Basic Information

Insect: Mecyna flavalis
Gene Symbol: slp2
Assembly: GCA_949319885.1
Location: OX439434.1:18790236-18790907[-]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.4e-43 5.6e-40 136.3 0.2 1 87 51 136 51 137 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.4e-43	5.6e-40	136.3	0.2	1	87	51	136	51	137	0.96

Sequence Information

Coding Sequence: ATGACTCCTCCGCACAGTTTCGCGATCCGAGACCTGCTGCCCGAGGCGTCCTCGCGCTCGCCCTCGCCGTCGGACACCGAGCTCGACGTAACCGGCACCGAGACCCCGCCGCCCGGCTCCTCCGCGCAGACCGACGAGAAGAAGAAGAACGAGAAACCCGCCTACAGCTACAATGCGCTCATCATGATGGCGATCCGGAGCAGCCCCGAGAAGCGGCTGACACTGAACggtatatacgagtacataatgAAAAACTTTCCGTACTACAAGGAGAATAAGCAGGGCTGGCAGAACTCGATCCGGCACAACCTGAGTCTGAACAAGTGCTTCGTGAAAGTGCCGCGGCACTACGACGACCCCGGGAAGGGGAACTACTGGATGCTGGACCCGTCGTCGGACGACGTGTTCATCGGCGGCACGACGGGCAAGCTGCGGCGGCGGTCGACGGCGGCGTCGCGGTCGCGGCTGGCGGCGTTCAAGCGCGGCGCGCTGCTGCACCCGGCGTGGGGCGGCAGCTACGCGTCGCTGGTGGGGCTGTACCCGCCGCTGCTGTCGGTGTACGCGCGCTGGCCGGCGCCGCTGCTGcgcctgccgccgccgccgccgccctaCCACCAGCTCTACCGGCGCCTGCTGCCGCCCGCCAGCCCGCCGCCCGACGACCACAGCTGA
Protein Sequence: MTPPHSFAIRDLLPEASSRSPSPSDTELDVTGTETPPPGSSAQTDEKKKNEKPAYSYNALIMMAIRSSPEKRLTLNGIYEYIMKNFPYYKENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTAASRSRLAAFKRGALLHPAWGGSYASLVGLYPPLLSVYARWPAPLLRLPPPPPPYHQLYRRLLPPASPPPDDHS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01071445; iTF_01334561; iTF_01148642; iTF_01145108; iTF_01147225; iTF_00124969; iTF_01569069; iTF_01564362; iTF_01081390; iTF_00006097; iTF_00382374; iTF_00284332; iTF_00447971; iTF_00034512; iTF_00035446; iTF_00818955; iTF_00711617; iTF_00859265; iTF_00042434; iTF_00787426; iTF_00925538; iTF_01020994; iTF_01178210; iTF_01359522; iTF_00421155; iTF_00255621; iTF_00419589; iTF_00687717; iTF_00428806; iTF_01358694; iTF_01534598; iTF_00290471; iTF_00405735; iTF_00446920; iTF_01017544; iTF_00194985; iTF_00197929; iTF_00361417; iTF_01533738; iTF_00376907; iTF_00432939; iTF_01091499; iTF_01182475; iTF_01220459; iTF_01425771; iTF_01509387; iTF_00039596; iTF_00300972; iTF_00967852; iTF_01084940; iTF_01312044; iTF_01429740; iTF_00266989; iTF_00786573; iTF_00041582; iTF_00651534; iTF_00928462; iTF_00113935; iTF_00301903; iTF_00256656; iTF_00444912; iTF_00858352; iTF_01018384; iTF_00150289; iTF_00810801; iTF_01152849; iTF_00685234; iTF_00261651; iTF_00144372; iTF_00403572; iTF_00855700; iTF_01061684; iTF_01217300; iTF_01528084; iTF_00040597; iTF_00119413; iTF_00708981; iTF_01064437; iTF_01084053; iTF_01247893; iTF_00043286; iTF_00113142; iTF_00341142; iTF_00632566; iTF_00819862; iTF_00942614; iTF_01335734; iTF_00856407; iTF_01531767; iTF_00063384; iTF_01428856; iTF_00321401; iTF_00445913; iTF_00947705; iTF_00744411; iTF_00355932; iTF_01010172; iTF_01317084; iTF_00427901; iTF_01062557; iTF_01316125; iTF_00686142; iTF_00420351; iTF_01532831; iTF_00164128; iTF_00431936; iTF_01063552; iTF_00008705; iTF_00009810; iTF_01463966; iTF_00342017; iTF_00462177; iTF_01135558; iTF_00155117; iTF_00325174; iTF_00156059; iTF_01134589; iTF_01073409; iTF_00621825; iTF_01542763; iTF_01544686; iTF_01546449; iTF_00345621; iTF_00761430; iTF_01543707; iTF_01331234; iTF_01491682; iTF_00674115; iTF_00806497; iTF_01401086; iTF_00994176; iTF_00186948; iTF_00409092; iTF_00410085; iTF_00412326; iTF_00826628; iTF_00832708; iTF_00076258; iTF_00007813; iTF_01279992; iTF_01281112; iTF_00683130; iTF_00681468; iTF_00836324; iTF_00835353; iTF_00834432; iTF_00642149; iTF_01129861; iTF_01495589; iTF_00913416; iTF_01494125; iTF_01496368; iTF_01494867; iTF_00180254; iTF_01115519; iTF_01503653; iTF_01547333; iTF_00055206; iTF_00278918; iTF_00649830; iTF_00390184; iTF_00648914; iTF_00818164; iTF_00801606; iTF_00985800; iTF_00352844; iTF_01154822; iTF_01156091; iTF_01157472; iTF_00957767; iTF_00827784; iTF_01385512; iTF_01388272; iTF_01387420; iTF_01386526; iTF_01560936; iTF_00772681; iTF_00148290; iTF_00659268; iTF_00680327; iTF_00660114; iTF_00656947; iTF_00658163; iTF_00289430; iTF_00654040; iTF_01133528; iTF_00655898; iTF_00149181; iTF_01072253; iTF_00871102; iTF_00736426; iTF_01180130; iTF_00006888; iTF_01179307; iTF_00640085; iTF_01416576; iTF_00022603; iTF_00720012; iTF_01302094; iTF_00146199; iTF_01245740; iTF_00157005; iTF_01360413; iTF_00275053; iTF_01403248; iTF_01336631; iTF_00177883; iTF_00825389; iTF_00044263; iTF_01500909; iTF_00077294; iTF_01452142; iTF_00206800; iTF_00666312; iTF_00205866; iTF_01142928; iTF_00011746; iTF_01141460; iTF_00072529; iTF_00249521; iTF_00909553; iTF_01161121; iTF_00698982; iTF_00696304; iTF_00704756; iTF_00698075; iTF_00703742; iTF_00705791; iTF_00699904; iTF_00922705; iTF_00142899; iTF_00406515; iTF_00407370; iTF_01016371; iTF_00207668; iTF_00208636; iTF_00795508; iTF_01443636; iTF_00875957; iTF_00875106; iTF_00874257; iTF_01124406; iTF_01125250; iTF_01463062; iTF_00021143; iTF_00751831; iTF_01502776; iTF_00411224; iTF_00418776; iTF_00250265; iTF_00287865; iTF_00837273; iTF_00026650; iTF_00027566; iTF_00277178; iTF_00647802; iTF_00933530; iTF_00934542; iTF_01340954; iTF_00347323; iTF_00353883; iTF_00844123; iTF_01453083; iTF_01451275; iTF_00926396; iTF_01153660; iTF_01158519; iTF_00197181; iTF_00715614; iTF_00790046; iTF_01020030; iTF_01279070; iTF_01282028; iTF_00317919; iTF_00635199; iTF_00634120; iTF_00840127; iTF_01083103; iTF_01251553; iTF_01333535; iTF_00323296; iTF_01090493; iTF_00895723; iTF_00288664; iTF_01207915; iTF_01172135; iTF_01415626; iTF_00364719; iTF_01209009; iTF_00204178; iTF_01436822; iTF_00723774; iTF_00970212; iTF_00971038; iTF_00166752; iTF_00032711; iTF_00074283; iTF_00354893; iTF_01219589; iTF_01529001; iTF_00673298; iTF_00662039; iTF_00025081; iTF_00791003; iTF_00661084; iTF_00161361; iTF_00162311; iTF_00033626; iTF_01487517; iTF_00677345; iTF_00701761; iTF_00851521; iTF_00984833; iTF_01028065; iTF_01506145; iTF_00637282; iTF_00896578; iTF_00907682; iTF_01034338; iTF_01561826; iTF_00012739; iTF_00374979; iTF_00822691; iTF_01501891; iTF_00038500; iTF_00888996; iTF_00120293; iTF_00449925; iTF_00621029; iTF_00778597; iTF_01205509; iTF_01285349; iTF_01526821; iTF_00236454; iTF_00809862; iTF_01092870; iTF_01202278; iTF_01204678; iTF_01246630; iTF_00049703; iTF_00212231; iTF_00247847; iTF_00273415; iTF_00280935; iTF_00776583; iTF_00780071; iTF_00784199; iTF_00954215; iTF_01342023; iTF_01525735; iTF_00124040; iTF_00204936; iTF_00213224; iTF_00441288; iTF_00700808; iTF_00702696; iTF_00726088; iTF_01361384; iTF_00171561; iTF_00326889; iTF_00408201; iTF_00709993; iTF_00908617; iTF_01029961; iTF_01203849; iTF_00036426; iTF_00071210; iTF_00697130; iTF_00796330; iTF_00843306; iTF_00924394; iTF_01193418; iTF_00037579; iTF_00274251; iTF_00357227; iTF_00808907; iTF_01077995; iTF_01119083; iTF_01192427; iTF_01203051; iTF_01230315; iTF_01259883; iTF_01264203; iTF_01337579; iTF_00636076; iTF_00794124; iTF_00951596; iTF_00953324; iTF_01118060; iTF_00111405; iTF_00246989; iTF_00774317; iTF_00780845; iTF_00785005; iTF_00821581; iTF_00906862; iTF_01116974; iTF_01181710; iTF_00122159; iTF_00176911; iTF_00782447; iTF_01094703; iTF_01538543; iTF_00121200; iTF_00299953; iTF_00373713; iTF_00404497; iTF_01093841; iTF_01339761; iTF_01362897; iTF_00123154; iTF_00159634; iTF_00695282; iTF_00823730; iTF_00869426; iTF_00878674; iTF_01221298; iTF_01402546; iTF_01424850; iTF_01439698; iTF_00775859; iTF_00777811; iTF_00888019; iTF_00931027; iTF_01079699; iTF_01338291; iTF_00973524; iTF_00358325; iTF_01173077; iTF_00072054; iTF_00172534; iTF_00237270; iTF_00363830; iTF_00622614; iTF_00745430; iTF_00842454; iTF_01025782; iTF_01033526; iTF_01151030; iTF_01197526; iTF_00185943; iTF_00430423; iTF_00448823; iTF_00757943; iTF_01440791; iTF_00000120; iTF_00114744; iTF_00282072; iTF_00667160; iTF_00710840; iTF_01030936; iTF_01080536; iTF_01206360; iTF_01362296; iTF_01435864; iTF_00425177; iTF_00830969; iTF_00185114; iTF_01151866; iTF_01377274; iTF_01489946; iTF_00000987; iTF_00017147; iTF_00457819; iTF_00952507; iTF_00457052; iTF_00777244; iTF_00779324; iTF_00785820; iTF_00905916; iTF_01332348; iTF_01506972; iTF_00706749; iTF_00722845; iTF_00850397; iTF_01029021; iTF_00017982; iTF_00235678; iTF_00770910; iTF_00771678; iTF_00775070; iTF_00781630; iTF_00783230; iTF_00932222; iTF_00147103; iTF_00824511; iTF_01027103; iTF_01166399; iTF_01507871; iTF_01545567; iTF_00383424; iTF_01078880; iTF_00467998; iTF_00075264; iTF_01147916; iTF_01149383; iTF_01144362; iTF_01437772; iTF_01082242; iTF_01438702; iTF_00276078; iTF_01222288; iTF_01176017; iTF_00638456; iTF_00737277; iTF_00662891; iTF_01099683; iTF_01171268; iTF_01170373; iTF_00959974; iTF_01075177; iTF_00662890; iTF_00958511; iTF_00461361; iTF_00959218; iTF_01142219;
90% Identity: iTF_00284332;
80% Identity: -