Basic Information

Gene Symbol
-
Assembly
GCA_948473465.1
Location
OX419624.1:15609892-15613399[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00084 0.059 14.1 0.8 1 23 295 318 295 318 0.94
2 12 0.0039 0.28 12.0 2.4 1 19 328 346 328 350 0.92
3 12 2.2e-05 0.0016 19.1 3.7 2 23 356 377 355 377 0.97
4 12 0.0011 0.075 13.8 0.7 1 23 381 404 381 404 0.94
5 12 0.0011 0.077 13.8 0.7 1 23 407 429 407 429 0.97
6 12 0.0008 0.056 14.2 0.4 2 23 507 528 506 528 0.96
7 12 0.12 8.3 7.4 0.3 2 23 548 570 547 570 0.96
8 12 8.8e-07 6.2e-05 23.5 4.1 1 23 576 598 576 598 0.98
9 12 0.00035 0.024 15.3 2.6 1 23 603 625 603 625 0.98
10 12 0.00063 0.044 14.5 5.3 2 21 632 651 631 654 0.95
11 12 7.2 5e+02 1.8 1.5 1 19 662 680 662 681 0.86
12 12 0.77 54 4.8 2.8 3 19 694 710 693 715 0.90

Sequence Information

Coding Sequence
ATGGAAGGCGAAGAGTGTAATTCGAATTCGGAAGTGCCTCACCCAATACTGTTCATACCAAGAGTGTGTACACCGTTGGTCACCACCAGTGAAATGTCAGAACGTCTGTTATTACACTTGAACATCTCAACACCAGACCCAGATGGCAATGAGATTGCCATATACAAGGGTGTCTGTGATGTAAAGATCATGGAAGGCAGGGATATCAACATCAGGTACGCATCACCAAATAGTCTCTCAAGCATTGACAACATAAATGTGATTCTGACTGAAGCTAATCAGATAACAATACCTGCTTACAATGATTCTCAAGTCTGGATTGACCCGGCTAGGAGCCCATTTGTGTACAACCGTTGTGACTCACCGCCGCTGGAGACTTACACCATACATGAGAGTAATGACAACCATATTACATTTGAGCAGCACAACACATATATTACTCAAAATGTGTATAATTACAACGAAGCTATTCAGTACTCTCCTGTCTGTGAGGAACAAAAGTCAGTCAAGAAGATACAAGAAAATGTGCGGAATTCAGAAATCCATAACTTGTATGAGGACGAAGAGCTTGAATGTGGGGTGTTCCTGTCTCAGTTGTCTGAAGAGATCAATGAGAAAGATGCTAGGGCACGAGACGAGAGGAAGTTTGTTGGTCTGCAGACGGACAATGGAGCGTTGAAACAGCTGATGTCTACAAATATACAGTCTGTGTCGAGGCAGCAGAAGACTATATTGTTTTTAGGTCATGACTCTGGGTCTGGTCAGACGGTACAGAATATTGCCATCAATGATCCTTCACTGGAGTGCGTCGGAGCTGGTGAAGTGGAGAGTGAATTTACTATAGGAGACTCCAACATTACAAATAATCCACGCGCGAAAAAATACCAGTGCAACAAATGCAAACAGATATTTGACCAATTATCTGCCTTTAAACTGCACGTGGTCAGTAGCCACCGGCGCTCCGCCTCCGGCAACCTCAAGTTCATGTGCACAGAATGCGGGAAAAGTTTGAAGAACCAAGAAAAGTTTGAGCAACACTGTCTCGGTCACGGCGACCCAGATTTGGAATGTAACAAGTGCCACAAAGTCTTCGCGTCAAAATTCACCTTACGCAATCACCGTAAGATACATTCTCGAATGTTCCCCTGCAGCTACTGTGCAAAGAGTTTTGCCACGATGGAGGAATTGCACGCACATTCATCAAAAATTCACTTCAAATTTATGTGCGAAGCGTGTTCGTTTGTTTGCGAAACTTCATCTGAGTTGACGGCTCACCAAAGAGCTCATAATAAGACCAGCTCGAACTCTTCGACGAGTTCCAGTGAATCTGAATTCGCTGAAGGCGTGTTTGAGGGGAGTTTCGAGGGGCTAAGTGATATTTCGGTGGCAGAAGAGTTAGTCAAGCAAGAGGAGGATGAACATCTACAAACTCCAGACTCAGTTATCGCGAAGGTGATGTCCAACAATATATTTCAATCTCAATCCAAGACGAGCAAGACACAGAGGAAGTATAACAAGACATGCGAAGTGTGTCTAAAAAAGTTCGACCGGATCGGTGACCTCAAGAGGCATCTCATCGAGCACGTGATAAGGAGCACCCTGGCCAAGAACCCAGTGAACAAGTTCGGGGTCCTCAACATCCGCTGTGAGATCTGTCAGGAACGGGTATTTTCAAAAATCGATAGATACAAAGCCCATTTGAGGGAACATGCGAAGCTCACTCTCTACAAGTGCACCTTTTGCGACAAATCCTTCAGTGACTCGAGCAACTTTTCTAAGCACAAAAAAATCCACGGCACCACCTACTTCCAATGTGACATGTGCCAACGTAAGTTCAATTCCAAGAAAATGATCACGCAGCATATGGAGTACCATAACAAAACTCAGCCTATGAAATGTCAATATTGCGATAAAGTGTTCCATTTTGAGTCTATGCTCAATAAGCATATGAGATGCTCGCATACCAAGGTAACGACGAGCAGATTCAGGTGTAGGTTCTGCCGTCAGTACTTCAGAAGTTTGAAGGAGAAGTGGGACCATGAATGGGCAGCTCATAATGCTAGGAAAGTGATTGTGGATTGTCTGTTCTGTGAGTCCAGGTTTAGGAAGTATTCAGAGTTAAAGCGACATTGTATGGAGGAGCATGATACGGTCATACCTCCAGCTAAAAAATCGCTTAGATGGAAGTATACGAAGTTGAGAATGATTGAAGATCAGTAG
Protein Sequence
MEGEECNSNSEVPHPILFIPRVCTPLVTTSEMSERLLLHLNISTPDPDGNEIAIYKGVCDVKIMEGRDINIRYASPNSLSSIDNINVILTEANQITIPAYNDSQVWIDPARSPFVYNRCDSPPLETYTIHESNDNHITFEQHNTYITQNVYNYNEAIQYSPVCEEQKSVKKIQENVRNSEIHNLYEDEELECGVFLSQLSEEINEKDARARDERKFVGLQTDNGALKQLMSTNIQSVSRQQKTILFLGHDSGSGQTVQNIAINDPSLECVGAGEVESEFTIGDSNITNNPRAKKYQCNKCKQIFDQLSAFKLHVVSSHRRSASGNLKFMCTECGKSLKNQEKFEQHCLGHGDPDLECNKCHKVFASKFTLRNHRKIHSRMFPCSYCAKSFATMEELHAHSSKIHFKFMCEACSFVCETSSELTAHQRAHNKTSSNSSTSSSESEFAEGVFEGSFEGLSDISVAEELVKQEEDEHLQTPDSVIAKVMSNNIFQSQSKTSKTQRKYNKTCEVCLKKFDRIGDLKRHLIEHVIRSTLAKNPVNKFGVLNIRCEICQERVFSKIDRYKAHLREHAKLTLYKCTFCDKSFSDSSNFSKHKKIHGTTYFQCDMCQRKFNSKKMITQHMEYHNKTQPMKCQYCDKVFHFESMLNKHMRCSHTKVTTSRFRCRFCRQYFRSLKEKWDHEWAAHNARKVIVDCLFCESRFRKYSELKRHCMEEHDTVIPPAKKSLRWKYTKLRMIEDQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01441402;
90% Identity
iTF_00037191;
80% Identity
-