Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.081 62 5.6 0.0 26 51 108 133 103 135 0.83

2 7 0.0045 3.4 9.6 0.1 26 52 164 190 158 191 0.88

3 7 0.034 26 6.8 0.0 20 51 186 217 183 219 0.86

4 7 0.091 70 5.5 0.2 22 44 216 238 212 245 0.86

5 7 0.31 2.4e+02 3.7 0.0 26 51 276 301 268 303 0.82

6 7 0.1 77 5.3 0.0 22 44 300 322 297 330 0.85

7 7 0.038 29 6.7 0.1 22 45 328 351 324 358 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.081	62	5.6	0.0	26	51	108	133	103	135	0.83
2	7	0.0045	3.4	9.6	0.1	26	52	164	190	158	191	0.88
3	7	0.034	26	6.8	0.0	20	51	186	217	183	219	0.86
4	7	0.091	70	5.5	0.2	22	44	216	238	212	245	0.86
5	7	0.31	2.4e+02	3.7	0.0	26	51	276	301	268	303	0.82
6	7	0.1	77	5.3	0.0	22	44	300	322	297	330	0.85
7	7	0.038	29	6.7	0.1	22	45	328	351	324	358	0.84

Coding Sequence: ATGGATCCCAAGCTAAAAATTAAGGAAGAAGTATTAAACCATGATTCATATTCACATGATTTGAAATTGGAAATTAAAGAGGAAACTTCTTGTAATGTTGAATGTGACACTATGGTGGAAAATGAAAAGTCTCAGAGGGACATAAATGAATGCAATGACTATGAGAAGGTAAACATCAAACTAGAGATAAAGGAAGAACTACTGGACCCTAGTGCATATTCACTTGAACTGAGATCAAAAACTTTCAAAGAAAGTTTATATAGTGGTGCTCATGACACTGCATTGGAGAATGAGGTAAATATCAGGATTAAAAATTCACCGAAGTGTGAAATCTGTGGGAAGAGCTTTTACAAGGCATCTAATTTGAGACAACATCTTTTAATCCATGAAGGCaagaagccatataaatgtgaagtttgtggtaagagctttaccTATGCTTCTGTCTTGAGGACACACATTTTAATTCATGATGACAAGAAGAGACATAgatgtgaaatttgtgagaagagctttactcagtCATCTAGTTTAAGGAAACATCTTCGTATTCATCAGGGCAAGAAGccccataaatgtgaattttgtggaaaGGACTTTGCCCAAACATCTAATTTGAAacaacatcttttaattcatgaaggtaagaagcctcataaatgtgaagtttgtgagctAAGCTTTACACAGATATCTACTTTGAGGAGACATATTTTGACTCATCAGGGGAAGAAGCTACATAAGTGTGAAGTCTGTGGGTTGAATTTCACGCGGACTTCCAGCTTGAGGAAACATATATTGTCTCATGAGGGTAGAAAGGcccataaatgtgaattttgtagcaagagctttacccagaaatCTAATCTAAAacaacatcttttaattcatgagggcaagaagccacataaatgtgaaatttgtgaacTGAGCTTTACACAAACATCTACTTTGAAGAGACATGCTTTGactcatgagggcaagaagccacacaAGTGTGAAGTTTGCGGGTTGAGCTTTACACAGACATCTACTTTGAGGAGACATGTTTTGACTCATGAGTATAAGAAGTTCCATAACTGA
Protein Sequence: MDPKLKIKEEVLNHDSYSHDLKLEIKEETSCNVECDTMVENEKSQRDINECNDYEKVNIKLEIKEELLDPSAYSLELRSKTFKESLYSGAHDTALENEVNIRIKNSPKCEICGKSFYKASNLRQHLLIHEGKKPYKCEVCGKSFTYASVLRTHILIHDDKKRHRCEICEKSFTQSSSLRKHLRIHQGKKPHKCEFCGKDFAQTSNLKQHLLIHEGKKPHKCEVCELSFTQISTLRRHILTHQGKKLHKCEVCGLNFTRTSSLRKHILSHEGRKAHKCEFCSKSFTQKSNLKQHLLIHEGKKPHKCEICELSFTQTSTLKRHALTHEGKKPHKCEVCGLSFTQTSTLRRHVLTHEYKKFHN

Sequence clustering based on sequence similarity using MMseqs2