Basic Information

Gene Symbol
egg_1
Assembly
GCA_947363905.1
Location
OX376213.1:6859560-6903014[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4 1.2e+04 -3.6 0.1 28 38 1940 1969 1929 1970 0.61
2 2 1.2e-12 3.8e-09 36.5 0.0 4 73 2001 2063 1998 2067 0.88

Sequence Information

Coding Sequence
ATGCCTCAGTTAGCAGCTATAGACGGGTCTGGAGGTGACAAAAATCGCATTCTACAAGATAACATAAAACTTGATAAATTAGAAGCAGAGTTGACAGAAACGTCAATAGAATTCATAAATACTAAAGCAGGCGAAGGTTCTAGTGACTATACAGCCAAAGCAAAGGTCAGTAGAATAGATGACAAAGAAATTGAGGATGTTAACACTGAAATTGATGCAATAATATCTAAAACGAATGTTACTGCTGAGAAAGATGAAAGCGATGAAAAATGTGATGAAATAGAATCTAAGACTGCTGATGATCCTGACGAGATTGAAGATGAAGATATGGAACTAAGATGGGATGACGATGATGCTAGCAACCAGGCTATGGGTGATGATATCAGAAATGCAGATGCTAAGAATGAAGATATTCTAACTGAAGACCAACTTTTGGAAGACACTTCGGATCTTTTAACTAAAGATATGACTGAGATGCCTTCTGATGGTGATCCCAAAGTTTCTGAAGCCAATCTTGATAGTCTTACTAGAGACAATAATTTCAAAGAAATTGAAACTACTAAAGACTCTGAAATTAGTCCAAAACTGGACATTCCTACAGATAAGGCTGAAGATGAGCTTTTAGGGGAAAACAACTTAAATACTGAAGCAATAAATAGCCCAGAAATGGACTTTCCCACAGAGGGAAGTATGGGTCGAGATGACGAAAAAAGCTTGGGGGATGAGCTTTCAGGGGAGAACAACTTAAATACTGAAGCAATAAATAGCCCAGAAATGGACTTTCCCGCAGAAGGAAGTATGGATCGAGATGACGAAAAAAGCTTGGGGGATGAGCTTTTAGGGGAAAACAACTTAAATACTGAAGCAATAAATAGCCCAGATATGGACTTTCCCGCAGAAGGAAGTATGGATCGAGATTACGAAAAAAGCTTGGGAGATGAGCTTTTAGGGGAAAACGACTTAAATACTGAAGCAATAAATAGCCCAGATATGGACTTTCCCGCAGAACAAAGTATGGATAGAGATGACATCAATGTTTTAGAGGAAAAATTATTGGAAGAATCTGAAATTGTCACTGAAGCAGCAGTAATAGCTCAAGCAAATGAGATTCTTGAAGAGAAAAGTATAGATGAACCAATAAAAGAGACAGAATCTGTAAAAGACAATCTTCTAAAAGAGGTTACTACTGATGAACAGACAAAAGAAAATCCAGTTGACATTATTGAAGATGAACTTTTAGCTGAAACTGAAAGTAATACTGAAACGGAGTCTTCAACATTGAAGTTGAAATCTTTTACAGATGTCATCTTAATCAAAGACAATGATGATATAATGTCAGAAGAAAACCTTTTAAAAGAACCTGATCCGAAGGGCGAAAGTTCTTTGATTATATCTGAGAAAGACATTGAATTTTCTAAAACTGTTCCTGAAAAACAAGCTCCTGTGAATAAAGAAGATAATGATGATGTTCTGCTAGAAGAAAAACTGTTACAAGAAACGGAAACAGCAGAAGTTATTCCTGAAAGTGATGTAACAATGGATGTTGATGATGAGGAAGAAGGAGAGTTACTGAAAGATGATGAATGTCAAGAAGATAGTTGTACTCCTATGGATGTTGACAATACTGATACATCTATTGACGATCAAGCTAAGATAGAAGATAAGATTATAAATCAAACAGTGAATCAATCTGAAGTGGCTAAGAAAGATATAGCTTTCCCAATAGATGACCAAACTAATATAGAAAAGGTAGATGAAACAAAAGATGAAGTTGAAAATATGGATCAATCTGATGATCAGAGTAAAATTATTGAGGAAGATATTGATCAGCCAATTAAAGATACAACTAAAGCAGTAGATATTACTAAAGATACTCCTATTGAAGATGAACCTAGTATCAATGAGAAAATTGTAGATCAAGGTATAACTGAAAAAGAGACAATTGATGAACAAATTGATGTTCAAACTAAAATGGGAGCCAGCAATAAGGATCCATTAATTCTAGAATCTGATACAAAAGAGCAGTCTATTAAAAGTCCTGAACAAATAGCATCACTCACTGTTTGTAATACTCCTAATATTCTTGTTGAAGATCTAAAGAAAACTACTCCTGAAAAAGAAATTAAAAATAAAACAGATCCAGAAGAACCTACAGCAGATACTGAGAATATTAACAAAAACATTGATTTAGACAAACCTGAAAAAAGTAAAGAAACTATCAATCCTGAAACTAGCTTAGATAAAAATGAAGACGTTGATAAAATTTCAGCGAACAACTCATCAATATTTCTAGAAGATTCATGTCCTATCAAAACTGACCACGGCTTACATAGACCGGATGTGATGTTAGAAATACCTACACAAGAATTGATTGACATGGATGATACAGATTTGTCTATGAATTTAGACCATTCTGAAATGCTTGACAGTCTTAATTATGTTGACAAAAATGCTGAAGACGACATAGTACATGAAAAAACAATTGATAAAAGTGTAATTGATGATGTCATAGTAAGTGATGACATTGTCACTGATGGCGCGGCAGTCAGTGAGAAATCAGTAGATAACACTATAGCTGATGATGACACAGTAAAACAGAAACCAGTAGATCAAAAAGCCATAGCTACTGAAACAACAGCTGTTGATAAAAACGTCACTGATGATGACACAGTAAAAGAGAAATCGTTAGTTCAAGAAGCAATAGTGACTGAATCAACAGTAGGTGAAGTCCAAACAGAAAGTAATATTGTGGAAAGTGACAGGAAAGATGATGATGCACTTGTTCAATCAACAGTTGAAGAAAACATGGAAAAAATGTTTGCTGATGATGAGCCGGGAGTCGCTAAAGAAATTGCAGAGTGCATTGCATCCACAAGCCAAGCTCAAGTTCCCACCCAACATCCATCAACATCCATAACCCGTATGACTCCAGACACATCGGATGAGGTTCCAGAGATTGATGACAGTCTGGGACTGTTGGCTGAGTCTGCAGGACGGATGATGGAGGATGATGAGGAGCCGGATGATGATTTTGATGGTGATGATGATGACGATTTTGATCAAGATGAAAGCAGCAACCAAATCTCAGCCGAACAGTCGGAAGACTCGAACCCAGCAGCCCTAGAGTCTGAACCAGTAAGAGACCAGGAGGACAAGGAATTGGAGACTCCAGACCCTAAGGATGAAGAGTTTCCGTTCATGATGTGTGACAGTACCTCCCAGGATAAGGCGGAGAAGATGGACGTGGAAGAGGAATATGGGACGGTGCAATTAGAAGCAGAAACAGTTAATGAGATGAATGAAGAGGCAAAGTCGGCAGTTGATGCGTTGTTGAACGCTGACAACCCCGCCGATGAACAAGCCGAGAATCAACAAGAAACCACGGATCAGATGGACATAGAGACGGTGAAACTGTCAGATACGTCTGACAATGAGGTTGATGTTGAACCTACAAAGGTTCAAACAACTGTGGCTGTATCAAGCAAAGAGAGTGAAGAAAAACAAAAGTCATCACCATCTAAATCGCCGAACAAGAGCAATATATCGCCAAAGCAATCGCCGAGTAAGTTAAGCCAGTCACCCAGTAAAAAATCACCAAGCAAGATGAAGAATTTGGCTATCACCACGCAAGAAGCTAGCTCGGTTGTCAACATTGTGGATTTAGAGGAGAGCAGCTCTTCTGAAGATGACATACAAGAAGTACAAAAACAACCAGAGACAACAGTGGACGATAAATCTCCTTCCCCGGAATCAGCTGTTACCAACGTTAACATACCAACGGGCATAGACATAATGTGTACTTCCGGCGGAAATACGTCCGAGATAACGACTAAAGACAACCGCTCCCAGGTTGTTATCAGTGGCGTTCCGAAGCCGCCGCCGCATAAACCTGCCAGATTGAACACCAGTGAAGTTACAATCAAAACTGCTAGTAACACCGAACCATTGATTATTCCTGAAACTAAGATTAATGAACAGAATCAGACACAGGCGAAACCGAAACTGAGTCTAGAAATATTCAGTCTGGATTCTGACGACGATGAAAGTGCAGCTAAAGAAAAAGCAACTCCGACTTCCCCCGACAAAATGACAGCCTTGGAACTAGATAAAGCCCGAGAAACATCCAAATGTATAAACTATTGTTGCACAAGCGACAGCAAAGTGCCTTACAAGGTGGCGGAGGCGTCAGTGATCGCGTACTACGACGCGGGCCGGAAGAGACGCTCCGTGGTGTGCCAGCCATGCGCCGATGTGGTCACTGCAAGGACTAAGAATCTAATTCAAGGCATAAAAGAACTAACCCCTCTCCTTGACCTGGACATGGGCAAGTTGTCACAAGACCTGGTGGAGATATCTGACTCGGAGTCTGAAGATGAAGAAATGAGTCCTGAGGAACCCAAGGAGAGTATCGGAGAGAAGGGGGCGAAATTCATAGAAGACAATCTAGCCAAGTTTTTGAACGATACTTGGAAAAAATACGACATGGACTTGCGGCTTACAGAGACACAGCTCATGTTAGATGACGAGATTGAAAAGCTTGAAAAGGACAGCAAAGAAATAGACGCAATGCTAAACGAGTGTCAGGTAGCGACGGACAAGCTTCGCTGCGAGTTATACGCGACGTTCGAGTGTCGCCGACAACAACAGCCCTCCCTAGTAATATGCGACACACCTGACTCTAAATATATCGGACTAGAAGAGAAAATAAATCCTCCTGCTGTAGCCGAATCAATTATTGAGACTCGTCAAGCTAAACGTCGGTTGTCGTCAACCAGTGAGACGCCAGCCAAACGTCCTGCCATACCTCTTGGATATGCTCCTTTAGATGCCGGCGACGCTAAGGAGAAAGCAGCTATTCCCGGACCTGATATAAAATTAGATGACGACAAAGACATATCAGTAGTGAAGCTCTCAGCGGAGGCTGCCCCGGCCGACCTGCCTCCCCCTGGAGAGATCTCCCGCCCCCCCCTGCGCGTGGGCATGCCGGTCTACGCCATGAAGAACGCCTTCGGACCCTGGCTTAAAGGCAGGGTGGTGGAGATACAGCCAAAAAATACCAGTGGGGGCAACCCATTCTCTCTCTGTCTTGTGAAATTCGACCATAAAGTGAAGACTAATGGGAAAGTATTGCCAGCAAGGTGCATCGCGTATTCTGAGCCTGCAGATGTCAGAATGACTATTGGTACTCGTCTAATAGCTCTGTTCAAGGATTCGAACAAGCGTGAATCGTACTACTCAGGTGTTGTCGCTGAAATACCCAATCCAGTCAATAATTATAGATACCTAGTATTCTTCGACGACGGATACGCTCAGTACGTCCAACATCAATTCACCCGCCTTGTGTGCGAAAGCTCCCCCTTAGTATGGGAGGAAGTACATCCGTTCTCGCGGGAATTCGTCCGAGAATACCTGCTGGCGTATCCTGAGAGACCTATGGTCAGGCTGCATGAGGGACAGCATCTGAAGACTGAGTGGAACGGAAAATGGTGGTCGTCCCGCGTGACCCGCGTGGACGCGTCGCTGGCGCAGGTGATGTTCGTGGGCGACGGGCGGCGCGAGTGGGTGTACCGCGGCTCCACGCGCCTCGCGCCGCTCTACCTCGAGCTGCGCGCCGCCGAGCGACACCGGCCCCGCCCCATGCCGCGCAGCAAGGCGCAGCCACGGTTCAATATGCCGTACGTAGAGTACACTCGGTCGGATGAGCAGGAATCGAGCAAGCAAGTGGATGCGCAGGCGCAGCAACAACAACAGCAGCAGCAACAGTTGCAAAATGAGGAGATACGTCGCCAACGCTCCGTGGCCAAGAAGTCTACCTCAGCCCCTCCCCAAGTGCTCCCGCCGTCACAACAGGTCATGCCGCCCGCACACATGGACCCTGTCACCAGCAGAGTTGTGTATTACACGCCAAAGAACGCGGTGAAACCATTGAAGATGGTGCCACACAGATGCGGTGCGAGATGCAAGCGAAGCGACGTACTGTCACTAAAGGAGTTGAGAACTTATAACCCATTGGCCAAACCACTGCTCAGCGGATGGGAAAGACAAATAGTTCGCTTCAAAGGCCACAAGGAAGTGATGTACCGCGCGCCCTGCGGCCGTCGCCTACGAAACATGCGCGAGTTACATCACTACTTACGTTCAATAGACAGCGACTTGCCCGTAGATCTGTTCGACTTCCACTACTCAACGCATTGCCTCGCGGAGTTCGTGCTCAATAAATGTCTAGTGGGGAAGAAGGACCTATCGCACGGCAAAGAGAACGTCCCAGTACCCTGCGTGAACTACTACGACGACTCGCTACCGGAGTTCTGTTCGTACAACACCGAGCGCACGCCCACAGCCGGCGTGCCGCTCAACCTGGAGCCCGAGTTCCTGTGCGGCTGTGACTGTACCGACGACTGTCAGGATAAATCAAAATGCGCTTGTTGGAAAATGACGCTAGAGGGCGCTCGCACCATCGGGCTGCGTGGACCTAATGTGGGCTATGTTTATAAGAGACTGCCCGAACCGTTACCTTCTGGGATATATGAGTGCAATTCTAGGTGTAAATGCAAGCATACATGTCTAAACCGCGTGGCGCAGCACCCACTACAATTGAAATTACAAGTATTTAAAACTCCGAACCGTGGTTGGGGTATCCGGGCTCTGAACGACGTGCCAAAAGGTTCCTTCTTATGCGTGTACGCTGGTAACCTGCTCACAGATGCTACGGCTAACTTGGACGGTTTGAACGAGGGCGACGAATATCTAGCAGAATTAGATTACATAGAAGTAGTGGAACAAATGAAAGAGGGATATGAAGAGGATATTCCTGAAGCCGATAAGAAATTGGACAAGAAAGAAACTAAGGATGATGAAGAAAGTGACGAGGATGAACCGTCATCCTCCGAGGAAGAGGAGAAGGCGGATAAGAATGACAAAGAGGATGATGACTTTAGACCAGGATACATTGGACTAGGCGTCACGGAGTTCAGCAAACGTCTCCGTAAACGCGAGAAATCAAAGAAAGATAAAGAAAAATCGGCGACTGATGAGAAAGAAAAGGAGAAAGATACGACTAAAGAAGCGAATGGTGAAGAAGATTGTATTACTATTAGTGATGATGAAGAAGTACGAGAACCATCGAGATTCATGGCTCAAACGAACATGGGAGCTAACGAGTATATTTCTAAATACAAgtctgttcgcacgttattcggtaaggacgaggcatgctatatcatggacgctaaggttcaaggcaacattggcagatatctcaatcactcctgctgcccaaatgtatttgtacaaaacgtgttcgtggacacccatgacccacgtttcccttgggtggcgttcttcgcgctgtcacacatcaaagcaggtaccgagctcacttggaattacaactatgacgttggttccgttccggggaagatactttattgttactgtggagctcctaactgtagggggcggctgttgtaa
Protein Sequence
MPQLAAIDGSGGDKNRILQDNIKLDKLEAELTETSIEFINTKAGEGSSDYTAKAKVSRIDDKEIEDVNTEIDAIISKTNVTAEKDESDEKCDEIESKTADDPDEIEDEDMELRWDDDDASNQAMGDDIRNADAKNEDILTEDQLLEDTSDLLTKDMTEMPSDGDPKVSEANLDSLTRDNNFKEIETTKDSEISPKLDIPTDKAEDELLGENNLNTEAINSPEMDFPTEGSMGRDDEKSLGDELSGENNLNTEAINSPEMDFPAEGSMDRDDEKSLGDELLGENNLNTEAINSPDMDFPAEGSMDRDYEKSLGDELLGENDLNTEAINSPDMDFPAEQSMDRDDINVLEEKLLEESEIVTEAAVIAQANEILEEKSIDEPIKETESVKDNLLKEVTTDEQTKENPVDIIEDELLAETESNTETESSTLKLKSFTDVILIKDNDDIMSEENLLKEPDPKGESSLIISEKDIEFSKTVPEKQAPVNKEDNDDVLLEEKLLQETETAEVIPESDVTMDVDDEEEGELLKDDECQEDSCTPMDVDNTDTSIDDQAKIEDKIINQTVNQSEVAKKDIAFPIDDQTNIEKVDETKDEVENMDQSDDQSKIIEEDIDQPIKDTTKAVDITKDTPIEDEPSINEKIVDQGITEKETIDEQIDVQTKMGASNKDPLILESDTKEQSIKSPEQIASLTVCNTPNILVEDLKKTTPEKEIKNKTDPEEPTADTENINKNIDLDKPEKSKETINPETSLDKNEDVDKISANNSSIFLEDSCPIKTDHGLHRPDVMLEIPTQELIDMDDTDLSMNLDHSEMLDSLNYVDKNAEDDIVHEKTIDKSVIDDVIVSDDIVTDGAAVSEKSVDNTIADDDTVKQKPVDQKAIATETTAVDKNVTDDDTVKEKSLVQEAIVTESTVGEVQTESNIVESDRKDDDALVQSTVEENMEKMFADDEPGVAKEIAECIASTSQAQVPTQHPSTSITRMTPDTSDEVPEIDDSLGLLAESAGRMMEDDEEPDDDFDGDDDDDFDQDESSNQISAEQSEDSNPAALESEPVRDQEDKELETPDPKDEEFPFMMCDSTSQDKAEKMDVEEEYGTVQLEAETVNEMNEEAKSAVDALLNADNPADEQAENQQETTDQMDIETVKLSDTSDNEVDVEPTKVQTTVAVSSKESEEKQKSSPSKSPNKSNISPKQSPSKLSQSPSKKSPSKMKNLAITTQEASSVVNIVDLEESSSSEDDIQEVQKQPETTVDDKSPSPESAVTNVNIPTGIDIMCTSGGNTSEITTKDNRSQVVISGVPKPPPHKPARLNTSEVTIKTASNTEPLIIPETKINEQNQTQAKPKLSLEIFSLDSDDDESAAKEKATPTSPDKMTALELDKARETSKCINYCCTSDSKVPYKVAEASVIAYYDAGRKRRSVVCQPCADVVTARTKNLIQGIKELTPLLDLDMGKLSQDLVEISDSESEDEEMSPEEPKESIGEKGAKFIEDNLAKFLNDTWKKYDMDLRLTETQLMLDDEIEKLEKDSKEIDAMLNECQVATDKLRCELYATFECRRQQQPSLVICDTPDSKYIGLEEKINPPAVAESIIETRQAKRRLSSTSETPAKRPAIPLGYAPLDAGDAKEKAAIPGPDIKLDDDKDISVVKLSAEAAPADLPPPGEISRPPLRVGMPVYAMKNAFGPWLKGRVVEIQPKNTSGGNPFSLCLVKFDHKVKTNGKVLPARCIAYSEPADVRMTIGTRLIALFKDSNKRESYYSGVVAEIPNPVNNYRYLVFFDDGYAQYVQHQFTRLVCESSPLVWEEVHPFSREFVREYLLAYPERPMVRLHEGQHLKTEWNGKWWSSRVTRVDASLAQVMFVGDGRREWVYRGSTRLAPLYLELRAAERHRPRPMPRSKAQPRFNMPYVEYTRSDEQESSKQVDAQAQQQQQQQQQLQNEEIRRQRSVAKKSTSAPPQVLPPSQQVMPPAHMDPVTSRVVYYTPKNAVKPLKMVPHRCGARCKRSDVLSLKELRTYNPLAKPLLSGWERQIVRFKGHKEVMYRAPCGRRLRNMRELHHYLRSIDSDLPVDLFDFHYSTHCLAEFVLNKCLVGKKDLSHGKENVPVPCVNYYDDSLPEFCSYNTERTPTAGVPLNLEPEFLCGCDCTDDCQDKSKCACWKMTLEGARTIGLRGPNVGYVYKRLPEPLPSGIYECNSRCKCKHTCLNRVAQHPLQLKLQVFKTPNRGWGIRALNDVPKGSFLCVYAGNLLTDATANLDGLNEGDEYLAELDYIEVVEQMKEGYEEDIPEADKKLDKKETKDDEESDEDEPSSSEEEEKADKNDKEDDDFRPGYIGLGVTEFSKRLRKREKSKKDKEKSATDEKEKEKDTTKEANGEEDCITISDDEEVREPSRFMAQTNMGANEYISKYKSVRTLFGKDEACYIMDAKVQGNIGRYLNHSCCPNVFVQNVFVDTHDPRFPWVAFFALSHIKAGTELTWNYNYDVGSVPGKILYCYCGAPNCRGRLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00037842;
90% Identity
-
80% Identity
-