Isal015312.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Ithomia salapia
Gene Symbol
MBD2
Assembly
GCA_028829205.1
Location
JAPOND010000175.1:1872929-1884424[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 5e-17 1.5e-13 50.9 0.0 7 70 242 305 238 309 0.93

Sequence Information

Coding Sequence
ATGATCATTTTAGCAAAATTGGAAGTCTGTATCTGTCTACTTACAGatgaTATTGAAGAACAACCTGAAGTCAAAATAGAACCAGAAGAAAAAGAGGATGATAATGATGAAGTTAAAAAAGAGCAAGAAGTAAATGAAGAAGTACAAGAAATGACGGGGGAAACAGAGACTCAAGAGAAGAGTGATGAAATCACACGTGGTGTAAAGCGGAGAGCATCATCAGCATTCAGTGATGATGGGGAAGAGTTCAAAGGCTTTGATCAATGTGAGCAGAGCAGTCTAGATGACTACAACAAAATTGTTGAGGCGAGAAGAGTTAAACAGAGAACCTCCAGTGATAATGATGGTTTCAAAGGTTTTGACCTTATTGGGCATAACAACCTGACGGGATATTGTCAGGTTTTAGAACGCCTGGAAGCTGAAGTTTCTGCAGCGGCTAAGTCATTAACCCCGATTCGTCGTGTGATGACGACCCTGCGCAAACGCCAGAACACAGGTGGGTCTACCAAGTGGTCTGAACACCTGGAGGCGGAGGTGTCCGCTATGGTGAGGAGCTTCTCCACCGATGATGAGAGCAAAGGGAAAAGGCGGGCTGatggATCAAGACCATCATCAGCATTATCATCCAGATCCGATGGTGATGGCGCTACATCTACAGATGCATCATCATCTCCCGCGGGTCGGATCGGTCGTCGCGCCACTACGGAGATGTCATCACCTTTGCTAAGGATTCCTTTAGAGAAGGGATGGAAGCGAGAGCTGGTATATCGAGCAGCAGGTGCCTCTAGTGAAGTCCCTAGACGGAAtgcagatatatattattatgctcCTAGTGGAAAGAAGCTCAGATCTACTAGAGAGGTCTCCGAGCACTTGTCTGGCACTGGTCTCACATTAGAAAACTTCTCCTTCTTTAAAGAGCCTTTAGGAATTGATGACCCTGAGAAAGAAATAATAAGggaTGCAAAAGTTCAGACACGTCGCGTTGAGTCTCCAGTACCAGTCGCCGCGCCATCATTGGAGTCCAAGCGAACCCCTAAACCAAAGGCCCCTAAAGGAGCCAGCCCCGAGCCTGCCACCAAGTCCCCTCCTGCTAAATTAAAGGTGAAGTCAATGGGTTCCCGCCTTAGCAGCAATGGTACACCTGCGGCACCCAAGCAGATAAAGAAACCCAACACACCACAGACAGCAGTTACACCGGACAATAATAATTCAGCGGCCTGGAAAAAACCAAGGGGCCCGCCGCCGCTGCAGCCGCGGCCCGCGCATCCTGCGCAGCCCGTGCATCCCGCACAGCCAGCGCAGCAAGTGCATCCCACTCAGCCGGTGCATCCCACGCAGCCCGGTCACCCGGCGCTGCAGACACCCGCACCGCATCCCCCCCCACACACCGGAGCGGGACCCGCCGCCCGCTCTGCACCATCAGACTACTATATGCATCATCAGCGTCGTCAGGTGCAGCAGCCGTGCTCGATGACGTGCGGGGCGGGCGTGCCGTCGCTGGCGTGCGCAGCCTGTCTGTGCCTGTACCATCCCGCCTGCGTGGGACTTAGAGCGCCCTTGGACAGGTTCCTATGTAAGaaCTGCCGCAATACCTCGTCGCCACCACTAGAGCCGCCTCCCCTAACTCACAAGTCTGGTGTGACGTCACTGCCGGTCGGAAGGAGCGATAAACGAGTGCTTTTAAGAATGAagGTGGCTGGTGGTGGTCCAGACGGAGAACGTGTCTGGTCGGTCTCGAAGCCGGGCGCACCTCCCCCCTCTCCCCCGACTCCTACGCCGACCCCTGTCGCCCCCCACACCCCGGCACCCCTCACCGCCCCACCCGTCTGCCGGCCCTCCCTGCCGCAGTCGTTAGTCGTACTCAACGGGAGACGGTTCATAGTTGTAGCGAGAGCTATGCATCATGAGGTCAAGGTGACTCGTAGAGGCGTAGCCAATGGAGCCGCTTCCCCCCCTGCGCCCCCTGCAGCGCTGCGACGTAGCAGAGTCAAGCGCGATGACACTGATCACTTTACACCGTTCTACGAGAAGGCAAAGGAGAGCGGCTTGAATGTTGCCGTTCAGATCTTCCAGTACCTGGGTATGCGTGACGTGGCTCGTGCGGCGCGCGTGTGCTCGCTGTGGTCGCAGCTGGCGGCCGCGCCCGCACTGTGGAGGCACGTGCGGATGAAGAACTCGCATGTGAGCGAGTGGTCTGGTCTGTGTGCGTCACTGAAACGCCACGGCACGCGCTGGCTCGACCTCCGCAAGATGCTGCTCCCGCCCAACGACACGCTGTTTTGGGACCAATTCTCGGAGCACATCGGTACCGTCGACACACTCGAAAGGTTGGAGCTGTGTCGATGCCCCGCCCGCGCGGTGGAGGCGGCGTGTTCGCGGCTGCCTGGTCTGCGCGCACTGACCGCGCCCGCCATTCGGGACGCCAGGCTAGACCCCGCACCACTGGCAGCCCTGCCGCGACTAGAACTACTGCGCCTTAAGAGTCTAGCAGGTCTATCCTTGACGCGTGACCTGCGACCACTGGCCGCGCTATCTCGGCTGCAGCACCTGTCCCTCACCTCTATCAAGGAGCTGGGTTGGTGTGCCTGCGAGGTCGTGGGTCAGTTGGAACAGCTGGAGTCCTTGGAGCTGGGAGAGTGCTCTTTTGGCGGATCCTTCGCCAGTGCCCTCGGCAAGCTCGTCAAGTTGAGAAAATTGAGGTTGGAGCGAGGAGTGGCGCACTGTGCCGCGCCTGCGTTGTTGCGAGCTCTGGCAGCCCTGCCCAAGCTAACGCGATTAGAGCTAGTAAATTTTGACGTTAAGGTCGGATTCGACGATGCTCTAGCGGAATGCAAAAATATCCAGAGACTACTCATAATACCCACATATGTGTCACAATCCGCTACTACTAACAAACAGGTGTTGAGCGGAGTGCTGCGGCTGAAGGAGACGCTGACGCACCTCATGTGGGGCGTCACCATAGAACTACTGCGGGTCACGGAGCTGTTCATCGACCAGTGTGAAGCCGGCGACGGAGACAACAAGCGACGCGACGTGGGAGAGTGCATTCCCGTACTGAAACCAGTGCCGGGCTGCCGGCTGCCAGACGACCATCGCACCGTGGAAATCCTGCCCATTCCGACTCTACAGCGACTGTTGGCGGCTCAGTTGCCGCGCACTAAGCTCAAGCTTCTTCGGATCCCCTTCCACGCCACGTGGAGACAGTCGCTGGCGGACTTCCAATAG
Protein Sequence
MIILAKLEVCICLLTDDIEEQPEVKIEPEEKEDDNDEVKKEQEVNEEVQEMTGETETQEKSDEITRGVKRRASSAFSDDGEEFKGFDQCEQSSLDDYNKIVEARRVKQRTSSDNDGFKGFDLIGHNNLTGYCQVLERLEAEVSAAAKSLTPIRRVMTTLRKRQNTGGSTKWSEHLEAEVSAMVRSFSTDDESKGKRRADGSRPSSALSSRSDGDGATSTDASSSPAGRIGRRATTEMSSPLLRIPLEKGWKRELVYRAAGASSEVPRRNADIYYYAPSGKKLRSTREVSEHLSGTGLTLENFSFFKEPLGIDDPEKEIIRDAKVQTRRVESPVPVAAPSLESKRTPKPKAPKGASPEPATKSPPAKLKVKSMGSRLSSNGTPAAPKQIKKPNTPQTAVTPDNNNSAAWKKPRGPPPLQPRPAHPAQPVHPAQPAQQVHPTQPVHPTQPGHPALQTPAPHPPPHTGAGPAARSAPSDYYMHHQRRQVQQPCSMTCGAGVPSLACAACLCLYHPACVGLRAPLDRFLCKNCRNTSSPPLEPPPLTHKSGVTSLPVGRSDKRVLLRMKVAGGGPDGERVWSVSKPGAPPPSPPTPTPTPVAPHTPAPLTAPPVCRPSLPQSLVVLNGRRFIVVARAMHHEVKVTRRGVANGAASPPAPPAALRRSRVKRDDTDHFTPFYEKAKESGLNVAVQIFQYLGMRDVARAARVCSLWSQLAAAPALWRHVRMKNSHVSEWSGLCASLKRHGTRWLDLRKMLLPPNDTLFWDQFSEHIGTVDTLERLELCRCPARAVEAACSRLPGLRALTAPAIRDARLDPAPLAALPRLELLRLKSLAGLSLTRDLRPLAALSRLQHLSLTSIKELGWCACEVVGQLEQLESLELGECSFGGSFASALGKLVKLRKLRLERGVAHCAAPALLRALAALPKLTRLELVNFDVKVGFDDALAECKNIQRLLIIPTYVSQSATTNKQVLSGVLRLKETLTHLMWGVTIELLRVTELFIDQCEAGDGDNKRRDVGECIPVLKPVPGCRLPDDHRTVEILPIPTLQRLLAAQLPRTKLKLLRIPFHATWRQSLADFQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00461581; iTF_01034609; iTF_00960186; iTF_00959425; iTF_01033756;
90% Identity
-
80% Identity
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