Msep003850.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mythimna separata
Gene Symbol
PAX1
Assembly
GCA_030763345.1
Location
CM061169.1:22032472-22037452[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 6.9e-69 1e-65 220.3 0.2 3 125 15 137 13 137 0.99

Sequence Information

Coding Sequence
ATGGGCAACCCTGGCGTGGCAGGCACCGGCACCCAGCAGTACGGCGAGGTGAACCAGCTCGGAGGAGTGTTCGTGAACGGCAGGCCGCTGCCCAACGCCGTCAGGCTGCGGATAGTGGAGCTCGCGCAGCTGGGCATCAGGCCTTGTGACATCAGTCGACAGCTGCGGGTGTCGCACGGCTGCGTGTCCAAGATCCTGGCGCGCTACCACGAGACCGGCTCCATCCTGCCCGGAGCCATCGGCGGCTCCAAGCCTAGAGTTACCACACCCAAGGTGGTGTCGTACATAAAGCAGCTGAAGGCGAAGGACCCTGGCATCTTCGCGTGGGAGATCCGCGACCGGCTGCTGGCGGACGGCGTGTGCGACAAGTACAACGTGCCGTCGGTGTCCAGCATCAGCCGCATCCTGCGCAACaagctgggcggcgcgctctacCCCGTGGCGCCGCTCTACCCAGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTATGTGTACTTACAGGGTCGTCAGCACACGGCAGGCAACCCTCACGCACTGCCGCACCCCCACCAGCAGCCGCCTCCCCCCCACCACGCGCACGCGCACGCGCTCTGA
Protein Sequence
MGNPGVAGTGTQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGALYPVAPLYPVPPQRCWPLHQPYDYYVYLQGRQHTAGNPHALPHPHQQPPPPHHAHAHAL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00114915;
90% Identity
iTF_01031115; iTF_00888239; iTF_01029239; iTF_00155265; iTF_00889185; iTF_01491909; iTF_00822984; iTF_01425900; iTF_00908814; iTF_00706927; iTF_01124561; iTF_00441462; iTF_00161514; iTF_00162731; iTF_00820043; iTF_00926575; iTF_00195129; iTF_00636370; iTF_00637621; iTF_00157175; iTF_00406711; iTF_01125435; iTF_00823869; iTF_00869599; iTF_00967999; iTF_00043459; iTF_00300171; iTF_01028259; iTF_01282243; iTF_00787620; iTF_00960132; iTF_00687845; iTF_01362405; iTF_00878822; iTF_01205670; iTF_01202434; iTF_01204007; iTF_01203208; iTF_01204852; iTF_01206519; iTF_00657159; iTF_00818311; iTF_01509575; iTF_00022760; iTF_00290664; iTF_00282313; iTF_00281224; iTF_01071593; iTF_01360585; iTF_01527145; iTF_01340070; iTF_00686314; iTF_01026154; iTF_01082410; iTF_01135722; iTF_01172330; iTF_01312194; iTF_00959371; iTF_01503851; iTF_00171724; iTF_00887372; iTF_00007981; iTF_01072461; iTF_01564621; iTF_00410254; iTF_00680513; iTF_00123343; iTF_00121409; iTF_00255855; iTF_00256884; iTF_00144543; iTF_00289583; iTF_00622799; iTF_01416751; iTF_00021296; iTF_00325345; iTF_00038736; iTF_01230544; iTF_00404881; iTF_01569297; iTF_00772850; iTF_00909682; iTF_00994322; iTF_00007060; iTF_00321556; iTF_00674260; iTF_00704980; iTF_00699137; iTF_00698245; iTF_00701006; iTF_00702863; iTF_00700087; iTF_00697308; iTF_00696446; iTF_00703904; iTF_00148437; iTF_00156213; iTF_01386677; iTF_01387563; iTF_01453237; iTF_01451425; iTF_00667432; iTF_00342166; iTF_00632726; iTF_00723926; iTF_00821782; iTF_00055383; iTF_00411415; iTF_01133699; iTF_01027287; iTF_01487671; iTF_00327049; iTF_01221518; iTF_00186148; iTF_00185279; iTF_00462360; iTF_00001145; iTF_00075481; iTF_00074480; iTF_00355121; iTF_00076501; iTF_01094009; iTF_01208153; iTF_01502939; iTF_00113293; iTF_00114069; iTF_01280245; iTF_00146394; iTF_00187130; iTF_00364894; iTF_00017308; iTF_00834606; iTF_00450085; iTF_01076462; iTF_01251708; iTF_00761649; iTF_01415804; iTF_01443804; iTF_00412477; iTF_00871261; iTF_01197693; iTF_00433118; iTF_00432122; iTF_00433117; iTF_00971199; iTF_00970374; iTF_00658368; iTF_01083296; iTF_01152992; iTF_01561088; iTF_00207882; iTF_00208850; iTF_01542937; iTF_01544847; iTF_01545718; iTF_01546617; iTF_01543904;
80% Identity
iTF_01031115; iTF_00888239; iTF_01029239; iTF_01026154;