Basic Information

Gene Symbol
E2f2
Assembly
GCA_947086405.1
Location
OX352260.1:5739544-5764941[-]

Transcription Factor Domain

TF Family
E2F
Domain
E2F_TDP domain
PFAM
PF02319
TF Group
Helix-turn-helix
Description
This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2e-30 1.6e-26 92.2 0.1 2 64 124 186 123 187 0.98

Sequence Information

Coding Sequence
ATGCCGAGGGGGGTGAAGCGAGGTCCGACGGAGAGCGAACCGGTGGTTGTGCGCGCCGGGGCGTCTCCGTCGCAGACCACGCTGCTAGATGACAGCCCTAGCCAGCCCATCAGCTATCACCTGCTCGACCATGGCTATGGCGCTACGCCACAGCACCAGATTAGGCGTGAAACGCTATCGGTGCCGCCGAAGACGTCAGAAGCGGTGAAACGAAGACTGAACCTGAGCGAGAGCAGCTCAGGCAGCCAGGGCCACGTGGTCCCCATGAAGGCGGACTTCAAGACGCCCAAACAGAAGCGCGTCAAAGTTCTCACGCCATACAGTCGGCCGTCCAGTTCTATGAAAAAATACACCGAACGTTCCAGGTTCGATACATCATTAGGTTTACTTACAAAGAAGTTTGTCGCTCTGCTGAGGTCCTCTCCCAACGGAGTGCTTGACTTAAACATAGCGGCGGAACACCTGTCGGTGCAGAAACGTCGCATTTACGACATCACCAACGTGCTAGAGGGCATAGGAATATTAGAGAAGAGATCTAAAAACAATATACAATGGAAGTGTGCCGGGGCGGGCAGCAGCGTGGGCGCCGACGAGGACAGCGCGCGGCGGCTGCGGCGCGAGGTGCGCGCGCTGGCGGCGCGCGAGGCCCGCGTCACGCGCGCCGTGGCCGTCGCCGAGCACGCGCTCAGCCGGCTGTCGGCCGAGCACGGCGGCGCCGCCTACATCACCTACGGCGACCTGCGCTCCATACGGGACTTCAGGAACCAGACCGTCATACCCATCAAGGCGCCCCCGGATACCAGGCTTAGTGTACCTCACCCCGACGAGAAAGGCTACATGATACACTTAAAGTCTATGTCAGGTGAAATAGAAGTCTACCTCTGTCCCAAAGAGAGACCACTCACACCACCTCCTTCGTCGCTGCCGACCGACCCGCTGCTGGAGGACAACAAGGCGCTGCTGGCGCCCCTCATCGCGCAGCTGCAGTCCATGCCCACCAGTTCAATCACTGCGGCCTTCACGACGCCTGTGAAGCGCGAGCCGGAGGAGCCGCCGCCGGCCCGCGGGCTGGTGGTGCGCACGCCGTGCGTGACGGACCCCACGCTGCCGCTGGGCCCCCTCGCCGCGCCCCTCTCGCCGCACCGCCCCGCCTGCCTCACGCCACACCCCGCACCCTCCACCTCCGCGCTCTCCACGCCCGACAGCGGAGGCGCGCGGGGTCGCCTGCGGAACGCGCTCATCGCGGACAGCGACGATTTCGCGCCCATCATGGGCGGCGGACGGTTCCAGCTGCAGACTGAAGACCAGGAGTCAGAGCCGCTCGAGTTGGAGCCGTTCCTCGCGCTGGAGCCGCCCATGTCGGCCACCGACTACGGGTTCTGTCTCGACCACGACGAGGGGCTCTCGGAACTTTTCGACTTCGAGTTTTAG
Protein Sequence
MPRGVKRGPTESEPVVVRAGASPSQTTLLDDSPSQPISYHLLDHGYGATPQHQIRRETLSVPPKTSEAVKRRLNLSESSSGSQGHVVPMKADFKTPKQKRVKVLTPYSRPSSSMKKYTERSRFDTSLGLLTKKFVALLRSSPNGVLDLNIAAEHLSVQKRRIYDITNVLEGIGILEKRSKNNIQWKCAGAGSSVGADEDSARRLRREVRALAAREARVTRAVAVAEHALSRLSAEHGGAAYITYGDLRSIRDFRNQTVIPIKAPPDTRLSVPHPDEKGYMIHLKSMSGEIEVYLCPKERPLTPPPSSLPTDPLLEDNKALLAPLIAQLQSMPTSSITAAFTTPVKREPEEPPPARGLVVRTPCVTDPTLPLGPLAAPLSPHRPACLTPHPAPSTSALSTPDSGGARGRLRNALIADSDDFAPIMGGGRFQLQTEDQESEPLELEPFLALEPPMSATDYGFCLDHDEGLSELFDFEF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00905903;
90% Identity
iTF_00994163;
80% Identity
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