Llea004274.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Lithophane leautieri
Gene Symbol
E2f2
Assembly
GCA_949152455.1
Location
OX424461.1:14427808-14445964[+]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.2e-30 1.6e-26 92.5 0.1 2 64 125 187 124 188 0.98

Sequence Information

Coding Sequence
ATGCCGAGAGGGGTGAAGCGAGGGCCGGCGGAGGGCGAGGCCGAGGTGGTAGTACGCGCTGGCGCATCTCCTTCGCATACCACGCTACTAGACGATAGCCCTAGCCAGCCCATCAGCTATCACCTGCTCGACCACGGCTATGGCGCCACGCCACAGCATCAGATCCGGCGCGAGGCGCCTACGGCACCGCCGAAGACGTCTGAAGCGGTGAAAAGAAGACTGAACCTGAGTGAGAGCAGTTCCGGCAGCCAGGGTCATGTGGTGCCCATGAAAGCCGACTTCAAAACGCCCAAACAGAAACGCGTGAAGGTTCTCACGCCCTACAGTCGACCGTCCAGTTCCATGAAAAAGTACACCGAACGTTCCAGGTTTGACACATCATTAGGTTTACTCACAAAAAAGTTCGTTGCGTTGCTGAAGTCCTCGCCCAATGGCGTTCTAGACTTGAACATAGCTGCAGAACACTTATCGGTCCAAAAACGTCGTATCTACGACATCACAAACGTACTAGAGGGTATAGGAATATTAGAGAAGAGAtccaaaaataatatacaatggaAATATGGCGtgggcgcggcgggcggcgcgtgcggcggcgacgcggcgcgcgcgcggcggctgcggcgcgaCGTGCGCGGGCTGGCGGCGCGCGAGGCGCGCGTGTGTCGCGCCGTGGGCGTGGCCGAGCACGCGCTCAGCGCGCTGTCGGCTGACCACGGCGCGCGTGCCTACATCACGTACGCCGACCTTCGCTCCATCCGGGACTTCCGCAACCAGACCGTCATACCCATCAAGGCCCCGCCCGATACGCGGCTCAGCGTACCCCATCCTGACGAGAAAGGCTTCATGATACATTTGAAATCTATGTCGGGAGAAATCGAAGTCTACCTCTGTCCAAAAGAACGTCCTCCTTCGCCTGCTTCGTCGAGCGGCCCGTTGCCGGCCGACCCGCTGCTGGAAGACAACAAGGCTCTGCTGGCTCCGCTCATAGCACTGCTGCAGTCCAAACCCTCCACCTCCATCACCGCTGACTTCACGACGCCAATAAAACGTGAGCCTATGAGCTCGTGTTCGTCGTCGTCGTCGATGCTGGTGTGCGCGCCGTGCGTTACGGACCCCACGCTCCCGCTGGGCGTCCCGTCCGGCCTCACGCCCGGCCTCACGCCCGGCCTCACGCCGCTCACGCCACACACGCCCCACACGCCCCATACGCCCCACACGTCGCACAGTAGCCACCACGAAGCGCTCAACACTCCTGACAACGGCGGCGCGCGAGGCCGGCTGCGCAACGCGTTGATAGCGGACAGCGACGACTTCGCGCCCATCATGGGCGGCGGGCGGTTCCAGCTGCAGACCGAGGACCAGGAGTCAGAACCGCTGGAGTTGGAGCCGTTCCTCGCGCTGGAGCCGCCCATGTCGGCCACGGACTACGGGTTCTGCCTCGATCACGACGAGGGGCTGGCGGAGCTGTTCGACTTCGAGTTCTAG
Protein Sequence
MPRGVKRGPAEGEAEVVVRAGASPSHTTLLDDSPSQPISYHLLDHGYGATPQHQIRREAPTAPPKTSEAVKRRLNLSESSSGSQGHVVPMKADFKTPKQKRVKVLTPYSRPSSSMKKYTERSRFDTSLGLLTKKFVALLKSSPNGVLDLNIAAEHLSVQKRRIYDITNVLEGIGILEKRSKNNIQWKYGVGAAGGACGGDAARARRLRRDVRGLAAREARVCRAVGVAEHALSALSADHGARAYITYADLRSIRDFRNQTVIPIKAPPDTRLSVPHPDEKGFMIHLKSMSGEIEVYLCPKERPPSPASSSGPLPADPLLEDNKALLAPLIALLQSKPSTSITADFTTPIKREPMSSCSSSSSMLVCAPCVTDPTLPLGVPSGLTPGLTPGLTPLTPHTPHTPHTPHTSHSSHHEALNTPDNGGARGRLRNALIADSDDFAPIMGGGRFQLQTEDQESEPLELEPFLALEPPMSATDYGFCLDHDEGLAELFDFEF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00122146; iTF_01084040; iTF_00622603; iTF_00301891; iTF_00150276; iTF_00404484; iTF_00869415; iTF_00931015; iTF_00932210; iTF_00282059; iTF_01435851; iTF_01151853; iTF_01332335; iTF_00637267; iTF_01491669; iTF_00822679; iTF_00636063; iTF_00794112; iTF_00444900; iTF_00685221; iTF_01362885; iTF_00973512; iTF_00040585; iTF_00041570; iTF_00771666; iTF_00711605; iTF_00851509; iTF_00042423; iTF_00363818; iTF_00071202; iTF_00121186; iTF_00176898; iTF_01093829; iTF_01339749; iTF_01439685; iTF_01338278; iTF_00237257; iTF_00757931; iTF_01440780; iTF_01092857; iTF_00745418; iTF_00274239; iTF_00425164; iTF_00790991; iTF_00790034; iTF_00445900; iTF_00017135; iTF_00017970; iTF_01076178; iTF_00147091; iTF_01532819; iTF_01063540; iTF_00677333; iTF_00821568; iTF_00907669; iTF_00830956; iTF_00038487; iTF_01526808; iTF_00186935; iTF_00120280; iTF_00906849; iTF_01025766; iTF_00448809; iTF_01030924; iTF_01029008; iTF_00374964; iTF_00674104; iTF_00726076; iTF_01361373; iTF_00036414; iTF_00037567; iTF_01245727; iTF_00809849; iTF_00808894; iTF_01525721; iTF_00049690; iTF_01342010; iTF_00124027; iTF_00123141; iTF_00446907; iTF_00039585; iTF_00043273; iTF_01246619; iTF_01029948; iTF_00888006; iTF_01027090; iTF_01028052; iTF_01119070; iTF_01116961; iTF_01118049; iTF_00111391; iTF_01192414; iTF_00843295; iTF_01506959; iTF_01507858; iTF_00824500; iTF_01506132; iTF_00796317; iTF_01264191; iTF_00708968; iTF_00300960; iTF_00951584; iTF_00928449; iTF_00299940; iTF_00373700; iTF_01424837; iTF_00172520; iTF_01061672; iTF_01064425; iTF_01531755; iTF_00850384; iTF_01062545; iTF_01534584; iTF_01230301; iTF_01533727; iTF_01084928; iTF_01259872; iTF_00273402;
90% Identity
iTF_00448809;
80% Identity
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