Basic Information

Gene Symbol
e2f4
Assembly
GCA_902806685.1
Location
NC:13047680-13053933[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.2e-29 2e-25 87.8 0.3 2 65 11 75 10 75 0.98
2 2 0.83 2.6e+03 -2.3 0.0 12 36 174 198 172 199 0.75

Sequence Information

Coding Sequence
ATGACGGAATTATACTGTTATAAACGATATGAGAAATCGTTGGGGCTACTTACTACGAGATTTGTGTCACTTCTTCAAAAAGCAAAGGATGGTGTTTTGGATTTAAAAGTCGCCACCGACTTACTAGCTGTTAGGCAGAAACGAAGAATATATGATATAACGAATGTTTTAGAAGGAATTGGACTTATTGAGAAACGTAGTAAAAACAGTATACAATGGAAAGGAGCGGCTCCCGATTCTAATACATCAGATATTGGCGTGAAGGTGATCCAATtaagaaaagaaataaatttGTTGGAAGAACACGAGCAATTATTAGATAAGCAAATGCATTGGATAGAACAAagtattaaaaatgttattgaTGACACAGACAATGAGGCTTTGACTTATgtaacagaaaatgatattaaGGAATGCTTTGACGATGAtcaaatttttgttttggaaGCCCCTCTTGGAGCTGATTTGGCTGTTGGACGTGTACCTAGCAATGAGCCAGGAAaagatcataatttttttttacatgtaAAATCAAACAATCCCATTGGAGTCATATTATTGTCTGATGTGGAAAAAGAAATGGTAACAGAGGATGAAAACATGGACCAAGAAGTGCAAAGTTACACTGATGCTGCTGACGATAATGTATTGCAATACCCTAATTACCTTGTAAGATTAAGTCCACCTGCTAGCAAGCAAGACTTTTCTTTTTCATTGCGTGGATCGGAAGGTTTATGCGATCTCTTTGATATTCCTTGTTAA
Protein Sequence
MTELYCYKRYEKSLGLLTTRFVSLLQKAKDGVLDLKVATDLLAVRQKRRIYDITNVLEGIGLIEKRSKNSIQWKGAAPDSNTSDIGVKVIQLRKEINLLEEHEQLLDKQMHWIEQSIKNVIDDTDNEALTYVTENDIKECFDDDQIFVLEAPLGADLAVGRVPSNEPGKDHNFFLHVKSNNPIGVILLSDVEKEMVTEDENMDQEVQSYTDAADDNVLQYPNYLVRLSPPASKQDFSFSLRGSEGLCDLFDIPC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00801596;
90% Identity
iTF_00954203;
80% Identity
-