Lcyl013488.1
Basic Information
- Insect
- Leptogaster cylindrica
- Gene Symbol
- MBD3
- Assembly
- GCA_963082835.1
- Location
- OY720107.1:5639415-5640678[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.2e-21 1e-17 64.2 0.0 9 73 13 72 5 76 0.89 2 2 1.7e-05 0.056 13.8 0.0 29 74 124 177 80 180 0.86
Sequence Information
- Coding Sequence
- ATGAACGTAAACGCTGACCGAAGAAGAACAGTTGTTGATGCTCTACCAAAAGGGTGGCAAAGAGAAGaagttttaagaaaaactGGGTTGTCTGCTGGTAAAGTGGATGTTTACTATTACAgTCCCACGGgaaagaaaatcgaaaataaaccACAATTAGCCCGTCAATTAGGTGACACCCTTGATGTATCaacatttgattttcaaaGTGGTAAGCTATTGCAAAGTAGCCAACAAATATGTGTACAGCGTACCACCGCCAGCACGTTAAAGCGCAAATTACCTGCTGGTACAACGGCTATTTGTAGTTCATCCAGCAGTGCTAGTATGTCTTCAGCGTTTCGACACCACCTAGAGCTCAGCCGAGGAATGAGAAATGATATATCTCTGGTGCCACCGATTCGGCAAACAGCATCGATTTTCAAGCAGCCTGTGACTGTGATCCGCAACCACGAGGGAAAGGTTAAGAACGACTTGAAACATGGCACACAGGAGAAACCGAAACAGCTCTTTTGGGAGAAGCGGCTTGAGGGATTGCGGGCTTGCGATGTTTCGGGCATGGAATACGACTCCATTGATTTGCCGCGTGGAATTAAGCCAGTAGGGCCAAATGTAACCGAGCACACACTCCTCCAGTCTGTGGCCACAGCTCTTCATGTCTCCAATCAGCCCGTTACTGGACAGACCTCGTCAAAAAACTTGCTTGCCACCAATTCCGGTGTCTTCCTCAATCCGGAACAGCCACTGATGTATGCAATTTCGATTAATGAGGATGATATCAGGAGACAAGAGGATCGCGTTACCCTCGCTAGACGACGAATACAAGAGATTCTAAAAGGTTAA
- Protein Sequence
- MNVNADRRRTVVDALPKGWQREEVLRKTGLSAGKVDVYYYSPTGKKIENKPQLARQLGDTLDVSTFDFQSGKLLQSSQQICVQRTTASTLKRKLPAGTTAICSSSSSASMSSAFRHHLELSRGMRNDISLVPPIRQTASIFKQPVTVIRNHEGKVKNDLKHGTQEKPKQLFWEKRLEGLRACDVSGMEYDSIDLPRGIKPVGPNVTEHTLLQSVATALHVSNQPVTGQTSSKNLLATNSGVFLNPEQPLMYAISINEDDIRRQEDRVTLARRRIQEILKG
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01431916;
- 90% Identity
- -
- 80% Identity
- -