Mbra010259.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Mamestra brassicae
Gene Symbol
slp2
Assembly
GCA_905163435.1
Location
LR990995.1:19785756-19786724[+]

Transcription Factor Domain

TF Family
Fork_head
Domain
Fork_head domain
PFAM
PF00250
TF Group
Helix-turn-helix
Description
The fork head domain is a conserved DNA-binding domain (also known as a winged helix) of about 100 amino-acid residues. Drosophila melanogaster fork head protein is a transcription factor that promotes terminal rather than segmental development, contains neither homeodomains nor zinc-fingers characteristic of other transcription factors [1]. Instead, it contains a distinct type of DNA-binding region, containing around 100 amino acids, which has since been identified in a number of transcription factors (including D. melanogaster FD1-5, mammalian HNF-3, human HTLF, Saccharomyces cerevisiae HCM1, etc.). This is referred to as the fork head domain but is also known as a 'winged helix' [1, 2, 3]. The fork head domain binds B-DNA as a monomer [2], but shows no similarity to previously identified DNA-binding motifs. Although the domain is found in several different transcription factors, a common function is their involvement in early developmental decisions of cell fates during embryogenesis [3].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.3e-42 4e-39 133.3 0.1 1 87 68 153 68 154 0.97

Sequence Information

Coding Sequence
ATGGTGAAGTTCGAAGGAGATTTCAGTATTAATTCTATACTGATGAACAAACCCGCTCCCCCGCCATCCCCCACGGCCTCGTCGACGGGCGCCTCGCCCTCCGAGGCCGACCTCAGCGACTCCGAGCTGGACGTCACGGGCACCGAGCCCGTCGACTGCACGAAACCCAAAGATGACGACGACAAGAAGGACAAGAAGCACGAGAAACCCGCATACAGCTACAATGCCCTCATCATGATGGCCATCCGCAACAGCCCCGAGAAGCGGCTCACATTGAACGGCATCTACGAATACATCATGACAAACTTCCCGTACTACAGAGAGAACAGGCAAGGCTGGCAGAACTCCATCCGCCACAACCTGAGTTTGAACAAGTGCTTTGTGAAAGTGCCGCGCCACTACGACGACCCCGGCAAGGGCAACTACTGGATGCTGGACGCATCGGCCGAGGATGTTTTCATCGGCGGCACCACGGGCAAGCTGCGACGCCGCTCCGCGCTCAACGGCCGCTCGCGCTTGGCGTGTTTCAAGCGGCCGCTGTTCCCCGGCGCCGCGCTGCCCGGAGCCTACCCACCCGCCACCTACTCACAGCTCGTGGGCCTGTACTCGCAGCTCTTGTATCAAAGGTACGCGCCGATGCAAATGAAGACTCCTCCCGTGGCGCCCAGCGCCGTGCACCCCGCCTTCCGCGGCGACGCCATGGGCTACGGCAGCCTGCCGTACTCGCCGGCGCTCTACGACCGCTTGCCGTCGGGCCCCTTCCTCGGGCAGTCGCCGCTGCTGCAGGGCTCGCAGCTGGCGCAGCAGTCTGCGATGCTGGCGCAGACGTCGCCGCTGCTGCCCGCGTCGCCGCCCATGCTGCACTCGCCGCCGCACTCGGGCGCGTCCAGCCCCGAGCTGCCGTCGCCGTCGCACCACCCGCTCACGCCTCACATCTACAAGCCGGTCACGGTGCTCACGCGACAGTGA
Protein Sequence
MVKFEGDFSINSILMNKPAPPPSPTASSTGASPSEADLSDSELDVTGTEPVDCTKPKDDDDKKDKKHEKPAYSYNALIMMAIRNSPEKRLTLNGIYEYIMTNFPYYRENRQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDASAEDVFIGGTTGKLRRRSALNGRSRLACFKRPLFPGAALPGAYPPATYSQLVGLYSQLLYQRYAPMQMKTPPVAPSAVHPAFRGDAMGYGSLPYSPALYDRLPSGPFLGQSPLLQGSQLAQQSAMLAQTSPLLPASPPMLHSPPHSGASSPELPSPSHHPLTPHIYKPVTVLTRQ*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00790047;
90% Identity
iTF_00383425; iTF_00621826; iTF_01073410; iTF_01180131; iTF_01179308; iTF_01439699; iTF_00761431; iTF_00677346; iTF_01501892; iTF_00449926; iTF_01534599; iTF_00928463; iTF_01532832; iTF_00273416; iTF_00784200; iTF_01285350; iTF_00785006; iTF_00785821; iTF_00783231; iTF_00726089; iTF_01361385; iTF_01029962; iTF_01075178; iTF_00171563; iTF_01538544; iTF_01119084; iTF_01118061; iTF_00111406; iTF_01116975; iTF_01028066; iTF_00374980; iTF_00038501; iTF_01525736; iTF_01526822; iTF_00036427; iTF_00924395; iTF_00037580; iTF_00274252; iTF_00851522; iTF_00363831; iTF_00830970; iTF_01230316; iTF_01025783; iTF_00809863; iTF_00808908; iTF_00973525; iTF_01030937; iTF_01029022; iTF_01027104; iTF_00794125; iTF_00967853; iTF_01084941; iTF_01063553; iTF_00711618; iTF_00685235; iTF_01061685; iTF_01064438; iTF_01084054; iTF_01062558; iTF_00821582; iTF_01332349; iTF_00041583; iTF_00176912; iTF_00299954; iTF_01339762; iTF_01362898; iTF_00404499; iTF_00404498; iTF_00888020; iTF_01338292; iTF_00040598; iTF_00042435; iTF_00043287; iTF_00039597; iTF_00072055; iTF_00745431; iTF_00282073; iTF_00280936; iTF_01362297; iTF_00425178; iTF_00172535; iTF_01092871; iTF_00124041; iTF_00122160; iTF_01094704; iTF_00121201; iTF_01093842; iTF_00667161; iTF_00373714; iTF_00622615; iTF_00448824; iTF_01440792; iTF_00123155; iTF_01377275; iTF_00000988; iTF_01259884; iTF_00000121; iTF_00905917; iTF_00706750; iTF_00850398; iTF_01360414; iTF_00822692; iTF_00441289; iTF_00823731; iTF_01197527; iTF_00017983; iTF_00932223; iTF_00931028; iTF_00708982; iTF_00147104; iTF_01424851;
80% Identity
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