Basic Information

Gene Symbol
-
Assembly
GCA_945859575.2
Location
OX243846.1:12660229-12683911[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 18 0.0001 0.011 17.2 0.1 3 23 134 154 133 154 0.97
2 18 9.4e-07 9.8e-05 23.6 1.2 1 23 160 182 160 182 0.99
3 18 5.8e-06 0.00061 21.1 2.7 1 23 188 210 188 210 0.99
4 18 3.9e-06 0.0004 21.7 2.6 1 23 225 247 225 247 0.98
5 18 9.3e-05 0.0097 17.3 0.6 1 23 262 284 262 284 0.98
6 18 5.3e-05 0.0056 18.1 3.1 1 23 299 321 299 321 0.98
7 18 3.7e-07 3.9e-05 24.9 1.5 1 23 336 358 336 358 0.99
8 18 0.00015 0.016 16.7 0.0 1 23 365 387 365 387 0.98
9 18 1.2e-05 0.0012 20.2 2.1 1 23 393 415 393 415 0.99
10 18 0.038 3.9 9.1 1.8 1 23 422 444 422 444 0.98
11 18 6.3e-07 6.6e-05 24.2 2.3 1 23 450 472 450 472 0.99
12 18 0.044 4.6 8.9 1.8 1 23 479 501 479 501 0.98
13 18 2.6e-06 0.00027 22.2 1.5 1 23 507 529 507 529 0.99
14 18 0.00049 0.051 15.1 0.7 1 23 536 558 536 558 0.99
15 18 2.8e-06 0.0003 22.1 1.9 1 23 564 586 564 586 0.98
16 18 0.0021 0.22 13.1 0.3 1 20 592 611 592 614 0.93
17 18 5e-05 0.0053 18.2 1.3 2 23 621 642 620 642 0.96
18 18 3.1e-06 0.00033 22.0 1.3 1 23 648 671 648 671 0.97

Sequence Information

Coding Sequence
ATGTTCGAACAGCAGATCAAGGCTGAACCTATGAGTTTTTACACAAATCATCCCCACGTTCACGCTGGTCCCCCCACAATAGTCCGATCAGATTCAAATCATGCAAGCATCATCAACATGAATCAGCATCATCAGACACATCAAGAGGATTCAAAAGACAGCCTCATAGTACAACAACAAGTACAACATCAACAAGATCTCATGGAACAACATCAGCAGCAACAAGAAATGCAACAAGACGATGAGTTAAGCTTCAAGGGTATGGAAGACGAAGGTGTTGAAATGGACATGGACGGTCGACAATGTTCTCAGGGTATGGGAGTGGACATGGGATCAGTTCAAACTAAAATGGAAGTGTCGAATGGGGGGCAATCGGCACCTCGTTCTAAGCCTCAAGCCTGCAAGGTTTGTGGTAAAGTCTTATCGTCCGCTTCTTCTTACTACGTCCACATGAAGCTTCACTCAGGAAACAAACCCTTCCAATGCACTGTTTGCGACGCAGCTTTTTGCCGTAAACCTTATCTGGAAGTCCACATGCGTACACACACGGGAGAACGTCCCTTTCAATGTGATCTCTGCCTCAAACGATTTACACAGAAATCAAGTCTGAACACGCACAAACGTGTCCATACAGATGAGCACATGCGCGCGTTGATGGTGAAGGAGCGGCCCTACAAGTGTGAACTCTGTCAGATGCGGTTCACGCAGAGCTCCAGCCTCAACCGACACAAGAAAATTCACACGGAGGAACACAAACGTGCGCTGCTGGCTAAACAACGGCCCTACCAGTGCGGCATCTGCTTTGTGAGATTCACCCAGAAATCAAGTTTGGGCCGGCACGGAAAAATACATACCGAGGAGCACAGACGAGCCCTGTTAGAGAAAGTGCGGCCGTACCAGTGCCACATCTGTTTTATGCGCTTCACTCAGAAGTCCAGCCTGGGACGACATGGGAAAATACACACTGAGGAGCACATCCAATCGCTGATCAACAAAGTGCGCCCCTATCAATGCGACATCTGTGACAAGCGGTTCACTCAGAAGTCCAGCCTTGGCACTCATAAACGCATACACACCGTGCAAGGGCGACCTTACGCGTGCGGGCAATGCCCGGCGGCGTTCGCCCGCCGCCCCTACCTGGACATTCACATGCGCACGCATACAGGCGAGCGGCCCTATCAGTGCGACGCGTGTCTCAAGCGCTTCACGCAGAAGTCCAGCCTCAATATACATAAGAGGACGCACACAGTCCAGGGCAGACCGTTCCAGTGCCTGTCGTGCCCCGCCGCCTTCACCTGCAAGCAATACCTGGAGATACACACGCGCACCCACACCGGCGAGCGGCCGTATCAGTGCGACATCTGCCTGAAGCGCTTCACGCAGAAGTCCAGTCTCAACATTCACAAGCGGACCCACTCAGTGCAGGGCCGCCCGTTCCAGTGCCTGCAGTGCCCCGCCGCCTTCACCTGCAAGCAGTACCTCGAGATACACAACCGCACGCACACCGGCGAGCGGCCCTACCAGTGTGACGTATGCCTCAAGAGATTCGCGCAAAAATCTACACTCAATATACACAAAAGAACGCACACAGTGCAAGGACGGCCGTACCAATGTATGGAGTGCCCGGCGGCGTTCACTTGCAAGCCGTACCTGGAGATTCACATGCGCACACACACGGGTGAACGTCCGTTCGAGTGCGATGTCTGTTACAAACGCTTCACGCAGAAATCCACGCTCAACATTCACAAGCGAATTCATACCGGTGAACGCCCATATGCTTGTGATATTTGTCAAAAAAGATTCGCTGTGAAAAGCTATGTAACAGCACACAGATGGTCGCACGTGGCGGACAAGCCGCTGAACTGCGACCGCTGCTCGCTGACGTTCACGTCCAAGTCGCAGTTCGCGCTGCACATCCGCACGCACTCCACCGGCTCCTGCTACGAGTGCAGCGTGTGCGGACGATCCTTCGTCAGGGACAGCTATCTTATAAGGCACCACAACCGCGTGCACCGCGAGAACCACAGCAACATGTCAGCGAACAGCATGGGGACATCGCTTGCTACCAACACCAATAACTCGAATAACGGCAACTATGACTCCCCTGGCGTTTGTGACTTAAGCTTCGTACCAATGGTGAATCGCTACATGACATCCCAAGGAACGCAGGTGTCCATGCAAGATACCAAAATGTCAGCGATGTCGCCGCAGTCTATCGCGTCTATTTCGTCGCCCCCTCCCTCGCATACTCCTACGCCCCAACCCCAGATGTCTGGTCAGCTACATCTTGCAGACTGA
Protein Sequence
MFEQQIKAEPMSFYTNHPHVHAGPPTIVRSDSNHASIINMNQHHQTHQEDSKDSLIVQQQVQHQQDLMEQHQQQQEMQQDDELSFKGMEDEGVEMDMDGRQCSQGMGVDMGSVQTKMEVSNGGQSAPRSKPQACKVCGKVLSSASSYYVHMKLHSGNKPFQCTVCDAAFCRKPYLEVHMRTHTGERPFQCDLCLKRFTQKSSLNTHKRVHTDEHMRALMVKERPYKCELCQMRFTQSSSLNRHKKIHTEEHKRALLAKQRPYQCGICFVRFTQKSSLGRHGKIHTEEHRRALLEKVRPYQCHICFMRFTQKSSLGRHGKIHTEEHIQSLINKVRPYQCDICDKRFTQKSSLGTHKRIHTVQGRPYACGQCPAAFARRPYLDIHMRTHTGERPYQCDACLKRFTQKSSLNIHKRTHTVQGRPFQCLSCPAAFTCKQYLEIHTRTHTGERPYQCDICLKRFTQKSSLNIHKRTHSVQGRPFQCLQCPAAFTCKQYLEIHNRTHTGERPYQCDVCLKRFAQKSTLNIHKRTHTVQGRPYQCMECPAAFTCKPYLEIHMRTHTGERPFECDVCYKRFTQKSTLNIHKRIHTGERPYACDICQKRFAVKSYVTAHRWSHVADKPLNCDRCSLTFTSKSQFALHIRTHSTGSCYECSVCGRSFVRDSYLIRHHNRVHRENHSNMSANSMGTSLATNTNNSNNGNYDSPGVCDLSFVPMVNRYMTSQGTQVSMQDTKMSAMSPQSIASISSPPPSHTPTPQPQMSGQLHLAD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00010401;
90% Identity
iTF_01425309;
80% Identity
-