Basic Information

Gene Symbol
znf423
Assembly
GCA_028455745.1
Location
CM052303.1:26571076-26574909[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0002 0.022 15.7 0.2 1 23 10 32 10 32 0.99
2 17 0.00025 0.028 15.4 0.6 1 23 188 211 188 211 0.95
3 17 0.37 42 5.4 0.0 2 23 222 244 221 244 0.88
4 17 0.18 20 6.4 0.1 3 23 307 327 306 327 0.97
5 17 0.0026 0.29 12.2 0.3 1 23 339 361 339 361 0.97
6 17 0.013 1.4 10.0 0.3 1 23 370 393 370 393 0.92
7 17 3.3 3.7e+02 2.4 0.2 1 23 398 421 398 421 0.91
8 17 0.2 23 6.2 2.0 2 23 495 516 495 516 0.96
9 17 0.002 0.22 12.6 0.2 1 23 521 544 521 545 0.95
10 17 2.9 3.3e+02 2.6 0.1 2 23 607 630 606 630 0.81
11 17 0.00018 0.02 15.8 1.0 2 23 646 668 645 668 0.96
12 17 0.037 4.1 8.6 1.0 1 23 677 700 677 700 0.93
13 17 0.0021 0.24 12.4 0.1 2 23 892 914 891 914 0.93
14 17 0.091 10 7.3 0.3 1 23 924 947 924 947 0.96
15 17 1.5 1.7e+02 3.5 1.3 2 23 960 981 959 981 0.95
16 17 0.42 47 5.2 0.1 2 23 990 1012 989 1012 0.93
17 17 0.094 11 7.3 3.0 1 23 1019 1042 1019 1042 0.97

Sequence Information

Coding Sequence
ATGAAGACGCACGACACCCAGAAGCCGTACCAGTGCACAGCGTGTTCCCGCGGCTACAACACAGCAGCAGCGCTGACGTCGCACATGCAGTCTCACAAGAAGCACCACCACCAATCCCAAGGCGCGACGAAGCTGCAGGACGTGGAGTACGGTCGTCGCAGCGTGTCCTCGCACAGCACATCCTCTCCGCCAGTTCCTAGTTCCCCGTCGCCCTCTCTGAACCTAGCTCTGAATCCTAGAACAGGATTGAAGAGCTCGCACGGCAGCGCGTCGAACACGCCGATCCTGAGCTCTCCACTGAAGCTGGCCTGCATGTACTGCACGCGTGACTCGTTCAGTTGCATGCAGCAGCTGCAGATGCACGTGCACACGATGCACCAGGCGATTCTGAGCGGGGAGAGCGTGGCGGTGCCTCCGTCTCCCAGCAGGACCACCGATCAAGCTGGTTACCAGCGCGAGAAGGGATCGTTGCGATCGGAAGGATCCTCGAAGGATCATCACGAGAGGAAGTATCAGGAGGACGCGGAGAGATCGACGGACAAGGACCAGTTCGAGAACGCGTTCACGTGTAACCAGTGCACGATGAAGTTCTCCACGTTGGCCTCGTTGAGGGACCACCTGGTCTCGATCCACAGAACCGACGGATTCGGCTCGGCGCTGATGATGTGTCCTCTCTGCGGCATCCCCTGCGCCTCTGCCGCGGCCTACGCGGAGCACTATGTCCTGCAGCACTGCGAGAATAGGAGATTAGGGCCCCTGGAGGGCGCAGAGTACGGGGACACGAAGATCAACGGAACCTACAGCGACTCGAAGGGTTCCAGACCTCAGAAGACTAGGGATTCGGTCTCGGAGCCGGCCGATCTGACCAGCAAACATTCCAGACCCACCGAGAGCAGCTACAATCCCGGCACCCTGCTCTGTGGACAGTGCGGGGCTGCTTTGAAGGACTTCGAGTCGTTCAGAGAACACCTAGCCAGGCATCTGCAGGCTGATCAGAGGAACGACGCGATGAGACACCCCTGTCCAAAGTGCGAGGCTAGCTTCCAAGATAGGGAGGACATGCTGGCGCATCTCACCAAGCATTACCTAGGCCAGATCAGCAAGGAGTACGCGTGCGGAGCTTGCAAGAAGCTGTACCCTCATCCGGACCTGCTGCAGAGGCACCTGCTCGACAGCCACGCGCATCATCTCTACAGATGCGCGTTGTGCAGGGACACGTTCGACTCCAGAGTCGCTATACAAGTTCATTTCGCTGTGAAGCACAGTCAGGAGTGCAGGATTTATCGGTGCAACGCCTGCACCGTTCCCAACAATGAAAATTCGCCCGGGAACGCGCCTGGCGAAGGGAGAAGCTTCTTCAGGAGCGAAGCGGAGATGGCGAATCACGTCAGGAGCGTTCACGCACCGTCCACCGTTTCGAACAGCAGCCCTGTGGCTAGGAGTCCTGCGTCGACGCCTGGAGTCACCGGCAGTGCTGTACCCAGATGCGTTTTCTGCGGAATCTGTTGCAACTCGGAACTGGAGCTGCAACTTCACCTGGCCAGCCACTCGACCAGCTTGTACAGGTGTCCTATCTGCAGAGAGGGCTTCGCTGTGGAGTTCTTGCTGGACAGACACATGGCGCAGGCGCATCATTCTAGCGACCAGGCTGTCAGGAGCAGCTCCAGGGAGAACGGGAGGATCGCGAGACCTCCGAGGACGCAGGACGAGCCGAAGTCCCAAAAGAGAGGTCGATCGCCAGCATCCAGCAACAACAACTCGCTGAACCAGCGCGACAACAACAACAAACGTCCGAATTACACCAGCACAGGGTCCCAGCAGTGCGAGCTGTGCGAGAGAGGAGAGTTCGCGAACGAGGCGGAGCTTCAAGCGCACAAGAAACTGGCTCACGCTCCAGCTAAGCTTCAGACCAAGTCGCTATCCAGTCTGAGCATGACCTGCGCTTACTGTGGCGAGGTGTGTCGCTCTAGGACCGAGCTAGAGTCGCACACAAGAATCCAGCACGCCTCGAACGAGCCTGGGGGCAGACACAAGTGCAACATCTGCGACGAGGTGTGTCCCTCTGGCGCTACCCTGGCCGAGCATAAGCTGCAGAAGCACTGCAAGATCCAGCTGAGCGACACCTGCGTCGTCTGTCGGGGGAACCTCGCCTCGGAAGCTCAGTTCCTCGAGCACGTGCAGAGACACAGTCTGGAGAACGTCGATCCTCAGCAGAGACTCGACGGCTCCCTTCCTCATCTTCCTGCCGCCTGCGTGGTCTGCAGGCAGACCTTGATCAGCGACCTGGAGTGTCGTCTTCACGCCAGGCATCATCTCAGATCGTCCACCAGCTCCCAGAGCACTGCGTCCAGTCCCAGCCCCAACCAGAAGAGCCAGAGTCCAGGGTGCTGCCTATGTCTGAGAGATTACTCGGCCGACGACTTCGTCAGCCTGCCTCCCAGCCACATCACTGGCGGAGGACAGTCCTTGAGAGTCTGCAAGTCCTGCTACATCCGCCACTCCCAGGGTTTACCTATTTTAAATTCACCCTACGAACACGCTAGAGCGAAGAACGACAGAAGCTGGCCTCCCAGCAGCAAAGAGTCCCAGTGGGACGGGTCCAGGGATAGATGGGACTCGGACAGGGTGTTCAAGGCTGAAGAGAGGACTGACGAGAACTTGACTGATAATAAAAGGTGCCAGGACTGCGGCGTGAAATTCGAGGACCCTGAAGAGGTGGAGAAACACCGGCTCGCCGAGCACGAGAAACCTGCTGCTGGGTCCAACACTTACACCTGCATACAATGCCAGATGTCGTTCCCGTCAGAGGCGAAGATACAACAGCACGTCAGGAAAGAGCACCTAGAGGCTACAGGAAAAGCTTCCGTGGATGCACTGCGATGTCACCTTTGTCTCTACGAAGCCTGCAGCCCACTACAGTTGCAGAGTCACCTGATAGAGCACACTTTCGCCGGATGCGCTGCTCTCAGCTGTTACATTTGCCAGTCCCTTTTCACCGCGCCAATCGGTCTTCAGAACCACATGCTCCAAGAACACGGTCTAGGAGCGCGGCCTTACGACTGCTCGAAGTGCACCTTGAAGTTCTTCTTCAGAGCCGAGCTGGATCACCATGTGCTGACGTTCCATCGTCCCGGAGAAATGTCTCCGCCCCATGAAACTGCTCAGAACGCAGAGGTGAAAGCGACAGACGTTGAAGAGCAGAATTGTGACGATGAGATCACAGTGAAGGAAGAGATGTTGCCAGACGTTGGCGAAGAAGAGGAAGAGATTAACGTTGACGGGCAAATGGATCACGAAGAGGAGGAGAAGCAGGTAGAGATGACCCAGAGCCTGAAGACCGAGGTGGACGAGGAGGCTGCTCTTCCTGAGAAGATGGAATCGTGA
Protein Sequence
MKTHDTQKPYQCTACSRGYNTAAALTSHMQSHKKHHHQSQGATKLQDVEYGRRSVSSHSTSSPPVPSSPSPSLNLALNPRTGLKSSHGSASNTPILSSPLKLACMYCTRDSFSCMQQLQMHVHTMHQAILSGESVAVPPSPSRTTDQAGYQREKGSLRSEGSSKDHHERKYQEDAERSTDKDQFENAFTCNQCTMKFSTLASLRDHLVSIHRTDGFGSALMMCPLCGIPCASAAAYAEHYVLQHCENRRLGPLEGAEYGDTKINGTYSDSKGSRPQKTRDSVSEPADLTSKHSRPTESSYNPGTLLCGQCGAALKDFESFREHLARHLQADQRNDAMRHPCPKCEASFQDREDMLAHLTKHYLGQISKEYACGACKKLYPHPDLLQRHLLDSHAHHLYRCALCRDTFDSRVAIQVHFAVKHSQECRIYRCNACTVPNNENSPGNAPGEGRSFFRSEAEMANHVRSVHAPSTVSNSSPVARSPASTPGVTGSAVPRCVFCGICCNSELELQLHLASHSTSLYRCPICREGFAVEFLLDRHMAQAHHSSDQAVRSSSRENGRIARPPRTQDEPKSQKRGRSPASSNNNSLNQRDNNNKRPNYTSTGSQQCELCERGEFANEAELQAHKKLAHAPAKLQTKSLSSLSMTCAYCGEVCRSRTELESHTRIQHASNEPGGRHKCNICDEVCPSGATLAEHKLQKHCKIQLSDTCVVCRGNLASEAQFLEHVQRHSLENVDPQQRLDGSLPHLPAACVVCRQTLISDLECRLHARHHLRSSTSSQSTASSPSPNQKSQSPGCCLCLRDYSADDFVSLPPSHITGGGQSLRVCKSCYIRHSQGLPILNSPYEHARAKNDRSWPPSSKESQWDGSRDRWDSDRVFKAEERTDENLTDNKRCQDCGVKFEDPEEVEKHRLAEHEKPAAGSNTYTCIQCQMSFPSEAKIQQHVRKEHLEATGKASVDALRCHLCLYEACSPLQLQSHLIEHTFAGCAALSCYICQSLFTAPIGLQNHMLQEHGLGARPYDCSKCTLKFFFRAELDHHVLTFHRPGEMSPPHETAQNAEVKATDVEEQNCDDEITVKEEMLPDVGEEEEEINVDGQMDHEEEEKQVEMTQSLKTEVDEEAALPEKMES

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00684951;
90% Identity
iTF_00966184;
80% Identity
-