Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 0.022 1.3e+02 3.2 0.1 23 47 11 35 4 39 0.84

2 8 0.00067 3.9 8.0 0.1 22 47 41 66 36 71 0.87

3 8 0.015 89 3.7 0.4 22 47 72 97 66 101 0.85

4 8 0.027 1.5e+02 2.9 0.1 23 47 103 127 99 132 0.80

5 8 0.024 1.4e+02 3.0 0.1 23 47 134 158 129 161 0.83

6 8 0.00067 3.9 8.0 0.1 22 47 164 189 158 193 0.87

7 8 0.024 1.4e+02 3.1 0.1 23 47 196 220 190 222 0.83

8 8 0.00067 3.9 8.0 0.1 22 47 226 251 220 255 0.87

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	0.022	1.3e+02	3.2	0.1	23	47	11	35	4	39	0.84
2	8	0.00067	3.9	8.0	0.1	22	47	41	66	36	71	0.87
3	8	0.015	89	3.7	0.4	22	47	72	97	66	101	0.85
4	8	0.027	1.5e+02	2.9	0.1	23	47	103	127	99	132	0.80
5	8	0.024	1.4e+02	3.0	0.1	23	47	134	158	129	161	0.83
6	8	0.00067	3.9	8.0	0.1	22	47	164	189	158	193	0.87
7	8	0.024	1.4e+02	3.1	0.1	23	47	196	220	190	222	0.83
8	8	0.00067	3.9	8.0	0.1	22	47	226	251	220	255	0.87

Coding Sequence: atgaaattgcatgatgagACTAGGGAGAAGCAGAAATACCAGTGTCAACATTGTGAGAATACCTTTGCGTATGCATGGAATCTCAAACGGcacatgaaattgcatgatgagACTAGTGAGAAGCAGAAAAACCAGTGTCCAcattgtgagaaaacctttgcgTATGCATGGAATCTCAAACGGCACATGCAATTGCATGATGAGACTAGGGAGAAGCAGAAATACCAGTGTCAACATTGTGAGAATACCTTTGCGTATGCAAGGACTCTCAAACGGcacatgaaattgcatgatgagACTAGGGAGAAGAAAAACCAGTGTCAAcattgtgagaaaacctttgcgTATGCATGGAATCTCAAACGGCACATGCAATTGCATGATGAGACTAGGGAGAAGCAGAAATACCAGTGTCAACATTGTGAGAATACCTTTGCGTATGCATGGAATCTCAAACGGcacatgaaattgcatgatgagACTAGTGAGAAGCAGAAAAACCAGTGTCCAcattgtgagaaaacctttgcgTATGCATGGAATCTCAAACGGCACATGCAATTGCATGATGAGACTAGGGAGAAGCAGAAATACCAGTGTCAACATTGTGAGAATACCTTTGCGTATGCATGGAATCTCAAACGGcacatgaaattgcatgatgagACTAGTGAGAAGCAGAAAAACCAGTGTCCAcattgtgagaaaacctttgcgTATGCATGGAATCTCAAACGGCACATGCAATTGCATGATGAGACTAGGGAGAAGCAGAAATACCAGTGTCAACATTGTGAGAATACCTTTGCGTTCACATCACAAAATCAGATAGCTGATCATATGCTAAGCCATAACGATAGCGGCGATGTTGACAATGCAGCTCTCGCCATTTCCTCCTCAGACGATCTCGCCATTTTAACGAGATATAATCTGAAAACTTATCAggacaccagcagcagcagcagtgatAGTGATGACAATGACGCGGAGGTAGTGGATAAGGCGGGGATTGTCCAACAAAGCTTGCGTAATGGTGCAATGCAGAAGGATATTTAG
Protein Sequence: MKLHDETREKQKYQCQHCENTFAYAWNLKRHMKLHDETSEKQKNQCPHCEKTFAYAWNLKRHMQLHDETREKQKYQCQHCENTFAYARTLKRHMKLHDETREKKNQCQHCEKTFAYAWNLKRHMQLHDETREKQKYQCQHCENTFAYAWNLKRHMKLHDETSEKQKNQCPHCEKTFAYAWNLKRHMQLHDETREKQKYQCQHCENTFAYAWNLKRHMKLHDETSEKQKNQCPHCEKTFAYAWNLKRHMQLHDETREKQKYQCQHCENTFAFTSQNQIADHMLSHNDSGDVDNAALAISSSDDLAILTRYNLKTYQDTSSSSSDSDDNDAEVVDKAGIVQQSLRNGAMQKDI

Sequence clustering based on sequence similarity using MMseqs2