSGSSGGPSNASTLHHTNLNIGPSSSTGAPPPHHVPHGGPQTLNLVSSRPSSNPPPSHSGSITPTNLPSPGSGTVGDIRSTSHAGSGGNGGNSSDYENGPLMKRSRITEGWAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00721218;
90% Identity
iTF_01512788; iTF_01513429; iTF_01514782; iTF_01514111; iTF_01270461; iTF_00214977; iTF_00221217; iTF_00231940; iTF_00217029; iTF_00218373; iTF_00225192; iTF_00217706; iTF_00219754; iTF_00223146; iTF_00231275; iTF_00221869; iTF_00214350; iTF_00225870; iTF_00306222; iTF_00228623; iTF_00215665; iTF_00227921; iTF_00222483; iTF_00232563; iTF_00223830; iTF_00226551; iTF_00220536; iTF_00230649; iTF_00216347; iTF_00229307; iTF_00219068; iTF_00224508; iTF_00227232; iTF_01261793; iTF_00015330; iTF_00014677; iTF_00015997; iTF_00016639; iTF_00128930; iTF_00129699; iTF_00126668; iTF_00127412; iTF_00125880; iTF_00128156; iTF_01068930; iTF_01066211; iTF_01066896; iTF_01067568; iTF_01070321; iTF_01065525; iTF_01069623; iTF_01068254; iTF_01355266; iTF_01407234; iTF_00181924; iTF_01409065; iTF_01405652; iTF_01408160; iTF_00417515; iTF_00769580; iTF_00625454; iTF_01169127; iTF_01228975; iTF_01228329; iTF_00182579; iTF_00181262; iTF_01477523; iTF_01087156; iTF_01523316; iTF_00756597; iTF_00109784; iTF_00385272; iTF_00452537; iTF_01520185; iTF_01015770; iTF_00765536; iTF_00885064; iTF_01254752; iTF_01271169; iTF_01269754; iTF_01267518; iTF_00024578; iTF_00866660; iTF_00861093; iTF_00861830; iTF_00863910; iTF_01539560; iTF_00865961; iTF_00675978; iTF_00762507; iTF_00088780; iTF_00087117; iTF_00117965; iTF_00760944; iTF_00763185; iTF_00864593; iTF_00087954; iTF_00085332; iTF_00862517; iTF_00141783; iTF_00860343; iTF_00865272; iTF_00142426; iTF_00863226; iTF_00086235; iTF_00084508; iTF_00183900; iTF_00962468; iTF_00963147; iTF_00964435; iTF_00961781; iTF_00963807; iTF_00982245; iTF_01418307; iTF_01419596; iTF_01420889; iTF_01417659; iTF_01070983; iTF_00302986; iTF_01122389; iTF_01123021; iTF_00140540; iTF_00730691; iTF_00729256; iTF_01245177; iTF_00730011; iTF_00279917; iTF_00280569; iTF_00868068; iTF_00868751; iTF_00867354; iTF_01354564; iTF_01268229; iTF_01120166; iTF_01099145; iTF_00183242; iTF_00141189; iTF_00965991; iTF_01269002; iTF_00754603; iTF_01077419; iTF_01232365; iTF_01234982; iTF_01233610; iTF_01232958; iTF_01424336; iTF_01406450; iTF_01422881; iTF_01421513; iTF_01422187; iTF_01423614; iTF_00898703; iTF_01266839; iTF_00264954; iTF_00264225; iTF_00684123; iTF_00684747; iTF_01454044; iTF_00360862; iTF_00360171; iTF_00233184; iTF_00229983;
80% Identity
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