Mrot000443.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Megachile rotundata
Gene Symbol
Foxk1
Assembly
GCA_000220905.1
Location
NW:907698-911501[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.7e-41 2.5e-38 129.3 0.3 1 86 360 444 360 446 0.97

Sequence Information

Coding Sequence
atgtcTTTCTCGTTAATGGTATTATCGATGATATTGACCGATATCAATCCATGGCCTGGGTCGGATACTAGAATTTTGACTCGTCATTCTTACTCCTGTCCTATTCGTACAAACAGTGTTTCTTTCTCCGGCGGTAACTCACTCGTTCTCTATCCGCCATCCGCGTCTATGTATCTAGTTATCTGTTCGGTTATCTGTCTATCTATATCTATCTGTCTGCTTgtcctttttctctctctcatTCTATCCCGAAGGAGGGTTTGCTCACTCGGTGCTATGTCTACGTACTCCCGTACTCAGGAGAGCGACGCGTGGGCCCTTCTGGCACTCAAGTCGGCACCGGCCAGTCCGACGAAGATGCAGTGGAACCCGGAGGCAAAGGGTGCACCGATTGCACGACTGGAGGGTCGCGAGTTTGAATACATGGTTAGACAGCGACGTATCACTATCGGACGTAACAGCAGCAGGGGTGAGGTCGACGTCAACATGGGCCACTCCAGCTTTATCTCGCGACGGCACCTTGAAATCTTTTATGATCACCCTTTTTTCTTTATGATTTGCAACGGTAAAAATGGAGTTTTCGTTGATGGAGTCTTTCAACGAAAAGGCGCGCCTGCCTTTCAATTACCAAAGACATGCACATTCAGATTTCCAAGTACAAATATAAGACTGGTATTTCAGTCATTAGTAGATGAACAGGAGCAAAATAATGTACGCCTACCTTCTCCGCCGAAACATAGGGCACCATTGCCACCTTTACGTATCAATATTCCTGATACAGGATATAGCAGTCCGTTTCCTTCTCCTACTGGAACTATCAGTGCAGCCAATTCTTGTCCTGCTAGTCCACGTGCAGGTCAGGGAAGGAGAAACATATCGGCAGACCTTCAAATGGTGGCAGTGTATGCAGCTGCTGTTGCCAACGATCCGCAAAATTCAAACATGGAAAGACACGACGGAGGACAAAGTTCTAGCAGACAGATAAGCCCTGAACTTGGGGTAGAATCAAGATATAGGGGTGGAAGCAGTTCCGGACCAAATGGCACGACAGCAAATTGTAGTCCTCCAAAGGATGACTCTAAACCACCATATTCGTATGCGCAGCTAATTGTTCAGGCAATAGCATCTGCTACGGACAAACAGCTCACTTTATCCGGCATTTATTCTTACATTACCAAGAATTACCCATATTATAGAACCGCAGATAAGGGTTGGCAAAATTCTATAAGGCATAATCTTTCGTTGAATCGCTATTTTATCAAAGTACCAAGAAGTCAAGAAGAACCAGGAAAAGGATCTTTCTGGAGAATAGATCCTCAATCGGAAGCAAAACTCATAGAACAAGCTTTTAGAAGAAGAAGACAGCGTGGAGTGCCTTGTTTTCGAGCTCCTTTCGGTCTCTCGTCCAGGAGTGCACCCGCTTCGCCGTCTCACGTAGGAATTAGTGGGTTAATGACACCGGAATGCCTCAGTAGAGAAACGTCGCCGGGCCCAGAATCTTACCCGGATAGTTCCGTACCTTCTCCGGCTGGTCAGTTGACTAGTCAGTCCGCACCAGGATCACCCGGTCATCCATACGCGCCTTCGAATCAATCGTCTCATAAGGGTCGTCTAATGCAACAGATTACCGTCGTTACGAACGGTGTTACGAGTGATACAGCTAGAGAAGATAAGTACGTGGTATCCGGGAACGTGACAGAAGAACATTCTCTTTCACCGGCCGGTCAGTACAGTCCGGCTCCTGTTATCGTACAAACGACGTACAACTACAGCGGAAGCTTTATTGGTCCCGACGCAGGCGTCGGAGTTGCAAAGCGTTCGCACGAGGAATCGGATAGTTCTCCTGGTTCACCAGCCCCGCTCGCTATCGTCGAAAGTCCCGAGCCATCCGAGCACCAACAACCACAGACGAAACGTCAACGCGTTCACGATATGGACGATCATTGA
Protein Sequence
MSFSLMVLSMILTDINPWPGSDTRILTRHSYSCPIRTNSVSFSGGNSLVLYPPSASMYLVICSVICLSISICLLVLFLSLILSRRRVCSLGAMSTYSRTQESDAWALLALKSAPASPTKMQWNPEAKGAPIARLEGREFEYMVRQRRITIGRNSSRGEVDVNMGHSSFISRRHLEIFYDHPFFFMICNGKNGVFVDGVFQRKGAPAFQLPKTCTFRFPSTNIRLVFQSLVDEQEQNNVRLPSPPKHRAPLPPLRINIPDTGYSSPFPSPTGTISAANSCPASPRAGQGRRNISADLQMVAVYAAAVANDPQNSNMERHDGGQSSSRQISPELGVESRYRGGSSSGPNGTTANCSPPKDDSKPPYSYAQLIVQAIASATDKQLTLSGIYSYITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPQSEAKLIEQAFRRRRQRGVPCFRAPFGLSSRSAPASPSHVGISGLMTPECLSRETSPGPESYPDSSVPSPAGQLTSQSAPGSPGHPYAPSNQSSHKGRLMQQITVVTNGVTSDTAREDKYVVSGNVTEEHSLSPAGQYSPAPVIVQTTYNYSGSFIGPDAGVGVAKRSHEESDSSPGSPAPLAIVESPEPSEHQQPQTKRQRVHDMDDH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00798380;
90% Identity
iTF_00295809; iTF_00773601; iTF_00183107; iTF_00295043; iTF_00964291; iTF_00254884; iTF_00297348; iTF_00961637; iTF_00965861; iTF_00292742; iTF_01198470; iTF_01512007; iTF_00254120; iTF_01199208; iTF_00291337; iTF_00683977; iTF_00252618; iTF_01089802; iTF_00962315; iTF_00088589; iTF_00684621; iTF_01233453; iTF_01512653; iTF_01070862; iTF_01417518; iTF_00293519; iTF_01234159; iTF_01234831; iTF_01514641; iTF_00084338; iTF_00183762; iTF_01255346; iTF_01394930; iTF_01498002; iTF_01537650; iTF_01475251; iTF_01539411; iTF_01472980; iTF_01513972; iTF_01424181; iTF_00085974; iTF_00962998; iTF_01130614; iTF_00675832; iTF_01473720; iTF_00087738; iTF_00391099; iTF_00086908; iTF_00251869; iTF_00292093; iTF_00298109; iTF_00633437; iTF_00296574; iTF_00294271; iTF_00770176; iTF_00861698; iTF_00024450; iTF_00860195; iTF_00864451; iTF_00763050; iTF_00862378; iTF_00860939; iTF_00865134; iTF_00863087; iTF_00866520; iTF_00863770; iTF_00762365; iTF_00865822; iTF_00085092; iTF_01418820; iTF_01420747; iTF_00873618; iTF_01418174; iTF_01419456; iTF_01453892; iTF_01232229; iTF_01420105; iTF_01122891; iTF_01122240; iTF_00141647; iTF_00140396; iTF_00142291; iTF_00141072; iTF_00982099; iTF_01232819; iTF_01513280; iTF_00117812; iTF_00756436; iTF_01168980; iTF_01474486; iTF_00253367; iTF_00982775; iTF_00360025; iTF_00360718; iTF_00625310; iTF_00733792;
80% Identity
iTF_00964291;