Npro017649.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Noctua pronuba
Gene Symbol
egg
Assembly
GCA_905220335.1
Location
LR999921.1:3137455-3170099[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2 1.2e+04 -3.3 0.1 29 38 1780 1789 1748 1790 0.66
2 2 3.2e-13 1.9e-09 37.7 0.0 4 73 1821 1883 1818 1887 0.88

Sequence Information

Coding Sequence
ATGAGTGATAAGGAAGAAAAGGACAATAAAGAGAAAGAAATTCCGCGAACTAGTCAAGACGGAGGTTCCAACAACCCAGAAACATTAACTGAGGGTAATGTACTATCTTTAAATTCGAATAAAAATACCGAAAATAGTAGCACCATATCTGAAAATAAGCATAGATCAGCAGCTATAGAAGGCTCTGGAGATAATGCCGGCCGCACTGTTCAAGAAAACTCTGAACTTGATAAAATTGAAGCAGAATTGACTGAAATGTCAAAGGAGTTAATAAATACTGATGCAGGCATAGGTAGTGGTGATTATACAGCCAAAGCAAAGGACAGCGACGTAGATGATAAAATAATTGAGGACATAGATACTGAAATAAATGCTAAAACATCTAAATCCGATGTAATTGCGGAGAAAGACGGAAGTAATGATGATCTTCTTGACAAATGTGATGATAGAGAACTCAAAAAGGCTGATGATTTTGACGAATTTGAAGATGAAGATATGCAACTAAGATGGGATGAGGATGATGATGCTAGCAATCAACATCAGGGTGATGACAATGCAAATGTTGGCAATAAGAACGATAGTATTCTGTCAGAAGACCAACTTTTGGAAGATTCTTCTGATGTTTTAACTGAAAAAGGCAATCTTGAAAGTGTAACATTAAGAGACACTTCTAAAGAATCAGAAACTAGCCCGAAACCGAACATCCATATAGACACCGCTGATCTTGAAAAAAGCTTGGAAGATGAGCTTTTAGAAGAACCGGATGTTAATACTGAAGCAATAAAAAGCCCTGAAATGGGTTTTTCTGCAGAAGAAAGAATGGATCAAAAATTGCTAGAAGAGAAAATACTTGAAGGCTCTGAAATGGACGGTGAAACAGAATTTATAGCTCAGGCCAAAGAGATTATTCACGTGAAAAGTATGAATGAACAAATAAAAAAGACTAAAAAAGAAGATGATTTGACACATATAACTGAAACATTACAAATGGCATCTTCTAATAATGCTGTTTTATCAAAAGATAATCTTTTAGAAGAACCAGATTCTAAGGATGAAACTTCTGAAATTATTACTGTAAAAGACACAGAAAGTTCTGACAAAATTCCTGAAAAGGAATTCCTAACGAACAAAGAATTAGATGAAGATGTTCTGCTAGAAGAAAAGCTCTTAGAAGAACCTGAAAAAGCTGAAGTTATTCCTGATAGTGATGTAACTATGGAAGTTGATGATGAAAATGAAGCAGAGTTACTGAAAGATGATGGAGGTCAAAACGATGGTAGTACTCCTATGGATGTCGATAGTACTGATCCATCTATTGAAAATCAAATGAAGATAGAAGACACGATAACAGATCAGCCAATGGATGTTGAATCCGAAGTAGGAAAGAAAGAGATAGCTCAAACTAATTTAGAAAAGGTTGGTACAAATGAAACAACAGATGAAATCAAAGTAATGATTGAATCTGATGTGCAATTACAAATGACTGAGAAGATCATTCATCAGCCAGTTGAAGAAACAACTAAAACAATAGAGGTTATCAAAGATTTACCTGTTGAAGAAAAACCTGCAACAGTGGAATTTGAAAATAAAGAGACAGCCATTGAAGATCAAGCTAAAATAGACAAGCAAAATATTGATTTAGCTGCGTCAGAGATGGTAAATGTAAATCAACCAATTAATGATGAGAAGAAAATGGTTGAAAACAGTAAAGTTCATTTAATTGTAGAAACTAATACAACAGAAGAGTTTATGGAGACTCCTGAACAATCAGACGCACTCACTGATTCTAATATTGCTAATATTGAAATTCAAGGAAAAGAGAAATCTATTGCAGATAAATCTACACTTGAAAGCAAAGAGGAGCAAGAGCAATCTAAATTAAATACAGAAAGTGTGCATGCAGACATTAATTTTGAAAAACCTGAAAAATCTAAAGAAATTACTGTACTAGACACAAGCTTAGACAAAAACAAAGTTTCTGCTGAGGTTTCACCTAGTTCTTCAATATTTCGAGATAGTCTGTCACCTATCAATAGTTTCCATGGTTTAAATAAACCAGATGTAATGCTAGAAATACCTACTCAAGAATTAATAGACATGGATATGACAGATTTATCTATGAATCTAGACCAATCTGAAGGATTATACAGTAATGACAGAGATGAAAATATAAAAAAAGAGTTGGAAGATGACAACATAATTGATATGTCTATAGCTGAGGATGACACAGTAACTGAGAAATCAGTAGATAATATAACAAAAGTTGTTGATGACACAGCAAACCAAAGCACAGTAGATCAAGACACCATAGTTACTGAAACAAAAGCTAATAAAACTACTGAAAATGACACAGAAAATGAGAAATCAGTAGATCAACAAACCACAGTAACTGAAGCAACAGTAGATAAAGTACCAATGGAGAGCAAAATTGTGAAAAGTGGAAAAAAAGAAGAAACTGTTGTTGAAGCAACTATTGAAGAAACTATGGAAAAACTGTTTGCTGATGTAGAACCGGCGGTTGCTAAAGAAGTTCCTGAGTGCATTGAAAGCAGCAACCAAGTCTCAGCGGAACAATCGGAAGACTCGAATCAAGCAGCCATAGAATCCGAACCAGTCGCAGAGACGGAGGAGAAGGAGTTGGAGACGCCAGGCCCTAAGGAAAGCGAGTTTCCGTTCTTGCGTGATAGTTACTCCCAGGATAAGGGGGAGAAGATCCACATGGAGTATGGGACGATGGAATTACAGGCTGAAACAATAAATGAGATGAATGAAGAGGCAACATCAGCTGTAGCTGCGTTGCTGAATGCTGATAACCCCGTCATTGAAAAACCTAAGTCCCCAAAAGAAACCCCAGAAGAAATGGATATAGAGACAGTGAAACTGTCAGACACGTCTGACAATGAGGCCGACGTTGAACCTACTGTCGTTGAAAAGACTGTGGCTGAACCTAGCAAGGAGGTTGAAGAGGAGCAAAAGAAATCACCATCTAAATCCCCAGTCCAAAGCAATGTATCCCCCAAGGAATCACCAAGCAAGCTGAAGAACTTAGCTATAACCGCGCAAGCGGCTAGATCCGTTGTTAATATTGTGGATTTGGAGGAGAGCAGCTCTTCAGACGATGATATACAAGAAACGGAAGTCCAAAAACAACCGTCACCGGAACCAGAGACAAAAGACGATAAACCTGCATCCCCCGCCCCGGACTCAACAGTTACCAGCGTCAACATACCAACCGGCATAGACATAATACGTAGTGTGTCTTCCGGCGGAGTTACCTCCGAGATTACTACTAAAGATGGAGAGGCTGTTATCAGTGGGGTGCCTAAACCGCCGCCGCATAAGCCTGCCAGATTGAATACGAGTGAAGTTTCCATCAAGACTGTTAGTTCCGCCGAACCAATGGTTATACCTGAAACTAAGATAAGCGAACAGACACCAACACAGTCTAAACCTAAACTGAGTCTAGAAATATTCAGTCTAGATTCTGACGAAGAAGATAGTTCAGCTAAAGAAAAATCTACAACAACTCCGCAACACGAAATGACGGCCTTGGAACTGGAAAAAGCACGAGAAACATCCAAATGTATCAACTACAGTTGCACAAGCGACAACACAGTGCCATACAGGGTTGCGGAGGCAACAGAGGTAGCTTACTACGACGCCAGCAGGAAGAGACGCGCCTTGGTGTGCCAGCCGTGCGCTGCTGTCGTCGCTGAAAGGACTAAGAATCTAATCCAAGGCATGAAGGACCTAACTCCTCTCCTAGAGTTGGACATGCGCAAGTCATCACAGGAACTGGTGGAGATATCAGATTCCGACTCTGAAGACGAGGATATGAATTCTGAGGAGCCGAAGGAGACCATTGGGAAAGAGGGTGCTAAAATCATAGAAGACAGTTTAAGCCAGTTTTTAAACGACACTTGGAAGAAATACAAAATGGACGCGCGGCTCAAAGAGACGCAGATCATGTTAGATGATGAAATCGAGAAACTTGAACAGGACAGCAAAGAAATCGACGCAATGCTGAACGCATGTCAGGTAGCGACGGACAAGCTTCGCTGCGAGTTGTACGCGACATTCGAGTGTCGCCTGCAACAATTACCCCCACTTGTTATACAAGACACGCCTGAGAAAAAATATATTGGACAAGAGGAGCAAGTCATCCCGCCTGTCGTTGGTGAATCAGCAGCGATTCGCCATGCCAAGCGTCGTTTGTCGTCAAGCACCAATGAGTTGCCTGCCAAACGCCCCGCCATACCGCTTGGATATGCTCCTCTAGATTCTGCTGACGCTAAGGAAAAAGCTGCTATTCCTGCACCGGAAAGTAAACTGGATGATGACAAAGACATATCAGTAGTGAAGCTATCAGCGGAAGCGGCCCCGGCCGACCTCCCCCCTCCTGGTGAGATCTCCCGCCCCCCCTTACGAGTGGGGATGCCGGTGTTTGCCATGAAGAACGCCTTCGGACCGTTTCTTAAAGGCAAGGTGCTGGAGATACAACCCAAGAATCCTAGTGGGGGCAACCCATTCTCTCTCTGCCGAGTGAGATTCGACCATAAGGCCAAGAGCAATGGGAAGGTGTTGCAAGCGAGGTCCATCGCTTATTCTGAGCCCGCTGATGTTAGAATGACCATTGGTACTCGTCTCATAGCCTTATTCAAGGATTCGAATAAGCGCGAGTCTTACTACTCGGGCGTGGTCGCTGAAATACCGAACCCGGTGAATAATTATAGATACCTAGTATTCTTCGACGACGGCTACGCTCAATACGTACAGCATCAGTATACCCGCCTAGTCTGCGAGAGCTCCTCTTTAGTATGGGAGGAAGTGCATCCGTTCTCGCGGGAGTTCGTGCGCGAGTACCTGATGGCGTACCCTGAGAGACCCATGGTCAGGTTGCACACGGGGCAGCACCTGAAGACTGAGTGGAACGGAAAATGGTGGGCCTCCCGGGTGACCCGCGTAGACGCATCACTGGCTCAGGTGATGTTCGTGGAGGACGGTCGGCGCGAGTGGATCTACCGCGGTTCAACACGACTCGCACCCTTGTACCTTGAGCTGCGCGCCGCTGAGAGACACCGGCCCCGGCCCATGCCCCGGAGCAAGGCGCAGCCTAGGTTGAATATGCCGTACGTGGAGTACATTCGGTCGGATGAGCAGGAATCCAGCAAGCCTCCAGATGTGCAGGTGCAGGTTCAGCAACAAATGCAACAACAACAGATGCAGCGAGATGAGGAGATTCGTCGCCAACGCGCCGTGGCCAAGAAGTCCACATCAGCACCTCCTCAAGTGTACCCGCCGGCGCATCAGATCATACCGCCCCTCAACACGGATCCTGTCACCAGCAGAGTTGTGTACTACACACCAAAGAATGCAGTCAGACCTTTGAAGATGGTGCCACATAGGTGCACTCCTAAATGCAAGAGAAGCGACGTACTCTCACTAAAGGAGTTGAGGACTTACAACCCGCTGGCCAAACCACTACTTAGCGGATGGGAAAGACAAATAGTCCGCTTCAAGGGCCACAAGGACGTAATGTACCGCGCGCCCTGCGGCCGTCGCATACGCAACATGCGCGAGCTACATCACTACTTACGTTCCATAGACAGCGACCTGCCCGTAGATCTCTTCGATTTCCACTACTCCACGCACTGTCTGGCAGAGTTCGTGTTGAACAAATGTCTTGTCGGGAAAAAGGACCTGTCCCACGGCAAAGAGAACGTGCCGGTGCCGTGCGTGAACTACTACGACGACTCGCTCCCGGAGTTCTGTTCGTACAACACCGAGCGCACACCCACCGCCGGGGTGCCGCTCAACTTGGAGCCCGAGTTCCTGTGCGGCTGCGACTGTACCGATGATTGTCAGGATAAATCAAAATGCGCTTGCTGGAAGATGACGCTAGAGGGCGCTCGGACCATCGGCCTGGTCGGGCCCAATGTGGGCTACGTCTACAAACGATTGCCCGAACCGTTACCCTCTGGAATATATGAGTGTAATTCTAGTCATGACAAGCACCAGAACGGCTATTTAAAGCTTATGTCAACAGAGAAAACAGCCGAGCGGGTTCTTGAACGTTCTATTGGTATAGTGTTCAGAAGCGAGCATGAGGTCCTGGGTTAG
Protein Sequence
MSDKEEKDNKEKEIPRTSQDGGSNNPETLTEGNVLSLNSNKNTENSSTISENKHRSAAIEGSGDNAGRTVQENSELDKIEAELTEMSKELINTDAGIGSGDYTAKAKDSDVDDKIIEDIDTEINAKTSKSDVIAEKDGSNDDLLDKCDDRELKKADDFDEFEDEDMQLRWDEDDDASNQHQGDDNANVGNKNDSILSEDQLLEDSSDVLTEKGNLESVTLRDTSKESETSPKPNIHIDTADLEKSLEDELLEEPDVNTEAIKSPEMGFSAEERMDQKLLEEKILEGSEMDGETEFIAQAKEIIHVKSMNEQIKKTKKEDDLTHITETLQMASSNNAVLSKDNLLEEPDSKDETSEIITVKDTESSDKIPEKEFLTNKELDEDVLLEEKLLEEPEKAEVIPDSDVTMEVDDENEAELLKDDGGQNDGSTPMDVDSTDPSIENQMKIEDTITDQPMDVESEVGKKEIAQTNLEKVGTNETTDEIKVMIESDVQLQMTEKIIHQPVEETTKTIEVIKDLPVEEKPATVEFENKETAIEDQAKIDKQNIDLAASEMVNVNQPINDEKKMVENSKVHLIVETNTTEEFMETPEQSDALTDSNIANIEIQGKEKSIADKSTLESKEEQEQSKLNTESVHADINFEKPEKSKEITVLDTSLDKNKVSAEVSPSSSIFRDSLSPINSFHGLNKPDVMLEIPTQELIDMDMTDLSMNLDQSEGLYSNDRDENIKKELEDDNIIDMSIAEDDTVTEKSVDNITKVVDDTANQSTVDQDTIVTETKANKTTENDTENEKSVDQQTTVTEATVDKVPMESKIVKSGKKEETVVEATIEETMEKLFADVEPAVAKEVPECIESSNQVSAEQSEDSNQAAIESEPVAETEEKELETPGPKESEFPFLRDSYSQDKGEKIHMEYGTMELQAETINEMNEEATSAVAALLNADNPVIEKPKSPKETPEEMDIETVKLSDTSDNEADVEPTVVEKTVAEPSKEVEEEQKKSPSKSPVQSNVSPKESPSKLKNLAITAQAARSVVNIVDLEESSSSDDDIQETEVQKQPSPEPETKDDKPASPAPDSTVTSVNIPTGIDIIRSVSSGGVTSEITTKDGEAVISGVPKPPPHKPARLNTSEVSIKTVSSAEPMVIPETKISEQTPTQSKPKLSLEIFSLDSDEEDSSAKEKSTTTPQHEMTALELEKARETSKCINYSCTSDNTVPYRVAEATEVAYYDASRKRRALVCQPCAAVVAERTKNLIQGMKDLTPLLELDMRKSSQELVEISDSDSEDEDMNSEEPKETIGKEGAKIIEDSLSQFLNDTWKKYKMDARLKETQIMLDDEIEKLEQDSKEIDAMLNACQVATDKLRCELYATFECRLQQLPPLVIQDTPEKKYIGQEEQVIPPVVGESAAIRHAKRRLSSSTNELPAKRPAIPLGYAPLDSADAKEKAAIPAPESKLDDDKDISVVKLSAEAAPADLPPPGEISRPPLRVGMPVFAMKNAFGPFLKGKVLEIQPKNPSGGNPFSLCRVRFDHKAKSNGKVLQARSIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQYTRLVCESSSLVWEEVHPFSREFVREYLMAYPERPMVRLHTGQHLKTEWNGKWWASRVTRVDASLAQVMFVEDGRREWIYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRLNMPYVEYIRSDEQESSKPPDVQVQVQQQMQQQQMQRDEEIRRQRAVAKKSTSAPPQVYPPAHQIIPPLNTDPVTSRVVYYTPKNAVRPLKMVPHRCTPKCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRFKGHKDVMYRAPCGRRIRNMRELHHYLRSIDSDLPVDLFDFHYSTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLVGPNVGYVYKRLPEPLPSGIYECNSSHDKHQNGYLKLMSTEKTAERVLERSIGIVFRSEHEVLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01533075;
90% Identity
-
80% Identity
-