Basic Information

Gene Symbol
-
Assembly
GCA_905220505.1
Location
HG992161.1:19225437-19226966[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 6.4e-05 0.006 17.9 2.4 1 23 141 164 141 164 0.97
2 12 0.052 5 8.8 0.0 2 23 184 205 183 205 0.97
3 12 3.6e-05 0.0034 18.7 4.1 1 23 211 233 211 234 0.96
4 12 0.0055 0.52 11.8 1.8 1 23 241 263 241 263 0.98
5 12 9.5e-05 0.009 17.4 1.9 1 23 269 291 269 291 0.96
6 12 1.2e-05 0.0011 20.2 4.2 1 23 297 319 297 319 0.97
7 12 6.9e-06 0.00065 21.0 2.8 1 23 325 347 325 347 0.99
8 12 5.1e-07 4.8e-05 24.5 0.5 3 23 355 376 353 376 0.96
9 12 1.6 1.5e+02 4.1 0.3 6 23 383 400 381 400 0.73
10 12 0.0035 0.33 12.5 0.8 1 23 406 429 406 429 0.94
11 12 0.033 3.1 9.4 0.7 1 23 435 459 435 460 0.96
12 12 1.1e-05 0.0011 20.3 2.0 1 23 466 489 466 489 0.96

Sequence Information

Coding Sequence
ATGGATGTGAAAATATGTCGAATATGCCTTCTTAACGCCGGCACAATATTGTTGTTTGACCAACAGAAACagcattcaaataaaataatgaagtgtgTGAACATAATGATCTCAGAAGGCGACGGGTTACCGGACTCCATGTGTGCGGGCTGTGCCCAGGAGCTGGCCATAACTTACGACTTTGTTACCAAATGCGAGTCGTCAGACAAGACGCTGAGGTCTTTGAACATAGAACTGCAGCATACATTGGATATTGAGATTAAAGAAGAAGAAGTCAAAATAGAAGTCGGTGACAGTACTTTCGATGAGCCATATGATTGGAATAGTGAATATATTGAAGATAAATCTAAGGAAAACACGGTTGACTACAATGATTGCCAAAAGCTTGACTTAAAGAACCAAACAAAAACTAACGCCTTATACCCTTGTGACACATGTGGTTCTACATtcacactaaaaaaaaatctaaaaaaacatAAGTCTACATACCATAGACCCAAACTCCAGAAAGTATATAACAAAAAGCATAGAGTTAGAACTGGGCCAATACAGTGTGTAATATGTGGGCTTATGGCCCAGAGTAGGTCTGCCATGGACGCCCATGTTAGAACCCATACTGGGGAGAAACCGTTCACCTGTGATATTTGTCACATGAAATTCAGTATAAAAGGCTCTCTAAAGAAGCACATTGAAACTCACCATTCTGATAGGGAGCGAAAGTTTATCTGTGAGACATGCGGAAGCAGATTTTTTCGTAAATGTGAAATAATTGCTCATGTTCGAAGACACACAGATGAAAGACCATACGCTTGCAACTTATGTTCAAAGAAATTTCGTCAAATATCCTCACTCATACGGCATAAGTTTTCCCATACTGGAGAACGTAGACACTCTTGTCACATATGCCAAAAATCATTCTATGACAAGTCTGCTATACAAAAACATATGTCTGTTCACAGTAATGAGAAGAAGTACACTTGCCATCTCTGCAACAAGTCAGTTAAAAGTAAAAGTTCACTGGTCACTCATTTAAAAATCCACTCAAATGAAAAGCAAGTCATTTGTAACATTTGCGGCATGACATTCTCTTTGAAAGGAAACCTACAGACTCATATGAGGAGGAAACACTCAGAAAAGTCAGGACAATGTACTGTGTGCATGAAAACATACCCAGACTTGGATGTGCATATGCGTAAACACACAGGGGAACGTCCGTTTGCTTGCAAGAGTTGTGATCAAGCATATGCTACCCAACGCAGCCTGTCATACCATATAATGTTTAAGCATGAAAATGCAGATAAGTTCAAATGTTCGATAGGGGAGTGTATAAAAACGTTTCCCACCGGTAAATTACTAGAGATGCATTTATTAAAGCATCATACAAACCACACGCCTTATGTGTGTCCACACTGTTCCAGGGGGTTCTTCAGGACCAGTGACCTCACACGGCACTTAAAAGGTAGTCACATGGACACTACCAAGATCAGTTTCAAAACACAAGATCAAGTGATCATAGAAGGAATCAAATAA
Protein Sequence
MDVKICRICLLNAGTILLFDQQKQHSNKIMKCVNIMISEGDGLPDSMCAGCAQELAITYDFVTKCESSDKTLRSLNIELQHTLDIEIKEEEVKIEVGDSTFDEPYDWNSEYIEDKSKENTVDYNDCQKLDLKNQTKTNALYPCDTCGSTFTLKKNLKKHKSTYHRPKLQKVYNKKHRVRTGPIQCVICGLMAQSRSAMDAHVRTHTGEKPFTCDICHMKFSIKGSLKKHIETHHSDRERKFICETCGSRFFRKCEIIAHVRRHTDERPYACNLCSKKFRQISSLIRHKFSHTGERRHSCHICQKSFYDKSAIQKHMSVHSNEKKYTCHLCNKSVKSKSSLVTHLKIHSNEKQVICNICGMTFSLKGNLQTHMRRKHSEKSGQCTVCMKTYPDLDVHMRKHTGERPFACKSCDQAYATQRSLSYHIMFKHENADKFKCSIGECIKTFPTGKLLEMHLLKHHTNHTPYVCPHCSRGFFRTSDLTRHLKGSHMDTTKISFKTQDQVIIEGIK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00063797; iTF_01010613;
90% Identity
-
80% Identity
-