Basic Information

Insect: Microplitis deprimator
Gene Symbol: MBD-R2
Assembly: GCA_964016945.1
Location: OZ024712.1:3803482-3820186[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 9.1e-19 6.5e-15 55.5 0.5 9 69 545 605 541 613 0.91

2 2 3.2 2.3e+04 -3.9 0.0 43 58 1167 1182 1165 1190 0.81

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	9.1e-19	6.5e-15	55.5	0.5	9	69	545	605	541	613	0.91
2	2	3.2	2.3e+04	-3.9	0.0	43	58	1167	1182	1165	1190	0.81

Sequence Information

Coding Sequence: ATGGCGCGTAAATGCTGCGTTAAAAATTGTGAAATAAATGGTAGTGATGTGCATGCTGTTGGTATACCGATTCATAGGTTTCCTAAGGATCAACAACTCAAGTGTAAATGGTTAAAAAACGctggttttttaaataattacaaaccACTACCCGGTCAATTTGTTTGCTTCAgacatttttgtaaaaatgattATGAAAAAGTCAACAAAAATACGGCAAATAGTTTGGGACATaaatttttgctgaaaaaagGCTCGGTGCCGACGGTATTTGATAACTATGAGAATCATCCAGATCCCATTGTTCCATTTACAAAGTCAtcagaattaaataattcgacaGAAGATTCAAATCCAGTGAATATTGAAATGATACAAATGGAGAAAGAAAATTCACATAAAACAGAATTATCAAATTCAAAACCAGATGCCGGGAAATCAAAACCAGCTGCCGAAGAAtcaaagaaagaaaaatcgaATAATTTACCTGTTAACTCTGATAATAAATctgaaagtattaaaaaatcaccAAGTTCTGGTAATTTAAGTACAGAGAATACACAGAATGTTGTTGATACTGCAGTAGAAAAGAAAGAATTCACAGAAGATCCTCCAGCGGAACCACCACCTCTTTCAAATGATTCAATTGTTAAATCAGAAATTACcagtaattcaaataataaatctaatggtagcgtagaaaaaaatactccTGTTAAAAAAACATCAGGGGACAATAAAAATGGCAAAAATTCCAAGtctggtaaaaataaaactgctAATAAATTGGGACTAAAATTTTATCCTGGCGCTAAATTGGAAGCtaaagattttaatgaaaaatggtaCGCAGCACGAGTTGTCGAAACAGATTGGGCTGAACGGGAAGTGTTGATACATTTTGATAAATGGAGTTCTAGATATAATGAGTGGATACCAATGGACAGTTCTAGATTAAGAAGCTTTCAAATGCAACCTAgtgaACAAGTGTGGGTGCTACCGGATCAggATACGAAAATGCGTGAATTTGCTGTTGGGGAAAGAATTTTAGCAACGTGGGCAGATGGAAGAAAATATCCAGCCAAAGTAAATGCAGTTTTGGGAGACGATAAATATGATGTTCTTTTTGATGACGGTTATGCTAAAATAGTTCGATCATCGAAAATGACTAAAATTGCGTCCACAAGTTCTAAGaattcaTCAAAAACAATGGAATCAGAATCTTACATTGGTAGTAAACAAGAACGGCGAGATAAAAGTAGAAAACATTCAGTCGTCGATTTATTTTCCCacaaaaaaagaactaaagCAGATGGAGTTGATAAATCATTGAACAAAAAAGATGACAGTGCTGTTGTAAATGATAACAATGAACAATTAAACAATTCCGATAGTGTTAATGACAGTGCTGATGCAACCGGAGGCGAACTCGATGACTCAAGCTCAGAAGTACTACAgggttttgaaaattcaaaacccAAAGTTAGGAATGGCGCGAAAAGAAAACGTGAAGTAGTTAATGATTACGACGATGATACTGGGCCAGAGTGGGTCGATGGTGAACCACAGGGTGTTGAGTCATTTGTTGTCGATGGTAATGAAGGCTCACGTCGTTCAATAATAATACCCGATAAAAAGTTACCACCTGGATGgcaaaaacattttatacagagaaaaACAGGAAGTTCTGCTGGCAAATGGGACGTCGTCTTCTTTCATGAACCgacttgtaaaaaatttcgatcaagaaatgatttaaaagttttctttGAATCCCAACGTCCTCATAATTATGATCCagataaatttgacttttgtATTCATCGCAGAAAAAAGACAATTTCTGCAAAAGCTAAAACAGATGCTGGTGCTAGCGGTAGTAGCAACCCACCAACGACTAATGAagtgccaaaaaaaataaaaacactttTACCTAAAAGTAAAACCGCTACGACAAATGATTTGTTATTGACACCAGTAACTAATAATTACTCTGCTCCAAATCCTGCGCCTGTGGAAGATACTGcAGTTTTTATTGGTGGTCTACGAGTCGAGATGGAAAACAGTGCATACAAATGTCCCAAAGACGGATGTGCCAAAACACTTCGTAACGAAAATCTCTTACAAATGCACATAAAACATTATCATCCAGAGTTCTCAAAATATTTAGGATCAACACCAAATGTTGCTGATTTAGCATACGCGCGTACAATAGGCGAACCAATAATTGATGCAACTccgaaaaaatcaatcaacAATTATACCGATAAACCAACTAGCCGATTTGACAAAAGAAAAACCAACtcagataaattttcatcatcacTGACTCATTCGCTCAGTCAATCTTTTGCAGCATCATCTCCGTTGTCTGTTGCGTCACCAGACACGTCTCAAATTGATAGTCAGTTGAATGGGTTGAAGGATGACATGAAACTTGAATTGATGTCACCGGGTTCAAGTGCTTCTCTGGATATTGATGATGAGTTGACGAAAAAGTCTGACGGTAGCTGTGCAATGTCACCTGGTTCACTGTTCGATTTGAAGTCTAAAGAGGAGAAAACTCAAGCAGGAATAAAAACATTGTTGCCTTTACGACCAGCCAATTCAGTAGACACTACACGAATGGATCGTTCTAAATCCCTTGACGACACTTTTAATTCTGATAGAGGGCAACGGAAACGTCAATTGTCTGAATACAGCTCTGATGCTTCGACCAAAAGTAAAAAACGTCatgGCATACAGGAGCTTACGGATGATTATGGGGATTTAGATGACAGCGCATTGGATACCGAAGGACCTACACCACTTGTCTATAGATTCAGTCGTAGAAAGTCTGACTCTAAGAGCGACGATAACAGCCAGaatggTGACGGtgtaatgatgatgataaatgGTGAAATGATAAAGGTCGAACAATTGAAACgggaagaaataataaattgtactTGTGGTATTGTTGAAGAAGACGGACTTATGATACAATGTGATTTGTGCCTTTGCTGGCAACATGGGCATTGCAATGCTATTGAACGTGAAAAAGATGTAccggaaaaatatatttgttatatttGCCGACATTCGTATCGTCAGAGGCcatcgaaaaaatatatacatgaccAAGACTGGATCAAAGAAGGCAAATTACAaagtttgTCAAAAAGAACAAAGAATCAAGACACTATCAATAAACGAGCGGCGATGCTGAAACGGTCTTATGATTTAGTTGGAGCTCTAATACAGATCCAGCAAATTCTTCATAGTTTGAGAGTCAAGATAAATGTTGCACAaaaCAAAGACCATccgaaattatatttatggGCTAAAAACTGGGAAAAATCCGAATTACCCAAACCAAATGTGGAACCTGTACCAATaatggaaataattaaatccgAGCCAATATTATCGGATACTGATACCGATGTCTGTCAATCAGATATTAAATCAGAGCCAATAGATTCTGATATCAAAGAGGAAATAAATTGCGATAGATCGATACACTCTGATTCAGAATTGATGAAAATTCTTGAAGAAGACAATAATCCTTCTGCTGACGAAccaaaaataaagaaagaacatttaattaaaaatgataaagacgataatttattaacaccAGCAGCAACAAACGGTGACGACAAAATCTCACAAAAAAGTAGTAAAACTGATGGGTCAAAAGTAAAATCTAAAGATggtacagaaaatttaaatagtcaaTCAGGTGAGCCGAGTACCGATAATCAAATGCCATTCGCTACAATAAATGGTGACGATTCTTTGAACGTAAATGATAATGAGCAAGTGATCCAATCATCAAAAGGATTTGAATCAACGTTACAAGACAAACCGGCTGTGCCTCAGCCTTTTATTCCTGAACCAGAAGCTCCAATAGATCCTGATGAATGCCGACTACGTTTGTTGGATCACGTCGatcattttcaaaatcatATTGAAGCTCGGCTAACTGGCATTGAAGCTCAAGTATCTCTTTTAGAAGCCATGGATCCTGATAGTGATTTACCGTTGGATAAAGTTGAACTCCGTGTTAAAGAAACTATGAAAATGTTATTACGTGATCTCAATACTGTAAGAAAACTAGCGTcgttgtgttaa
Protein Sequence: MARKCCVKNCEINGSDVHAVGIPIHRFPKDQQLKCKWLKNAGFLNNYKPLPGQFVCFRHFCKNDYEKVNKNTANSLGHKFLLKKGSVPTVFDNYENHPDPIVPFTKSSELNNSTEDSNPVNIEMIQMEKENSHKTELSNSKPDAGKSKPAAEESKKEKSNNLPVNSDNKSESIKKSPSSGNLSTENTQNVVDTAVEKKEFTEDPPAEPPPLSNDSIVKSEITSNSNNKSNGSVEKNTPVKKTSGDNKNGKNSKSGKNKTANKLGLKFYPGAKLEAKDFNEKWYAARVVETDWAEREVLIHFDKWSSRYNEWIPMDSSRLRSFQMQPSEQVWVLPDQDTKMREFAVGERILATWADGRKYPAKVNAVLGDDKYDVLFDDGYAKIVRSSKMTKIASTSSKNSSKTMESESYIGSKQERRDKSRKHSVVDLFSHKKRTKADGVDKSLNKKDDSAVVNDNNEQLNNSDSVNDSADATGGELDDSSSEVLQGFENSKPKVRNGAKRKREVVNDYDDDTGPEWVDGEPQGVESFVVDGNEGSRRSIIIPDKKLPPGWQKHFIQRKTGSSAGKWDVVFFHEPTCKKFRSRNDLKVFFESQRPHNYDPDKFDFCIHRRKKTISAKAKTDAGASGSSNPPTTNEVPKKIKTLLPKSKTATTNDLLLTPVTNNYSAPNPAPVEDTAVFIGGLRVEMENSAYKCPKDGCAKTLRNENLLQMHIKHYHPEFSKYLGSTPNVADLAYARTIGEPIIDATPKKSINNYTDKPTSRFDKRKTNSDKFSSSLTHSLSQSFAASSPLSVASPDTSQIDSQLNGLKDDMKLELMSPGSSASLDIDDELTKKSDGSCAMSPGSLFDLKSKEEKTQAGIKTLLPLRPANSVDTTRMDRSKSLDDTFNSDRGQRKRQLSEYSSDASTKSKKRHGIQELTDDYGDLDDSALDTEGPTPLVYRFSRRKSDSKSDDNSQNGDGVMMMINGEMIKVEQLKREEIINCTCGIVEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYICYICRHSYRQRPSKKYIHDQDWIKEGKLQSLSKRTKNQDTINKRAAMLKRSYDLVGALIQIQQILHSLRVKINVAQNKDHPKLYLWAKNWEKSELPKPNVEPVPIMEIIKSEPILSDTDTDVCQSDIKSEPIDSDIKEEINCDRSIHSDSELMKILEEDNNPSADEPKIKKEHLIKNDKDDNLLTPAATNGDDKISQKSSKTDGSKVKSKDGTENLNSQSGEPSTDNQMPFATINGDDSLNVNDNEQVIQSSKGFESTLQDKPAVPQPFIPEPEAPIDPDECRLRLLDHVDHFQNHIEARLTGIEAQVSLLEAMDPDSDLPLDKVELRVKETMKMLLRDLNTVRKLASLC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01003524;
90% Identity: iTF_01006137;
80% Identity: iTF_01004309;