Ntra024439.1
Basic Information
- Insect
- Neocrepidodera transversa
- Gene Symbol
- Runx3
- Assembly
- GCA_963243735.1
- Location
- OY725344.1:11858070-11858510[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 5e-54 4.4e-50 170.1 0.0 2 96 51 145 50 146 0.98
Sequence Information
- Coding Sequence
- ATGTTAGGTGACTGGACATCAAAAACTATGCATCTTACTAACACACCGACTGGTACCACTGGTACGACACCTACACCGGAAGGTACCACGAATTTAATTCAAGAAACTTATACGAAAATGACCAGCGATATATTAGCTGAAAGAAcattaaacgattttttaagtgAACATCCTGGTGAACTAATAAGGACCGGGAGTCCTTTATTTGTTTGTACTGTTCTACCTCCGCATTGGAGGTCGAATAAAACTCTTCCCGTGGCATTTAAGGTAGTGGCATTAGGGGATATTGGTGATGGGACTGTAGTGACTGTTAGAGCCGGTAATGATGAAAATTATTGTGCGGAATTGAGGAACTGTACGGCTGTTATGAAAAATCAAGTAGCTAAATTTAATGATCTTAGGTTTGTTGGCAGAAGTGGAagaggtaagatttttttataa
- Protein Sequence
- MLGDWTSKTMHLTNTPTGTTGTTPTPEGTTNLIQETYTKMTSDILAERTLNDFLSEHPGELIRTGSPLFVCTVLPPHWRSNKTLPVAFKVVALGDIGDGTVVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKIFL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01105349;
- 90% Identity
- iTF_00328931; iTF_00327635; iTF_00248708; iTF_01105349; iTF_00791856; iTF_01226393; iTF_00386961; iTF_00025810; iTF_00458643; iTF_00910297; iTF_01289525; iTF_01310102; iTF_01014028; iTF_00721781; iTF_00735259; iTF_01368798;
- 80% Identity
- -