Basic Information

Insect: Mythimna lalbum
Gene Symbol: PAX1
Assembly: GCA_949319445.1
Location: OX439363.1:20665990-20672359[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7e-69 1.2e-65 220.1 0.2 3 125 29 151 27 151 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7e-69	1.2e-65	220.1	0.2	3	125	29	151	27	151	0.99

Sequence Information

Coding Sequence: ATGGCTATAGAAAAGAAAGGGAGAGACCCCAGCGGTGGCGGCATGGGCAACCACGGCGTGGCGGGCACCGGCACCCAGCAGTACGGAGAGGTGAACCAGCTCGGAGGAGTGTTCGTGAACGGGAGGCCGCTGCCCAACGCCGTTAGGCTGCGGATAGTCGAGCTGGCGCAGCTGGGGATCAGGCCATGCGACATCAGTCGACAGCTGCGCGTGTCGCACGGCTGCGTGTCCAAGATCCTGGCGCGCTACCACGAGACCGGCTCCATCCTGCCCGGAGCCATCGGGGGCTCCAAGCCTAGAGTTACCACACCCAAGGTGGTGTCCTACATAAAGCAACTAAAAGCGAAGGACCCGGGCATCTTCGCGTGGGAGATCCGGGACCGGCTGCTGGCGGACGGCGTGTGCGACAAGTACAACGTGCCGTCGGTGTCCAGCATCAGCCGCATCCTGCGCAACAAGCTGGGCGGCGCGCTGTACCCCGTGGCGCCGCTGTACCCCGTGCCGCCGCAGCGCTGCTGGCCGCTGCACCAGCCCTACGACTACTACGTCTATTTACAGGGTCGTCAACACACGGCAGGCAACCCCCATGCACTGCCCCACCCCCACCAGCAGCCCCCTCCCCCGCACCACGCGCACGCGCACGCGCTCTGA
Protein Sequence: MAIEKKGRDPSGGGMGNHGVAGTGTQQYGEVNQLGGVFVNGRPLPNAVRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYHETGSILPGAIGGSKPRVTTPKVVSYIKQLKAKDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKLGGALYPVAPLYPVPPQRCWPLHQPYDYYVYLQGRQHTAGNPHALPHPHQQPPPPHHAHAHAL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00889185; iTF_01425034; iTF_01425900; iTF_01124561; iTF_01125435; iTF_00323478; iTF_00406711; iTF_00909682; iTF_01443804; iTF_00824706; iTF_01016642; iTF_01525986; iTF_00186148; iTF_01221518; iTF_00450085; iTF_00687845; iTF_00247156; iTF_01362405; iTF_01506309; iTF_00876134; iTF_00878822; iTF_01202434; iTF_00375175; iTF_00425348; iTF_00686314; iTF_01117183; iTF_01018535; iTF_00042600; iTF_00041745; iTF_00040786; iTF_00039774; iTF_00986024; iTF_00985067; iTF_00959371; iTF_00960132; iTF_00461529; iTF_01034558; iTF_00327049; iTF_01071593; iTF_00205090; iTF_00161514; iTF_00162731; iTF_00207882; iTF_00208850; iTF_01075402; iTF_01157706; iTF_01129992; iTF_01155147; iTF_01337719; iTF_01402681; iTF_01153947; iTF_01156411; iTF_00922845; iTF_01385725; iTF_00667432; iTF_01388437; iTF_00204320; iTF_00840267; iTF_01149556; iTF_00249664; iTF_01161322; iTF_00119567; iTF_01260074; iTF_00737451; iTF_00377075; iTF_00856596; iTF_00638613; iTF_00361592; iTF_00632726; iTF_00356165; iTF_00408425; iTF_01280245; iTF_00146394; iTF_00364894; iTF_01219741; iTF_01503851; iTF_00017308; iTF_00418956; iTF_00419725; iTF_00421304; iTF_00420512; iTF_00049869; iTF_00178125; iTF_00275235; iTF_00682378; iTF_00123343; iTF_00121409; iTF_00783434; iTF_00715759; iTF_00970374; iTF_01062767; iTF_01533903; iTF_00112464; iTF_00428976; iTF_00341287; iTF_01502058; iTF_01429905; iTF_00836531; iTF_00428085; iTF_01358841; iTF_01436059; iTF_00819135; iTF_00859423; iTF_01209232; iTF_01230544; iTF_00685409; iTF_00831169; iTF_01084225; iTF_01285505; iTF_00043459; iTF_00237539; iTF_00273571; iTF_01338724; iTF_01377444; iTF_00147429; iTF_01491909; iTF_00447110; iTF_01340070; iTF_00281224; iTF_01534792; iTF_00282313; iTF_01094889; iTF_01360585; iTF_01527145; iTF_00907018; iTF_00300171; iTF_00784363; iTF_00907851; iTF_01063723; iTF_01166667; iTF_01387563; iTF_00171724; iTF_00794572; iTF_01192684; iTF_01342188; iTF_00834606; iTF_00000303; iTF_00111631; iTF_00622799; iTF_00706927; iTF_01416751; iTF_00038736; iTF_00071408; iTF_01061840; iTF_00172881; iTF_00374065; iTF_00404881; iTF_00761649; iTF_00771889; iTF_00810033; iTF_01531985; iTF_00036658; iTF_01085170; iTF_00758131; iTF_00007060; iTF_00445140; iTF_00711828; iTF_00301141; iTF_01246869; iTF_01386677; iTF_00952694; iTF_00122359; iTF_01064631; iTF_00973752; iTF_01533016; iTF_00037785; iTF_00726329; iTF_01094009; iTF_00906106; iTF_00274396; iTF_00363996; iTF_01251708; iTF_01415804; iTF_00302077; iTF_00124222; iTF_01152126; iTF_00869599; iTF_01083296; iTF_00355121; iTF_01490097; iTF_00835566; iTF_00235828; iTF_00236599; iTF_01569297; iTF_00318066; iTF_00636370; iTF_01439906; iTF_00637621; iTF_00994322; iTF_01507187; iTF_01508033; iTF_00321556; iTF_00635380; iTF_00704980; iTF_00699137; iTF_00698245; iTF_00701006; iTF_00702863; iTF_00772850; iTF_00701939; iTF_00705972; iTF_00148437; iTF_00700087; iTF_00697308; iTF_00696446; iTF_00703904; iTF_01561088; iTF_00663044; iTF_01170568; iTF_01171438; iTF_01529160; iTF_00661250; iTF_00267153; iTF_00662193; iTF_01528256; iTF_01182836; iTF_01542937; iTF_01544847; iTF_01545718; iTF_01546617; iTF_01543904; iTF_01079028; iTF_00446101; iTF_01140885; iTF_01143065; iTF_01148053; iTF_00640290; iTF_00063555; iTF_01010328; iTF_01119303; iTF_01509575; iTF_00198089; iTF_00125098; iTF_00785163; iTF_01076462; iTF_00033775; iTF_00433117; iTF_00433118; iTF_00197330; iTF_00345778; iTF_00634452; iTF_00177078; iTF_00809091; iTF_00928657; iTF_00055383; iTF_00120482; iTF_01312194; iTF_00818311; iTF_01172330; iTF_00432122; iTF_00810999; iTF_00947856; iTF_00018136; iTF_01020248; iTF_00195129; iTF_00187130; iTF_00250427; iTF_01141627; iTF_01148780; iTF_01147350; iTF_00957916; iTF_00012990; iTF_00347446; iTF_00821782; iTF_00925686; iTF_00786756; iTF_01079862; iTF_01080686; iTF_01142358; iTF_01140170; iTF_01145239; iTF_00462360; iTF_01134760; iTF_00156213; iTF_00001145; iTF_00647961; iTF_01437945; iTF_00666505; iTF_00390340; iTF_00895912; iTF_00649065; iTF_00825705; iTF_00913578; iTF_00926575; iTF_00032881; iTF_00206963; iTF_00206037; iTF_01208153; iTF_00649978; iTF_00826940; iTF_00143038; iTF_01438896; iTF_00651716; iTF_01220622; iTF_00951802; iTF_00383623; iTF_00709204; iTF_01538716; iTF_01334810; iTF_00279083; iTF_00006249; iTF_01081558; iTF_00382571; iTF_00695516; iTF_00843500; iTF_00010013; iTF_01464129; iTF_00008951; iTF_01463224; iTF_00823869; iTF_00822984; iTF_00441462; iTF_00157175; iTF_01332601; iTF_00967999; iTF_00185279; iTF_00658368; iTF_00657159; iTF_01072461; iTF_00410254; iTF_00074480; iTF_01453237; iTF_01451425; iTF_01452291; iTF_01281308; iTF_00960896; iTF_00673472; iTF_00159806;
90% Identity: iTF_01030182;
80% Identity: -