Math029390.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mellicta athalia
Gene Symbol
SGF1
Assembly
GCA_905220545.1
Location
HG992195.1:12021163-12022218[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.4e-40 4.6e-37 127.4 0.0 2 88 113 198 112 198 0.98

Sequence Information

Coding Sequence
ATGATCTCGCAGAAGCTGTCGTACGGCGACGTGCCGACGTCCGCGTCGCTATCCTCGCTATCACCGGGCCTCGCGCCACCTTACGTGAATGGAATGGGCTGCATGCCAGCTCAACCTTACCCGAATCTCTACACCAACAACATGGTTGCAAGTGGATCCTGTATGGGCTCGCCGGGCGTCGGATACTCGCCGCCGAGCACGATGGCGTCGTGTATGGGCGGTGGAGGCGCCGTGCCCTACGGTACGCTACCGCGTGAGCAGGAGGCCGCTTCTCCGACATCAGCCTTGCAGCGGGCGCGCAATGACAAGACTTATCGCCGCTCGTACACGCACGCCAAGCCACCGTATTCCTACATATCGCTCATCACCATGGCGATTCAGAACAATCCATCGAGAATGCTGACGCTTTCTGAGATCTATCAGTTCATTATGGACCTATTTCCATTTTATAGACAGAATCAACAACGCTGGCAAAATTCGATAAGGCATTCGCTCTCCTTTAACGATTGTTTCGTCAAAGTACCTAGGACACCTGATAAACCAGGCAAAGGGTCCTTCTGGACATTGCATCCCGATAGTGGAAACATGTTCGAGAACGGCTGTTTCTTGAGACGGCAAAAACGATTCAAGGACGAAAAGAAAGAATCTCTGCGTCAAGCGCAGAAAGCGGCTCAAACGCACGGACACCACGGCGGAGGACACGATAAGCGTGAACATGGTCACGAAAAATCTGGCGGTGGTGGAGCGGGACCTGGAGAAGAAAAGGAGATGCGCGACGAGTTGCTGGCACAGTTGCACGCTGCGCCAGAGTTGTGCCTGCCCGAACACACGCCGTTGGCGCTTGAGCACTATGCTCAGCTGAAACAAGAGCCGACAGGATACGCGCCCGCACCACATCCGTTCAGTATCACTCGGCTGCTGCCCGGCGCTGATACAAAGACAGACCTGAAGATGTACGACGTGAACTACGGATACGGTCACGCGCCCGCCGACAACTACTACCAGTCGCCGCTGTATCACCACCATGCTCACGCACACTCGCAGCCGCCCTTGTGA
Protein Sequence
MISQKLSYGDVPTSASLSSLSPGLAPPYVNGMGCMPAQPYPNLYTNNMVASGSCMGSPGVGYSPPSTMASCMGGGGAVPYGTLPREQEAASPTSALQRARNDKTYRRSYTHAKPPYSYISLITMAIQNNPSRMLTLSEIYQFIMDLFPFYRQNQQRWQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWTLHPDSGNMFENGCFLRRQKRFKDEKKESLRQAQKAAQTHGHHGGGHDKREHGHEKSGGGGAGPGEEKEMRDELLAQLHAAPELCLPEHTPLALEHYAQLKQEPTGYAPAPHPFSITRLLPGADTKTDLKMYDVNYGYGHAPADNYYQSPLYHHHAHAHSQPPL*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01020034; iTF_00420355; iTF_00421159; iTF_00421160; iTF_00419593; iTF_01034342; iTF_00461364; iTF_01033530; iTF_00842459; iTF_00689220; iTF_01148647; iTF_00621033; iTF_01140041; iTF_00801610; iTF_00954220; iTF_01091503; iTF_00780075; iTF_00775073; iTF_00180258; iTF_00781634; iTF_00777251; iTF_01115523; iTF_00011751; iTF_00012744; iTF_01495592; iTF_00778601; iTF_00960745; iTF_01129865; iTF_00959978; iTF_00776587; iTF_00194989; iTF_00709998; iTF_00953328; iTF_01220464; iTF_00720017; iTF_00780849; iTF_01494129; iTF_00774322; iTF_01181714; iTF_00782451; iTF_00958515; iTF_01302099; iTF_00249525; iTF_01176021; iTF_00072534; iTF_00651542; iTF_00855702; iTF_00959222; iTF_01402550; iTF_01496374; iTF_00775863; iTF_00777815; iTF_01494871; iTF_00144376; iTF_00640090; iTF_00146203; iTF_00457056; iTF_00779328; iTF_00197185; iTF_00844129; iTF_01500914; iTF_01336635; iTF_00177887; iTF_01386529; iTF_01385515; iTF_01388276; iTF_01387423; iTF_00722850; iTF_00247852; iTF_00246994; iTF_00159639; iTF_01279074; iTF_00075268; iTF_00076262; iTF_00074288; iTF_01282033; iTF_01281116; iTF_01463971; iTF_00164132; iTF_00323300; iTF_00008710; iTF_00896582; iTF_00925543; iTF_00832712; iTF_00647807; iTF_01547338; iTF_00405739; iTF_00649835; iTF_00827788; iTF_00706753; iTF_01072257; iTF_00659272; iTF_00822696; iTF_01501896; iTF_01264208; iTF_00157010; iTF_00660118; iTF_00823734; iTF_00656951; iTF_00658167; iTF_00931032; iTF_00708985; iTF_00289434; iTF_01197531; iTF_00654044; iTF_00655903; iTF_00022605; iTF_01075181; iTF_00843310; iTF_01415631; iTF_01564367; iTF_01337584; iTF_00352849; iTF_00786577; iTF_01078001; iTF_00275058; iTF_00354898; iTF_00077299; iTF_01569075; iTF_01018389; iTF_01017549; iTF_00009815; iTF_00403576; iTF_00406520; iTF_00407374; iTF_01463066; iTF_00751835; iTF_01151035; iTF_01279996; iTF_00321405; iTF_00347325; iTF_00408206; iTF_00364723; iTF_01071449; iTF_00942618; iTF_01435869; iTF_00837278; iTF_00834437; iTF_01340959; iTF_00353888; iTF_00212236; iTF_00213229; iTF_00197934; iTF_01029966; iTF_00836328; iTF_01029025; iTF_01028070; iTF_00808912; iTF_00888024; iTF_01440796; iTF_00835357; iTF_01030941; iTF_00785824; iTF_01140751; iTF_01147919; iTF_00261654; iTF_00687721; iTF_00744415; iTF_01178214; iTF_00934546; iTF_01217304; iTF_01247896; iTF_00288667; iTF_00933534; iTF_00874262; iTF_00875110; iTF_00875962; iTF_01138774; iTF_01139460; iTF_01149386; iTF_01144366; iTF_01142223; iTF_01142930; iTF_01141465; iTF_01147227; iTF_00796333; iTF_00909557; iTF_00698079; iTF_00696308; iTF_01079704; iTF_01078885; iTF_01145112; iTF_00358330; iTF_00357231; iTF_01193423; iTF_00430428; iTF_01205513; iTF_01202282; iTF_01204683; iTF_01203853; iTF_01203055; iTF_00878678; iTF_01206364; iTF_01133531; iTF_00409096; iTF_00410089; iTF_00114749; iTF_00770915; iTF_01154827; iTF_00840130; iTF_00255625; iTF_00642153; iTF_00922708; iTF_00256661; iTF_00204182; iTF_01158523; iTF_01156095; iTF_00287869; iTF_01359526; iTF_00673302; iTF_01152854; iTF_00025085; iTF_00710844; iTF_00277183; iTF_01080541; iTF_00457824;
90% Identity
iTF_00791009;
80% Identity
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