Mach022431.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Morpho achilles
Gene Symbol
slp2
Assembly
GCA_947086495.1
Location
CAMTZB010000021.1:17823466-17824167[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.1e-43 6e-40 136.1 0.2 1 87 48 133 48 134 0.96

Sequence Information

Coding Sequence
ATGAGTCCTCCGAGTTTTGCGATCCGAGACTTGTTGCCGGAGGCCTCGTCGCgatccccgtccccctcggacACCGAGCTCGACGTCACGGGCACTGAGACGCCGCCGCCGGGCTCCTCCAGCGCTCCCGAGAAGAAAAACGAGAAACCCGCGTACAGCTACAACGCGCTGATCATGATGGCGATACGCAGCAGCCCTGAAAAGCGGCTCACGCTCAACGGAATCTACGAGTACATCATGAAGAACTTCCCGTACTACAAGGAGAACAAGCAGGGCTGGCAGAATTCGATACGACACAATCTCAGTTTGAACAAGTGCTTCGTGAAAGTGCCGCGGCACTACGACGACCCCGGGAAGGGGAACTACTGGATGCTGGATCCGTCTTCGGACGACGTCTTCATCGGGGGCACGACGGGGAAACTGAGGAGGCGGTCGACCGCGGCGTCCCGGTCCCGTCTGGCTGCCTTCAAAAGGGGCGCGATCCTGCATCCGATGTTCGGGAATCCTTACGCCTCTCTAGTAGGACTGTATCCCCCTCTGTTGTCCGTGTACGGGAGGTACGCTTTGCCCAGCCCGTTGCTGAGGCTGCCGCCGCCCCCCCCTAACCCCTACCACCAGCTGTACCGGCGGCTGCACGGGCTGTCGCCGCCGGTGAGCCCGCCCGACCAGGACCCGGAGCCGCACCTGATGAAGCACAGTTGA
Protein Sequence
MSPPSFAIRDLLPEASSRSPSPSDTELDVTGTETPPPGSSSAPEKKNEKPAYSYNALIMMAIRSSPEKRLTLNGIYEYIMKNFPYYKENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTAASRSRLAAFKRGAILHPMFGNPYASLVGLYPPLLSVYGRYALPSPLLRLPPPPPNPYHQLYRRLHGLSPPVSPPDQDPEPHLMKHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00960740;
90% Identity
iTF_01020994; iTF_00421155; iTF_00419589; iTF_01082242; iTF_00621029; iTF_00778597; iTF_00776583; iTF_00780071; iTF_00774317; iTF_00780845; iTF_01181710; iTF_00782447; iTF_00775859; iTF_00777811; iTF_00457819; iTF_00777244; iTF_00779324; iTF_00775070; iTF_00781630; iTF_00801606; iTF_00959974; iTF_01202278; iTF_00958511; iTF_00959218; iTF_00954215; iTF_00204936; iTF_01151030; iTF_00985800; iTF_00984833; iTF_00695282; iTF_00843306; iTF_00796330; iTF_01077995; iTF_01506145; iTF_01079699; iTF_01080536; iTF_01506972; iTF_00824511; iTF_01507871; iTF_01078880; iTF_01091499; iTF_01360413; iTF_00637282; iTF_01491682; iTF_00822691; iTF_01501891; iTF_00441288; iTF_00908617; iTF_01075177; iTF_00636076; iTF_00794124; iTF_00157005; iTF_00404497; iTF_00909553; iTF_00823730; iTF_01197526; iTF_01435864; iTF_01151866; iTF_00706749; iTF_01166399; iTF_00352844; iTF_00953324; iTF_01438702; iTF_01437772; iTF_01018384; iTF_01152849; iTF_00673298; iTF_00255621; iTF_00256656; iTF_00261651; iTF_00925538; iTF_01178210; iTF_00687717; iTF_00786573; iTF_00144372; iTF_00744411; iTF_00288664; iTF_00467998; iTF_00403572; iTF_01217300; iTF_01247893; iTF_00164128; iTF_00358325; iTF_00357227; iTF_00708981; iTF_00875957; iTF_00875106; iTF_00874257; iTF_00418776; iTF_00710840; iTF_00709993; iTF_00461361; iTF_01561826; iTF_01205509; iTF_01204678; iTF_01203849; iTF_01193418; iTF_01203051; iTF_00878674; iTF_00430423; iTF_00114744; iTF_01206360; iTF_00770910; iTF_00025081; iTF_00287865; iTF_01359522; iTF_00947705; iTF_00405735; iTF_00933530; iTF_00934542; iTF_00353883; iTF_00457052; iTF_00971038; iTF_00970212; iTF_00420351; iTF_00166752;
80% Identity
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