Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_000572035.2
Location
NW:907601-925346[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.2e-18 6.3e-15 53.9 0.5 9 69 546 606 542 614 0.91
2 2 2.5 7.1e+03 -3.9 0.0 43 58 1168 1183 1166 1191 0.81

Sequence Information

Coding Sequence
ATGGCGCGTAAATGCTGcgttaaaaattgtgaaataaaTGGTAGTGATGTACATGCTGTTGGTATACCGATTCATAGATTTCCTAAGGATCAACAACTTAAGTGTAAATGGTTAAAAAACGCtggtttttcaaataattacaaacCTCTACCCGGTCAATTTGTTTGCTTCCgacatttttgtaaaaatgattatgaAAAAGTCAACAAAAATACGGCAAATAGTCCTGgacataaatttttgctgaaaaaaGGCTCGGTGCCGACGATATTTGATAACTATGAGAATCATCCAGaTCCCATTATTCCATTTACAAAGTCATCagaattgaataattcgaCAGAAGATTCAAATCCAGTAAATATAGAAATGACACAAATGGAGAAAGAAAATTCACATGAAACAGAATTATCAAATTCAAAACCAGATGCTGAGAAATCGAAACCAGCTTCTGAAGAATCAAAGAAGGAAACATCGAAAAATTTACCCATTAACACAGATAATAAATctgaaagtattaaaaaatcaccACCAAGTTCTGATAATTTAAGTACAGAGAATACACAGAATGTTGTTGATACTGCAGTAGAAAAGAAAGAATTCACAGAAGATCCACCAGCGAAACCGCCACCTCTTTCAAATGACTCGATTGTTAAATCAGAAATTAGCagcaattcaaataataaatctaatggcagcgtagaaaaaaatactgctGTTAAAAAAACATCAGGGGACAATAAAAATGGCAAAAATACCAAGtctggtaaaaataaaaccgctAATAAATTGGGGCTAAAATTCTATCCTGGCGCGAAACTGGAGGCTAaagattttaatgaaaaatgGTACGCAGCACGAGTTGTCGAAACAGATTGGGCTGAACGGGAAGTGTTGATACATTTTGATAAGTGGAGTTCTAGATATAATGAATGGATACCAATGGACAGTTCTAGATTAAGAAGCTTTCAAATGCAACCTAgtgaACAAGTGTGGGTGCTACCGGATCAgGATACAAAAATGCGTGAATTTGCTGTCGGGGAAAGAATTTTAGCAACGTGGGCAGATGGAAGAAAATATCCAGCCAAAGTAAATGCAGTTTTGGGAGACGATAAATATGATGTTCTTTTTGATGACGGTTATGCTAAAATAGTTCGATCATCGAAAATGACTAAAATTGCGTCCACAAGTTCTAAGaattcaTCAAAAACAATGGAATCAGAATCTTACATTGGCAGTAAACAAGAACGGCGAGATAAAAGTAGAAAACACTCAGTCGTCGATTTATTTTCCCacaaaaaaagaactaaagcAGATGGAGTTGATAAATCACTAAACAAAAAAGATGATAGTGTTGTTGTAAATGATAACaatgaacaattaaataattccgaTAGTGTTAATGACAGTGCTGATGCCACTGGTGGCGAACTCGATGACTCTAGCTCGGAAGTACTACAgggttttgaaaattcaaaacccAAAGTTAGGAATGGCGCCAAAAGAAAACGTGAGGTAGTCAATGATTACGACGATGATACTGGGCCAGAGTGGGTCGATGGTGAACCACAGGGTGTTGAATCATTTGCTGTCGATGGTAATGAAGGCTCGCGTCGTTCAATAATAATACCCGATAAAAAGTTACCACCTGGATggcaaaaacattttatacaGAGAAAAACAGGAAGTTCTGCTGGCAAATGGGACGTCGTCTTCTTTCACGAACCgactagtaaaaaatttcgatcaaGAAATGATTTGAAAGTTTTCTTTGAGTCCCAACGTCCTAATAATTATGATCcagataaatttgacttttgtATTCATCgcagaaaaaaaacagtttctGCAAAAGCTAAAACAGATGCGGGTACAAGTGGTAGTAGCAACCCACCAACGACTAATGAAgtgccaaaaaaaataaaaacacttttACCTAAGAGTAAAACCGCTACGACAAATGATTTGTTACTGACACCAGTAACTAATAATTACTCTACGCCTAATCCTGCGCCTGTGGAAGATACTGCAGTTTTTATTGGTGGTCTACGAGTCGAGATGGAAAACAGTGCATACAAATGTCCTAAAGACGGATGTGCCAAAACACTTCGTAATGAAAATCTCTTACAAATGCACATAAAACATTATCACCCAGAGTTCTCAAAGTATTTAGGATCAACACCAAACGTTGCTGATTTAGCGTACGCGCGTACAATAGGCGAACCAATAATTGATGCAACtccgaaaaaatcaatcaacAATTATTCCGATAAACCAACTAGCCGATTTGACAAAAGAAAAACTAActcagataaattttcatcatcacTGAATCATTCGCTCAGTCAATCTTTTGCCGCATCATCTCCGTTGTCTGTTGCGTCACCAGACACGTCTCAAATTGACAGTCAGTTGAACGGGTTGAAGGATGACATGAAACTTGAATTGATGTCACCGGGTTCAAGTGCTTCTCTGGATATTGATGATGAGTTGACCAAAAAGTCTGACGGTAGCTGTGCAATGTCACCTGGTTCACTGTTCGACATGAAGTCTAAAGAGGAAAAAACTCAAGCTGGAATAAAAACATTGTTGCCTTTACGACCTGCTAATTCAGTAGACACTACACGAATGGATCGTTCTAAATCCCTTGATGACACTTTTAATTCTGATAGAGGGCAACGGAAACGTCAATTGTCTGAATACAGCTCTGATGCTTCGACCAAAAGTAAAAAACGACatgGCATACAGGAGCTTACGGATGATTATGGGGATTTAGATGACAGCGCATTGGATACCGAAGGACCTACACCACTTATGTATAGATTCAGTCGTAGAAAGTCTGACTCTAAGAGCGACGATAACAGCCAgaatggTGACGGtgtaatgatgatgataaatggTGAAATGGTAAAGGTCGAACAATTGAAACgggaagaaataataaattgtacttGTGGTATTGTTGAAGAAGACGGACTTATGATACAATGCGATTTGTGCCTTTGCTGGCAACATGGGCATTGTAATGCCATTGAACGGGAAAAAGATGTAccggaaaaatatatttgttatatttgCCGACATCCGTATCGTCAGAGAccatcgaaaaaatatatacatgaccAAGATTGGATCAAAGAAGGCAAATTACAaagtttgTCAAAAAGAACAAAGAATCAAGATACTATTAATAAACGAGCGGCGATGCTGAAACGATCTTACGATTTAGTTGGAGCTCTAATACAGATACAACAAATTCTTCATAGTTTGAGAGTCAAGATAAATGTTGCACAaaaCAAAGACCATccgaaattatatttatgggCTAAAAACTGGGAAAAATCCGAATTGCCCAAACCAAATGTGGAACCAATACCaataatggaaataattaaatccgaGCCAGTATCACCGGATACTGATACCGATGTCTGTCAATCGGACATGAAATCAGAACCAATAGATTCTGATACAAAAGAGGAAATAAATTGCGATAGATCGATACACTCTGATTcagaattaatgaaaattcttGAAGAGGACAATAATCCTTCTGCTGACGaaccaaaaataaagaaagaaaattcaattaaaaataataaagaggataatttattaacaccCACAGCAACAAACGGTGACGACAAAATTCcacaaaaaagtaataaaactgATGGGCCTAAAGTAAAATCAAAAGAtgatacagaaaatttaaatagtcaaTCAGGTGAGCCGAGTACCGATAATCAAATGCCATTCGCTGCAGTAAATGGTGACGATTCTTTGAACGTAAATGACAATGAGCAAGTGATCCAATCATCAAAAGGATTTGAATCAACGTTACAAGACAAACCGGCTATGCCTCAGCCTTTTATTCCTGAACCAGAAGCTCCAATAGATCCTGATGAATGCCGACTACGTTTGTTGGATCACGTCgatcattttcaaaatcatattGAAGCTCGGCTAACTGGCATTGAAGCTCAAGTATCTCTTTTAGAAGCCATGGATCCTGATAGTGATTTACCCTTGGATAAAGTTGAACTCCGTGTTAAAGAAACTATGAAAATGTTATTACGTGATCTCAATACTGTAAGAAAACTAGCCTcgttgtgttaa
Protein Sequence
MARKCCVKNCEINGSDVHAVGIPIHRFPKDQQLKCKWLKNAGFSNNYKPLPGQFVCFRHFCKNDYEKVNKNTANSPGHKFLLKKGSVPTIFDNYENHPDPIIPFTKSSELNNSTEDSNPVNIEMTQMEKENSHETELSNSKPDAEKSKPASEESKKETSKNLPINTDNKSESIKKSPPSSDNLSTENTQNVVDTAVEKKEFTEDPPAKPPPLSNDSIVKSEISSNSNNKSNGSVEKNTAVKKTSGDNKNGKNTKSGKNKTANKLGLKFYPGAKLEAKDFNEKWYAARVVETDWAEREVLIHFDKWSSRYNEWIPMDSSRLRSFQMQPSEQVWVLPDQDTKMREFAVGERILATWADGRKYPAKVNAVLGDDKYDVLFDDGYAKIVRSSKMTKIASTSSKNSSKTMESESYIGSKQERRDKSRKHSVVDLFSHKKRTKADGVDKSLNKKDDSVVVNDNNEQLNNSDSVNDSADATGGELDDSSSEVLQGFENSKPKVRNGAKRKREVVNDYDDDTGPEWVDGEPQGVESFAVDGNEGSRRSIIIPDKKLPPGWQKHFIQRKTGSSAGKWDVVFFHEPTSKKFRSRNDLKVFFESQRPNNYDPDKFDFCIHRRKKTVSAKAKTDAGTSGSSNPPTTNEVPKKIKTLLPKSKTATTNDLLLTPVTNNYSTPNPAPVEDTAVFIGGLRVEMENSAYKCPKDGCAKTLRNENLLQMHIKHYHPEFSKYLGSTPNVADLAYARTIGEPIIDATPKKSINNYSDKPTSRFDKRKTNSDKFSSSLNHSLSQSFAASSPLSVASPDTSQIDSQLNGLKDDMKLELMSPGSSASLDIDDELTKKSDGSCAMSPGSLFDMKSKEEKTQAGIKTLLPLRPANSVDTTRMDRSKSLDDTFNSDRGQRKRQLSEYSSDASTKSKKRHGIQELTDDYGDLDDSALDTEGPTPLMYRFSRRKSDSKSDDNSQNGDGVMMMINGEMVKVEQLKREEIINCTCGIVEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYICYICRHPYRQRPSKKYIHDQDWIKEGKLQSLSKRTKNQDTINKRAAMLKRSYDLVGALIQIQQILHSLRVKINVAQNKDHPKLYLWAKNWEKSELPKPNVEPIPIMEIIKSEPVSPDTDTDVCQSDMKSEPIDSDTKEEINCDRSIHSDSELMKILEEDNNPSADEPKIKKENSIKNNKEDNLLTPTATNGDDKIPQKSNKTDGPKVKSKDDTENLNSQSGEPSTDNQMPFAAVNGDDSLNVNDNEQVIQSSKGFESTLQDKPAMPQPFIPEPEAPIDPDECRLRLLDHVDHFQNHIEARLTGIEAQVSLLEAMDPDSDLPLDKVELRVKETMKMLLRDLNTVRKLASLC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2