Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.023 2.4e+02 3.1 0.2 19 52 12 45 4 46 0.82

2 7 0.001 11 7.4 0.0 22 49 43 70 39 73 0.86

3 7 0.0068 73 4.8 0.0 21 51 70 100 68 101 0.87

4 7 0.0005 5.3 8.5 0.1 21 46 98 123 96 131 0.89

5 7 0.00099 11 7.5 0.0 21 52 130 161 125 163 0.88

6 7 0.0015 16 6.9 0.0 21 51 158 188 156 189 0.87

7 7 0.00042 4.4 8.7 0.3 21 46 186 211 183 216 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.023	2.4e+02	3.1	0.2	19	52	12	45	4	46	0.82
2	7	0.001	11	7.4	0.0	22	49	43	70	39	73	0.86
3	7	0.0068	73	4.8	0.0	21	51	70	100	68	101	0.87
4	7	0.0005	5.3	8.5	0.1	21	46	98	123	96	131	0.89
5	7	0.00099	11	7.5	0.0	21	52	130	161	125	163	0.88
6	7	0.0015	16	6.9	0.0	21	51	158	188	156	189	0.87
7	7	0.00042	4.4	8.7	0.3	21	46	186	211	183	216	0.90

Coding Sequence: ATGGAAATGTCAGAAATACCGGAAGTGAAGGTGTCCAGCTGCAGTAAACCATTTCAGTGTTCGGAGTGTAACAAACAGTTCCGGCAGTTGAGCACATTGACAAATCATATGAAAATACACACTGGTGATAAACCCTACAAATGCACAATATGCTCGAAAGAATTTCGCCAAACCACAACCCTGTCCAATCATATAAAAATTCACACAGGAGAAAAACCTTTTCACTGCACCTACTGCGGTAAACAGTTCCGTCAATTGAGTACGCTATCCAACCATCTCAAAATCCATACCGGAGAAAAACCCTACGAATGCTCAGTCTGTGGGAAACAGTTTCGGCAGAGCAGTACCCTGAACAGTCACATCCGGATTCACTCGGATGACAAGTACTCTGTGAAACCCTTCAAATGCAGCGTTTGCCCCAAGGAGTTCCGCCAAACTACGACCCTATCAAACCACCTGAAAATTCACACCGGTGAAAAACCTTACTTATGTAcatattgcaataaaagttttaGACAGACAGGCACGCTCTCGAACCACTTAAAAATTCATACCGGAGAAAAACCTTACGAATGTTCTGTGTGCCGAAAACAGTTTCGACAGTCCAGTACGCTGAATTCTCACATTCGAATCCACGCGGAGGACAAGATATGTAAAACATCTCCATCACCACTTCCGTCAACTGTGACCACAATCACCATGAAGCTGGAAGATATGAAACCGCCGCTGTACACCATCATTTAG
Protein Sequence: MEMSEIPEVKVSSCSKPFQCSECNKQFRQLSTLTNHMKIHTGDKPYKCTICSKEFRQTTTLSNHIKIHTGEKPFHCTYCGKQFRQLSTLSNHLKIHTGEKPYECSVCGKQFRQSSTLNSHIRIHSDDKYSVKPFKCSVCPKEFRQTTTLSNHLKIHTGEKPYLCTYCNKSFRQTGTLSNHLKIHTGEKPYECSVCRKQFRQSSTLNSHIRIHAEDKICKTSPSPLPSTVTTITMKLEDMKPPLYTII

Sequence clustering based on sequence similarity using MMseqs2