Basic Information

Insect: Heteropelma amictum
Gene Symbol: Foxk1
Assembly: GCA_959613375.1
Location: OY390725.1:6237617-6242477[+]

Transcription Factor Domain

TF Family: Fork_head
Domain: Fork_head domain
PFAM: PF00250
TF Group: Helix-turn-helix
Description: The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.7e-41 2.4e-38 130.2 0.3 1 86 271 355 271 357 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.7e-41	2.4e-38	130.2	0.3	1	86	271	355	271	357	0.97

Sequence Information

Coding Sequence: ATGTCTACGTATTCGAGAACACAAGAGAGCGACGCGTGGGCTCTGTTGGCTCTCAAATCGGCACCGGCTAGCCCGACAAAGATGCAATGGAATCCCGAATCAAAGGGTGCACCTATTGCCCGTCTCGAGGGTCGTGAATTCGAGTACATGGTTAGACAGAGAAGAATTACAATCGGTCGTAACAGTAGCAAGGGCGAGGTTGACGTAAATATGGGACACTCGAGTTTTATATCGCGACGGCatctcgaaatattttacGATCATCCGTATTTCTTCATGACTTGCAATGGAAAAAATGGTGTTTTCGTTGATGGAGTTTTTCAACGCAAAGGGGCACCAGCATTTCAACTGCCAAAGACGTGTACATTCAGATTTCCGAGTACGAACATAAGGCTGGTGTTTCAATCGCTGGTCGACGAACAGGAGCAGTCGAGCAGCGTTAGGATGGCGTCTCCTCCAAAGCAGAGAGCACCCTTGCCACCGCTGAGAATAAATATACCGGACACGGGGTACAGCAGTCCATTTCCATCGCCAACGGGAACGATAAGCGCGGCAAACTCGTGTCCGGCGAGTCCGCGCGCGGGACAAAGCCGGCGGAATATTTCGGCTGATTTACAAATGGTCGCGGCGTACGCGGCGGCCGTCGCCCACGATCCGCAAAATTCCGGCATCGAGAGAACCGACGGCGGACAAAGTTCGAGTCGACAAATGAGTCCGGAGCCCGGTATCGAGTCGCGTTATCGCGGTAGCGGCGGTGGTACAAGCGGCGCTAACGGTACCGCGGCTCATTACAGCCCACCAAAGGACGACTCGAAACCACCGTATTCTTACGCCCAGTTGATAGTTCAAGCTATCGCTTCGGCCCAGGATAAACAGCTGACCCTGTCGGGAATTTACTCCtatataacgaaaaattatccGTACTACAGAACCGCCGACAAGGGTTGGCAAAATTCCATAAGACACAATTTGTCGTTAAATCGTTATTTTATAAAAGTACCGAGGAGCCAAGAAGAACCGGGCAAAGGATCATTCTGGAGGATAGATCCGCAATCCGAGGCTAAATTAATCGAGCAGGCTTTCAGAAGGAGAAGGCAGCGCGGTGTTCCTTGCTTCCGTGCGCCGTTTGGATTATCCTCGAGAAGCGCACCTGCATCGCCGTCGCACGTGGGGATAAGTGGCTTGATGACGCCCGAGTGTCTCAGCAGAGAAGGCTCACCAGGAACGGAATCTTACGTCGACAGTTCCGTGCCTTCACCAGCCGGACAGTTGTCGAGTCAGTCAGCACCGGGTTCACCCGGTCATCCTTACGCTCCACCGCCCCCACCACCCACTCACAAGGGACGTCTGATGCAACAGATCACGGTTGTGACCAACGGCGTGAGCGGTGACGCAACGAGAGAAGAAAAATACTTGGTGCCTGGAAACGTCGTAGAGGAACACTCGTTATCTCCCGCTGGGCAATACAGTCCGGCTCCTGTTATTGTACAAACGACTTATAATTACagTGGAAGCTTCATTGGCCCTGACGCTGGCGTCGGGGTGAACAAACGGGCTCACGAAGAGCCCGATAGTTCGCCAGGCTCGCCGGCGCCTCTCGCTATCGTCGAGAGTCCCGAACCACCGGAGCACCAGCAACAAAAACGTCAACGTATTCACGACGCTGACGATCATTGA
Protein Sequence: MSTYSRTQESDAWALLALKSAPASPTKMQWNPESKGAPIARLEGREFEYMVRQRRITIGRNSSKGEVDVNMGHSSFISRRHLEIFYDHPYFFMTCNGKNGVFVDGVFQRKGAPAFQLPKTCTFRFPSTNIRLVFQSLVDEQEQSSSVRMASPPKQRAPLPPLRINIPDTGYSSPFPSPTGTISAANSCPASPRAGQSRRNISADLQMVAAYAAAVAHDPQNSGIERTDGGQSSSRQMSPEPGIESRYRGSGGGTSGANGTAAHYSPPKDDSKPPYSYAQLIVQAIASAQDKQLTLSGIYSYITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRIDPQSEAKLIEQAFRRRRQRGVPCFRAPFGLSSRSAPASPSHVGISGLMTPECLSREGSPGTESYVDSSVPSPAGQLSSQSAPGSPGHPYAPPPPPPTHKGRLMQQITVVTNGVSGDATREEKYLVPGNVVEEHSLSPAGQYSPAPVIVQTTYNYSGSFIGPDAGVGVNKRAHEEPDSSPGSPAPLAIVESPEPPEHQQQKRQRIHDADDH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00713505; iTF_00714184; iTF_01381134; iTF_01380419; iTF_00712659; iTF_00738881; iTF_00937825; iTF_01077281; iTF_01254608; iTF_00279778; iTF_00868578; iTF_01269603; iTF_00867204; iTF_00181126; iTF_00109639; iTF_01270312; iTF_00867948; iTF_01355117; iTF_00280462; iTF_00729102; iTF_01268078; iTF_00730543; iTF_01266703; iTF_00182450; iTF_00264083; iTF_00181783; iTF_01268823; iTF_01267355; iTF_01354429; iTF_01066050; iTF_01066754; iTF_01068784; iTF_01065361; iTF_01069458; iTF_01070165; iTF_01067418; iTF_01068092; iTF_00718341; iTF_00719197; iTF_00880263; iTF_00879428; iTF_00881808; iTF_00882761; iTF_00881042; iTF_01523175; iTF_01004873; iTF_01003339; iTF_01005822; iTF_01004031; iTF_00379439; iTF_01379017; iTF_00652487; iTF_00342952; iTF_01497192; iTF_01306223; iTF_01207153; iTF_00414106; iTF_00262466; iTF_01057442; iTF_00439268; iTF_00828581; iTF_00829289; iTF_01100394; iTF_00628913; iTF_01129146; iTF_00266258; iTF_00265476; iTF_01298962; iTF_01467764; iTF_01513972; iTF_01232229; iTF_01514641; iTF_01513280; iTF_00263191; iTF_00050616; iTF_01508667; iTF_00459548; iTF_01055775; iTF_01056597; iTF_00377802; iTF_00378532; iTF_00380107; iTF_00380881; iTF_00381652; iTF_01113227; iTF_01111564; iTF_01110733; iTF_01109913; iTF_01112386; iTF_00452396; iTF_00905222; iTF_00059252; iTF_01364437; iTF_00058487; iTF_00057728; iTF_00721056; iTF_01087023; iTF_00397080; iTF_00397865; iTF_00840858; iTF_00010895; iTF_00089345; iTF_00200554; iTF_00064247; iTF_00983440; iTF_00117812; iTF_00733792; iTF_01489204; iTF_00016502; iTF_01560246; iTF_01000353; iTF_01001063; iTF_00996842; iTF_00996143; iTF_00451739; iTF_00417368; iTF_01048056; iTF_01048705; iTF_00877658; iTF_01475994; iTF_00963675; iTF_00295809; iTF_00773601; iTF_00183107; iTF_00295043; iTF_00964291; iTF_00254884; iTF_00297348; iTF_00961637; iTF_00965861; iTF_00292742; iTF_01198470; iTF_01512007; iTF_00254120; iTF_01199208; iTF_00291337; iTF_00683977; iTF_00252618; iTF_01089802; iTF_00962315; iTF_01122891; iTF_00140396; iTF_00088589; iTF_00684621; iTF_01233453; iTF_01512653; iTF_00360718; iTF_01070862; iTF_01417518; iTF_00141647; iTF_00293519; iTF_01234159; iTF_01234831; iTF_00084338; iTF_00183762; iTF_01255346; iTF_01394930; iTF_01498002; iTF_01537650; iTF_00982099; iTF_01232819; iTF_01475251; iTF_01539411; iTF_01168980; iTF_01472980; iTF_01424181; iTF_00085974; iTF_00962998; iTF_01130614; iTF_00982775; iTF_00675832; iTF_01473720; iTF_00360025; iTF_00087738; iTF_00391099; iTF_00086908; iTF_00251869; iTF_00292093; iTF_00298109; iTF_00633437; iTF_00296574; iTF_00294271; iTF_00770176; iTF_01122240; iTF_00438561; iTF_00437890; iTF_01273602; iTF_00046765; iTF_01272909; iTF_00045944; iTF_00350811; iTF_00047776; iTF_00024450; iTF_00861698; iTF_00860195; iTF_00864451; iTF_00763050; iTF_00862378; iTF_00860939; iTF_00865134; iTF_00863087; iTF_00866520; iTF_00863770; iTF_00762365; iTF_00865822; iTF_00939330; iTF_00938474; iTF_01413963; iTF_01303116; iTF_01412914; iTF_00059987; iTF_01412115; iTF_01411285; iTF_00158908; iTF_00079619; iTF_00128771; iTF_00126508; iTF_00125716; iTF_00127253; iTF_00127992; iTF_00129534; iTF_00168195; iTF_00668227; iTF_01001891; iTF_01476739; iTF_00085092; iTF_01407972; iTF_01418820; iTF_01420105; iTF_01420747; iTF_00873618; iTF_01418174; iTF_01419456; iTF_01453892; iTF_01520036; iTF_00143685; iTF_00223685; iTF_00224370; iTF_00218229; iTF_00223001; iTF_00014534; iTF_01261674; iTF_00015859; iTF_00015197; iTF_00214215; iTF_00226404; iTF_00216198; iTF_00220393; iTF_00218922; iTF_00222346; iTF_00229163; iTF_00232427; iTF_00221068; iTF_00221740; iTF_00227086; iTF_00229840; iTF_00233042; iTF_00214835; iTF_00216884; iTF_00230517; iTF_00225720; iTF_00231128; iTF_00227770; iTF_00225051; iTF_00231803; iTF_00217564; iTF_00219612; iTF_00215517; iTF_00460295; iTF_01245031; iTF_00898568; iTF_01394088; iTF_00692713; iTF_01422729; iTF_01423449; iTF_01422042; iTF_01036011; iTF_01036830; iTF_01199948; iTF_01379820; iTF_01390892; iTF_01274285; iTF_00306062; iTF_01035247; iTF_00175568; iTF_00264817; iTF_00729870; iTF_01488337; iTF_01391762; iTF_00142291; iTF_00141072; iTF_01190131; iTF_00690900; iTF_00756436; iTF_00173973; iTF_00174831; iTF_01390005; iTF_01393302; iTF_01389229; iTF_01474486; iTF_00073527; iTF_00253367; iTF_00286999; iTF_00676503; iTF_01405495; iTF_01103352; iTF_01428088; iTF_01099001; iTF_00968603; iTF_00969381; iTF_01271003; iTF_01392571; iTF_01407035; iTF_00286140; iTF_00317276; iTF_00316579; iTF_00385084; iTF_00728476; iTF_01120028; iTF_00228477; iTF_00625310; iTF_00884862; iTF_00765347; iTF_00393407; iTF_00691743; iTF_00769439; iTF_01015615; iTF_01228831; iTF_01228200; iTF_01406303; iTF_01408864; iTF_00302846; iTF_01468638; iTF_01464847; iTF_01469467; iTF_00326175; iTF_00734375; iTF_01466911; iTF_01465990;
90% Identity: iTF_00939330;
80% Identity: -