Basic Information

Gene Symbol
-
Assembly
GCA_949152495.1
Location
OX424446.1:17657251-17661726[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 19 0.023 3.6 9.4 3.1 1 23 410 432 410 432 0.97
2 19 0.019 2.9 9.6 0.5 2 23 469 490 468 490 0.96
3 19 8.1e-05 0.012 17.1 1.2 1 23 560 582 560 582 0.97
4 19 0.085 13 7.6 3.1 1 23 585 607 585 607 0.98
5 19 1.5e-05 0.0024 19.4 0.8 2 23 659 681 658 681 0.93
6 19 8.3e-05 0.013 17.1 1.3 1 23 687 709 687 709 0.95
7 19 0.00051 0.078 14.6 0.7 1 21 715 735 715 739 0.92
8 19 6.4e-05 0.0098 17.4 0.9 2 23 814 835 813 835 0.95
9 19 0.00055 0.084 14.5 4.1 1 23 885 907 885 907 0.96
10 19 0.00034 0.052 15.1 0.7 1 20 912 931 912 933 0.94
11 19 0.057 8.7 8.1 0.3 2 23 944 965 944 965 0.97
12 19 3.5e-05 0.0053 18.3 0.6 2 23 1004 1025 1003 1025 0.97
13 19 3.1e-05 0.0048 18.4 1.6 1 23 1030 1052 1030 1052 0.95
14 19 0.00018 0.027 16.0 2.8 1 23 1058 1080 1058 1080 0.98
15 19 5.6e-06 0.00085 20.7 0.4 1 23 1096 1118 1096 1118 0.95
16 19 4.5e-07 6.9e-05 24.2 0.6 1 23 1124 1146 1124 1146 0.99
17 19 4.9e-05 0.0075 17.8 0.2 1 23 1152 1174 1152 1174 0.97
18 19 0.029 4.4 9.0 6.9 1 23 1180 1202 1180 1202 0.96
19 19 0.0062 0.95 11.2 0.6 1 20 1208 1227 1208 1229 0.90

Sequence Information

Coding Sequence
ATGGACGCCGTAGAAATAAATACGTCGGGTTCGCCGCAGAGTGAGGACGCGATCGCGTCCGCGATGAAAATATGCCGCGTGTGCCTGCTCGACAACCCGATGATGCGCGACCTCTTCCTGGACGGTGAGGTCGCGTCCCTCTCGATGAAAGCGATGAGCTTCACCAACGTTAAGATGTTACCAGGCGATGGTCTACCGGCACAGGTATGCTGCGTGTGCGCCGACAAACTGGAATCGGCGTATGAATTTAAGTTACAAGTGGAGCAGGCCGACAGTGTCCTAAGGGACAGGTTTGTCGGAGGGATAATAAAGGAGGAATTGTTTCTTAACGAGGTCGAGATACATTTAGATGCCGATAGGAATGATATAGAGGAGATGAATGTCAATACCGACTACGAATCTACTGTCGCAGTTCTGCCAGAAGAATCAGACGTCGATAAGAACTTTTTGAAAGAGCAATTAATGATCTTGGAAGATGAGAAATTGACACATACGGAAGAAATGCAACAAGATTTGGAACAGGATCATTCGCAGGAGATTACACAAGAAGTTAGTCAGAGTATTGTAGAAGAGCAGCAAGAATTAGTTGACACGAAGGATAATGATATGTCAAGTACTATCAATGAATCTAGGAACCAAAAACTTTGCATGaacgaaaatattattccGAGTTATATAGAGGCAATTCCAACAGAGGAACATGATTACATTATGCAGCAACAGTGTGTGTTGCCAGCTGAACAATTTCCTTTGCAAGAAAGTATACAGATGGACACACAAGTTGAACAAAGTATAGTGGAATGCCAAGAAACATTATCTGAATTTAATCAAGAGAATCAAGTTGAACAAATTGAAGAGAATGAAGCAGAACAAATTGAAGAGAATCAAGCTGAACAAATTCAAGAATATCAAGCGGAGCAAATTCAAGAATATCAAGCGGAGCAAATTCAAGAGACTCAAGTGGAGCAAATTCAAGAAAATCAATCTGAGCAAAATCAAACTGAcaacaagaaattttttaatgaagaaatgTCAGCGACTGATAACGAACCGGCGAAGCCGGTAGTGAAACAAGATTCACCTCAAAACGAAACCAGAAGAAGTAAACGTAGATTAGCTCGTCGAACGTTCGCTGAACGGGATTCCGACGAAGAGAACTATTTCGAAAATCTGAATCTTAGTTCTAGACTGAAAAAAGCACAGGCGGATAAGGCGGAGAAGATCTTCTTTATGTGTTATTTGTGTGACAAACAGTTCCTGTCGAAGAGCGTTCTGAAGGAGCACATGCACTCTCATGAAGAAGTGAGGAAAGCGCTCTCCCTAAAGAAAACGCCGGAGAAGCCGCAGAAGATGCAGACCAACATATCCGCCACGAAGACTCCGCCATCTGGAAAAAAAGCCAACAAGTGCCCTTATTGCGGTAAAGAGTATCTGTACATAATCTCGTTTACTAAGCACATTAAACAGCACGAGCGGGAGCGAGAGGAGGCGAAAGAGGACCCTATGCCGCTCGAAATTTCGTTCCACGAAGATGAGCATAGTCTAGACTTTGATGGTAACAATTCGGACAGAGAATGTAGAAGACGAACGAGGAGAGGAAGTATAGCCGACGGGAACGACGACGCCACGACGAGCGACAACGAACAcgataaaagaagaaaacggAATCACGTCGAATTCGCATGCGACAAATGTCCAGAGAAATTTGATACGAAGCGAAGCTTGCAAAAGCACTCGCTCACGCACGTTAGCTTCAAGTGCAACCTGTGTCACGACGAGTACGACAGTCTGGAGCAACTGAGAAATCATCGAACGAAACACGTGGTCGAAGGCGTACTCAACGAGCAGGATTTGGAAGAAGACATGAGACAGATGATGGCCAAGAGCGTCGAGAACTACGATGACGAAGACAACAAAAACaacgaggaagaggaggacAATGACGGCGAATTCATCGAACATGCGAAGGAACTCAAGTGTCAGAAGTGTCCGATGACGTTCTCGCGCAAGAAGTTGCTGTCCAGACACATGGAGGCGGCGCATTCTGGAACTAACAGCTACGATTGCAAGATATGTCGTCAACAATTCACGCGGAAGGATCTTCTGCGCAGACACGCCGAGCAGCACGCGCGAGTAAAGACCTACAAGTGCACTCAGTGCAACAAAACTTTCGGCAACGAGCTCACTCTGAGAAATCACCTGATCGCCACGAATCACAAGACGTTTATACATGGACAAGAATACGATCCGAACAAGCGTATAAAGCGCGTGGCCGCGAGAGCGGCGCAGAAGATCATTGACAAGATCAAAACGGAGGACGGTCTGGAGGATTACGACGACGATAACGACAATGTCGATTACGACGCCAAGTTGGACGGGCATTATTACCGCCGTAAGCGCGACGCTACACCAAAGAAGTACAATTGTAAGAAGGATTTAGAGTGCGCGACGTGTAATAAGAGATACAGTTCGAAGCAAGCGTTGACGAAGCACATGGAGCAGCATGTGAAAGACGAGAAAGCGGCGGAGAAGTTGAAGAAGGCCGCTTCGGAGAAGAAGGAGACGCAGAAGTCGAATAACATAACAGGCgataacgacgacgacgacgatgactcGGACTTCGAGAGCGGTCTCGATTGGCCGATGGACAGTCACGAATGCGTCACGTGCAAGAAACGCTACAGCACGAAGAAGTCGCTGCTGCGGCACCAGCTGCTGCACGAGGAACCGAACTTCGAGTGCGACATTTGCAACGTCAAGTTCTATCGTAAGGACAAGCTAAAGGCGCACTACGACAAGTGCTCGGAGAAGAATCCCGATCAGGTGAGAAAGTGCAATATTTGCGGCGACAGTTTCGAGAACAATGAGATCCTGCGGGAACATCGGGCCAAGCACGTCACCGAGGGTATCTTAACGGAGGAGGATTTGAGGGACATCGAGCCGAAACCGGAGGAGAAGAAACCGGGCGAGAAGATCGGCCGGAAGAGGCGAACCGATATCGTGGGCCTCGAGTGTACCGAGTGCAACAAGCAGTACACCTCCAGGAAGGGTCTTCTGCGGCACATTCAGGTACACGAGGGCAAGAAATACCTGTGCGACATATGCCCGAAGAAGTTCTATCGGCGGGAACATCTCAAGATCCACGTGGCCAAGCACAATATGATAAAGCCGTACAAGTGCACCCGCTGCACCAAGCGCTTCATCAAGGAGGAGCAGCTCAACAATCATCTGTCCAAGCACGATCGTACCTTCAAGAAGAACAAGGAAACCGACAGCTCGAAGAGATTCCTCTGCGAGATCTGCAGCAAGAGCTTCACGCAATCGACGACGCTGATAGCTCATCTGCGCGCGCACAACGGCATCAAGCCGTACGTGTGCGAGGTTTGCTCCAGGCCGTTCACCACCAACGCCTACCTGAAGATGCACATGCGCACCCACACGCAAGAACGGCCGTACATCTGTCAGTACTGCTCGCGAGCGTTCGCGCGGGCCGACACCCTGGCGAATCATCTGACGTCGCACACCGGCGAGGCCAAGTATCACTGCAAATGCTGCCCGAAGAACTTCCGGCGATTGAAGTCCCTCAAGGAGCACATGTTTATTCATACGGGTCAGCGACCTTACGAGTGTCCGACCTGCGACCGCAAGTTCAACAACAACGGCAGCCGCTACGCGCACAGCAAGCGCTGCAAGCAGAACCTCCTGCAGAATCAGAACCGCGCTCAGCAGATGATGCAGCAACAGGCGCAGCCgcaacagcagcaacagcaacctCAGCAGGTCCAGATACAAGTGCAGCAACAGCCGCAGCCGATCAGGATGCATCAGACCACGCTCGGCCAAGCGCAGATTGTCAAGGCGCAGAACATCAAGACGATCGCTATAGCTAGGCAAGAACCGACCACGGTGGCCACGACGCAGCAGGCCATGATGCAACAGGAGATACTGATGCCGCTCATTTTGCCGCTCACCGTCACCCTCACCGACGTAGGCGAGGAGGTGATACTACCCGAAGGCACGAAGATATTCACCACTTCCTAA
Protein Sequence
MDAVEINTSGSPQSEDAIASAMKICRVCLLDNPMMRDLFLDGEVASLSMKAMSFTNVKMLPGDGLPAQVCCVCADKLESAYEFKLQVEQADSVLRDRFVGGIIKEELFLNEVEIHLDADRNDIEEMNVNTDYESTVAVLPEESDVDKNFLKEQLMILEDEKLTHTEEMQQDLEQDHSQEITQEVSQSIVEEQQELVDTKDNDMSSTINESRNQKLCMNENIIPSYIEAIPTEEHDYIMQQQCVLPAEQFPLQESIQMDTQVEQSIVECQETLSEFNQENQVEQIEENEAEQIEENQAEQIQEYQAEQIQEYQAEQIQETQVEQIQENQSEQNQTDNKKFFNEEMSATDNEPAKPVVKQDSPQNETRRSKRRLARRTFAERDSDEENYFENLNLSSRLKKAQADKAEKIFFMCYLCDKQFLSKSVLKEHMHSHEEVRKALSLKKTPEKPQKMQTNISATKTPPSGKKANKCPYCGKEYLYIISFTKHIKQHEREREEAKEDPMPLEISFHEDEHSLDFDGNNSDRECRRRTRRGSIADGNDDATTSDNEHDKRRKRNHVEFACDKCPEKFDTKRSLQKHSLTHVSFKCNLCHDEYDSLEQLRNHRTKHVVEGVLNEQDLEEDMRQMMAKSVENYDDEDNKNNEEEEDNDGEFIEHAKELKCQKCPMTFSRKKLLSRHMEAAHSGTNSYDCKICRQQFTRKDLLRRHAEQHARVKTYKCTQCNKTFGNELTLRNHLIATNHKTFIHGQEYDPNKRIKRVAARAAQKIIDKIKTEDGLEDYDDDNDNVDYDAKLDGHYYRRKRDATPKKYNCKKDLECATCNKRYSSKQALTKHMEQHVKDEKAAEKLKKAASEKKETQKSNNITGDNDDDDDDSDFESGLDWPMDSHECVTCKKRYSTKKSLLRHQLLHEEPNFECDICNVKFYRKDKLKAHYDKCSEKNPDQVRKCNICGDSFENNEILREHRAKHVTEGILTEEDLRDIEPKPEEKKPGEKIGRKRRTDIVGLECTECNKQYTSRKGLLRHIQVHEGKKYLCDICPKKFYRREHLKIHVAKHNMIKPYKCTRCTKRFIKEEQLNNHLSKHDRTFKKNKETDSSKRFLCEICSKSFTQSTTLIAHLRAHNGIKPYVCEVCSRPFTTNAYLKMHMRTHTQERPYICQYCSRAFARADTLANHLTSHTGEAKYHCKCCPKNFRRLKSLKEHMFIHTGQRPYECPTCDRKFNNNGSRYAHSKRCKQNLLQNQNRAQQMMQQQAQPQQQQQQPQQVQIQVQQQPQPIRMHQTTLGQAQIVKAQNIKTIAIARQEPTTVATTQQAMMQQEILMPLILPLTVTLTDVGEEVILPEGTKIFTTS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01245372;
90% Identity
iTF_00729509;
80% Identity
-