Basic Information

Insect: Exephanes ischioxanthus
Gene Symbol: Mef2
Assembly: GCA_958510785.1
Location: OY294018.1:14295762-14300648[+]

Transcription Factor Domain

TF Family: SRF
Domain: SRF domain
PFAM: PF00319
TF Group: Helix-turn-helix
Description: Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.8e-28 3.2e-24 84.5 0.4 1 48 10 57 10 57 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.8e-28	3.2e-24	84.5	0.4	1	48	10	57	10	57	0.99

Sequence Information

Coding Sequence: ATGGGTCGGAAGAAGATACAAATATCTCGTATAACCGACGAGAGGAATCGTCAGGTTACGTTTAACAAGAGAAAATTTGGCGTTATGAAGAAGGCTTACGAGCTCTCGGTACTTTGCGACTGCGAGATAGCGCTTATTATCTTCAGTTCGAGCAACAAACTTTATCAATATGCGAGCACCGACATGGACAAGGTTCTTCTAAAGTACACGGAGTACAACGAACCCCACGAGTCCCTTACCAACAAGAATATTATTGAGGCGCTTAACAAGAAGGAGCATAAGGGTGCCATGTCCCCGGAGAGCCCGGAGCCTGACGCGAACGAGTACAATCTAACACCAAGGACCGAAGCAAAGTATACAAAGATCGACGAGGAGTTCCAAATGATGATGCAAAGAGGCCAGCACAATGGCACCAGGGGTATGGGTCAATCGAATTACACGCTACCTGTGACAGTACCGGTGAACACTTACGGAGAATCACTCCTAGGGTCTAGTCCTCAAATGGCGCACACCAGCATCTCCCCAAGGCCGTCTTCGTCTGAAACTGATTCAGTTTATCCACCCGGAGGAATGTTGGAAATGAGTAACGGATATCCACCGTCGGCATCGCCATTGGGTGGATCGCCGAGTCCAGGACCATCTCCTGCCCTCGGTGTTGCAGGCGGCGGCAACAAGGGACCGAACTCGTCTCGTCACTCCCCACAGCCACCCCCGCCACCGCATCCTCATAGAGCTAATCTACGAGTCGTTATACCCACGCCACTAACACAACCGCTCTCTGAAGATACCAATTACGACGGCGGTCACGCACAGAGTGCTCTGAACACACCGGTCGTCGCGTTACAAACACCGTCCGTCGCCGCTGGTTATTCCAGTTTCGGACCGACAGATTATTCCTCGGATCTTGGCAGTCTCACATGGTCGCACCAGAGGTACGTTGACGACTTGTCAATGTACTCGGCCGCCAGCATGTCGAACATCAGTAGCCTTCCTCACTTGGCGGTATCGAGCAGTACACCGCCGCCGTCCACATCGCCATTACCTGTGAAAATAAAGAGTGAACCGATAAGTCCGCCCCGAGACCAGCACGGCGGCAACAGCGGTACGAACGGCGGTCCCGGAAGTTCGAGCAATTTGCATCACACGAATCTGAGCGTGGGTCCaccgtcctcgtcctcgggtCAGCCGCCGCATCACGTTACGCACGGCGGGCCTCAAACGTTGAATCTAATATCGAGCAGACCAACGAGTAATCCACCGCCGTCGCACTCGGGCAGTATTACACCGACGAATTTGCCGTCGCCCGGTGGTGGTAACGTCGGCGACATGAGAACGAGTCACGGAGGGGGCGGCAACGGTGGCAACAATTCCGACTACGAGAACGGACCGTTGATGAAACGCTCGAGAATCACGGAAGGCTGGGCCAATTAA
Protein Sequence: MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSSNKLYQYASTDMDKVLLKYTEYNEPHESLTNKNIIEALNKKEHKGAMSPESPEPDANEYNLTPRTEAKYTKIDEEFQMMMQRGQHNGTRGMGQSNYTLPVTVPVNTYGESLLGSSPQMAHTSISPRPSSSETDSVYPPGGMLEMSNGYPPSASPLGGSPSPGPSPALGVAGGGNKGPNSSRHSPQPPPPPHPHRANLRVVIPTPLTQPLSEDTNYDGGHAQSALNTPVVALQTPSVAAGYSSFGPTDYSSDLGSLTWSHQRYVDDLSMYSAASMSNISSLPHLAVSSSTPPPSTSPLPVKIKSEPISPPRDQHGGNSGTNGGPGSSSNLHHTNLSVGPPSSSSGQPPHHVTHGGPQTLNLISSRPTSNPPPSHSGSITPTNLPSPGGGNVGDMRTSHGGGGNGGNNSDYENGPLMKRSRITEGWAN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00905383; iTF_00059416; iTF_00738305; iTF_00089505; iTF_00200710; iTF_00652673; iTF_01207315; iTF_01497371; iTF_00343135; iTF_01261793; iTF_00015330; iTF_01228329; iTF_01228975; iTF_01477523; iTF_00014677; iTF_01015770; iTF_01454044; iTF_00015997; iTF_00016639; iTF_00214977; iTF_00221217; iTF_00231940; iTF_00217029; iTF_00218373; iTF_00225192; iTF_00217706; iTF_00219754; iTF_00223146; iTF_00231275; iTF_00684747; iTF_00221869; iTF_00214350; iTF_00225870; iTF_00306222; iTF_00228623; iTF_00215665; iTF_00227921; iTF_00222483; iTF_00232563; iTF_00223830; iTF_00226551; iTF_00220536; iTF_00230649; iTF_00216347; iTF_00229307; iTF_00684123; iTF_00219068; iTF_00224508; iTF_00229983; iTF_00227232; iTF_00233184; iTF_01271169; iTF_01269754; iTF_01267518; iTF_01422881; iTF_01421513; iTF_01422187; iTF_01423614; iTF_00128930; iTF_00129699; iTF_00126668; iTF_00127412; iTF_00125880; iTF_00128156; iTF_01068930; iTF_01066211; iTF_01066896; iTF_01067568; iTF_01070321; iTF_01065525; iTF_01069623; iTF_01068254; iTF_01418307; iTF_01419596; iTF_01420889; iTF_00866660; iTF_00861093; iTF_00982245; iTF_00861830; iTF_00863910; iTF_00865961; iTF_00762507; iTF_00763185; iTF_00864593; iTF_00862517; iTF_00865272; iTF_00863226; iTF_01417659; iTF_00868068; iTF_00868751; iTF_00867354; iTF_00141189; iTF_00675978; iTF_00117965; iTF_00760944; iTF_00141783; iTF_00142426; iTF_01268229; iTF_01234982; iTF_01233610; iTF_01232365; iTF_00965991; iTF_00024578; iTF_00183242; iTF_00360171; iTF_00625454; iTF_00183900; iTF_00360862; iTF_01070983; iTF_01169127; iTF_01099145; iTF_01409065; iTF_01406450; iTF_01405652; iTF_01408160; iTF_01269002; iTF_00754603; iTF_01077419; iTF_00088780; iTF_00769580; iTF_01123021; iTF_00898703; iTF_00391248; iTF_00087954; iTF_00085332; iTF_01512788; iTF_01122389; iTF_01513429; iTF_01089953; iTF_01514111; iTF_00860343; iTF_01498177; iTF_01266839; iTF_00109784; iTF_00385272; iTF_00452537; iTF_00264954; iTF_00264225; iTF_00086235; iTF_00084508; iTF_00087117; iTF_00140540; iTF_01270461; iTF_01232958; iTF_01514782; iTF_01254752; iTF_00397250; iTF_00398038; iTF_01355266; iTF_01407234; iTF_00730691; iTF_00729256; iTF_01245177; iTF_00730011; iTF_00279917; iTF_00756597; iTF_00280569; iTF_01001219; iTF_00451897; iTF_01354564; iTF_00181924; iTF_00182579; iTF_00181262; iTF_01393476; iTF_01389385; iTF_01394255; iTF_01392723; iTF_01391062; iTF_01391926; iTF_01390170; iTF_00060165; iTF_00773766; iTF_01379171; iTF_00962468; iTF_00963147; iTF_00964435; iTF_00961781; iTF_00963807; iTF_00841030; iTF_00302986; iTF_00058663; iTF_00174983; iTF_00174133; iTF_00175706; iTF_01539560; iTF_00417515; iTF_00882923; iTF_00879591; iTF_00881201; iTF_00880408; iTF_00881982; iTF_01306411; iTF_01299137; iTF_00295202; iTF_00298265; iTF_00296734; iTF_00295970; iTF_00828739; iTF_01199363; iTF_00291492; iTF_00297508; iTF_00292902; iTF_00293676; iTF_01475405; iTF_01473877; iTF_00629060; iTF_00439429; iTF_00292230; iTF_01120166; iTF_00254280; iTF_01395081; iTF_00266414; iTF_00253521; iTF_00265649; iTF_01473137; iTF_01474641; iTF_00829458; iTF_01130771; iTF_01508820; iTF_00718518; iTF_00719370; iTF_00050903; iTF_01129304; iTF_00263417; iTF_00262617; iTF_01048862; iTF_01048187; iTF_00294431; iTF_01198624; iTF_00996302; iTF_00996995; iTF_01560394; iTF_01303311; iTF_00047920; iTF_00980080; iTF_00011057; iTF_01413136; iTF_01200106; iTF_01424336; iTF_00633586; iTF_00057906; iTF_01255506; iTF_00393557; iTF_01087156; iTF_01523316; iTF_00414261; iTF_01057603; iTF_00938646; iTF_00939504; iTF_00438039; iTF_00728617; iTF_01488535; iTF_01489340; iTF_00459711; iTF_00378712; iTF_00438712; iTF_01412280; iTF_01411465; iTF_01414130; iTF_00046105; iTF_00046929; iTF_00159065; iTF_00770330; iTF_01520185; iTF_01537913; iTF_00676677; iTF_00460477; iTF_00252026; iTF_01000507; iTF_01364604; iTF_00255037; iTF_00252773; iTF_01273053; iTF_01273739; iTF_00168382; iTF_00350970; iTF_01003487; iTF_01006021; iTF_01004205; iTF_01005042; iTF_00379578; iTF_00687139; iTF_00381797; iTF_00316745; iTF_00317428; iTF_00377972; iTF_00937979; iTF_00765536; iTF_00885064;
90% Identity: iTF_01057603;
80% Identity: iTF_00059416;