Htar021382.1
Basic Information
- Insect
- Herminia tarsipennalis
- Gene Symbol
- gpkow_2
- Assembly
- GCA_945859575.2
- Location
- OX243845.1:15359930-15392850[-]
Transcription Factor Domain
- TF Family
- PAX
- Domain
- PAX domain
- PFAM
- PF00292
- TF Group
- Helix-turn-helix
- Description
- The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 4 0.011 24 5.9 0.1 23 80 510 567 502 600 0.85 2 4 0.00088 2 9.4 0.1 18 88 640 710 626 734 0.86 3 4 0.0024 5.2 8.0 0.0 18 77 775 834 761 851 0.85 4 4 0.00043 0.97 10.4 0.0 22 79 920 977 915 1021 0.79
Sequence Information
- Coding Sequence
- ATGGAAGGCAATAAGATCTCGTTTGGTTTTAAGAAAACTAAGAAAGCCGATAAACCTGTAGCTGTAAACAATGATGAAAGAAAAGAATACATAGAATGTGTAGAAGAACAATCTATCAAAGTTGTCGGTGGAGAAACAGAAGAAACTAATGAACCACTGGTCATACCTATGAAACCTAATTCACTTATAACTTCTGAAAGATTGATGGAAATTGCGCTGAAGGTTGAAAGTGCACTAGAAGAGCCAGAAATTAAAACTGAATCAGTAACTATTAAAATGGAAGACCCGTTAGGAGAAGAGAATGAAACATTGGATCAAATGGCAGAACGTGAACTGATGCAGGAGGCTCAAAAAGAAATTGTAACAGTCACACCTACAACAGAGATACCAACATCTACTAAGGGTGTTGCCGGAGGAGAAAAAGAGAAAGCAAAAGCCCTCATGAAGGACACCGTTGTCCTTCTATTAGATTTAATAAGTCAACAAAGAGTCATCACTACAAAAGGAACTGACGCTACAACTAACAGACTGAAGGAAGATGCTTGGAAAACGGTAGCCGAGGAATTCTGCACATTAACCGGTGAAATCCGGCGCCCTGATCAATTGCGCCTCAAATGGGAGAACTTAAAAAAGGCTGCCAGAAAGCGTTGTGCTTTAATTAAACAAAATAATGTTAAGGCAAAAGGACGAAAGTCATTTATTCCACCAAACGAGGTACTTGACAAAGTAGCAGCATTGCTAGGTGCTACTAGTGACTATGCAGCGGAGTTTAGTGAAGAAAGTAGAAATGAGGTTGATCTAGACCAAACAAGCTCTGAAGCTATGGTTGATGCCATAGAGCACCAGCCAATGCCAGGAAATCCTCCAATATCTCAATACCTTGGTGTGGAGTTGGATGTATCTAGTGATGTGGCAACTTTTACATCATCACCACCCAAATTTGTATTCAATGCGCCAAGAAATTCATATAATAAACGAAGGAAACTGTCGGAAGACCTCCTAAAGGCTAAAACAGATAAGGAGCTTGCCATAGCTGCTTACTTCCTAGCCCGAACAGAAAAAACTAAACTAGAAAATAAAAAATTGGAATTAGAAATAAAATCCACCTTAGATGATTATGAAGCTATTCCGGTGAAAGATTTTGGTGTTGCAATGTTACGAGGCATGGGATGGAAGCCGGGCCAAGAAGGATCTAAATACAAGCAACCAGAACTTCGTCCTAAAGGTCTTGGATTGGGGGCAGATAAAGTAGTGAAAGCGAAACAACAAGCATCGAAAGACTCCAAACCTGAAGAATTGGTCATTTTGAAGAACTCCTACGTGAAAATTGTTAGTGGGAAATATAGCGACTACTATGGCAAGGTAGTCAGCTTAGATGAAGATAATGGGCGAGTGGTCGTGGACATCCCCGTGAAGAAAGAAATGGTCAGTCTCAGCGAATTCATGATGAATGCTGTAACCAAGTCTGAATACGACAGAGAATCTAAAGTTATAAGGCCTCCTAAAGTGCGCGTGAGTGTTGATAAAAAACAAGAAATAATTAAAATGCACAAGAAAAAAATCCCCATAAGTGATATTGCAAGAGAACTGAAAATAGCGCGAAATACTGTGTACTTATGGATAAAACGTTGGGAAAAGGAAGGTGTTGTTAACGCCCATGGATCAACGGGTCGTCCATGCAAACTATCCGCTAATAAAAAAGCTCTTTTAATGAATGAAGTTAAAGAAACGGAGCTTAGTGTCTCAGACTTAGCGAGTAACCATGGTGTATCTACTGCAACCATTCGTCGATGTTTAAAAGACACTGGAGTCCGATGCAAAAGAAAAAAAAGGCCAATAACTGAACCTATAATTGAAATAGAAGTGCCAATAAAACAGGAATCAGATGGTATAAATATAGATTCTAAGAAGTTACGCTTAACTGAACATAAGAAGGAAAGAATTATTGCTTTGTATAAGCAAAAACATTCTACATCAGCTATTGCGAGGCACTTGAATGTCACGCGACAAACTGTGAACCTATGGATAAAACGTTGGAAAAAGGAAGGTGTTGTTAACGCTCATGTATCATCCGGCCGTCCATGCAAACTATCCGCTAATAAAAAAGCTCTTTTAATGAATGAAGTTAAAGAAACAGAGCTTAGTGTCTCAGACATAGCGAGTAACCATGGTGTATCTACTGCAACCATTCGTCGATGTTTAAAAGACACTGGTGTCCGATGCAAAAGAAAAAAAAGGCCAATAACTGAACCTATAATTGAAATGGAAGTGCCAATAAAACAGGAATCAGATGGTATAAATATAGATTCTAAGAAGTTACGCTTAACTGAACGTAAGAAGGAAAGAATTATTGCTTTGTATAAGCAAAAACATTCTATAACGGCTATTGCGAGGCACTTGAATGTGACGCGAAACACAGTCATGCTATGGGTGAAGCGTTGGAAAAATGAAGGCGTTATTAATCAACATTCGTCAGGTGGTCGTCCATCAAAACTATCTTCAAATGCTGGAGCTCTTTTAATAAAACAAGCCACCCAAGCAGACGATGTTAATTTATCAGAACTTGCAGCCACCCATGGTGTCTCAGTAAGCACAGTTCGAAGGCACTTAATACAAAACGGAATACCATACAAAAAAAAGGAAAGAAAAATCGGTGTTAGAACGAGAAAGGAAGTTCCTAAGTCAGCTGTTGATGATGATATAGGATATGAGGGCATTCATGAACCAAAAAAGGCTGCATACCATATTAATGTTGATAAGAGGCAACAGATTATACTTTTACATGAACAAAAGCATTCTGTGAGTGCTATTGCAAGATATTTAAATATATCGAGAAACACCGTCAATTTATGGATAAGACGATGGAAAGGCGAAGGCTCTATCAACCCACATTTACCAAGCGGTCGTCCACGCAAACTATCTTTAAATCAAGAAGAAATTTTGATAGAACACGCGAAGGAAGCTGAAAAACTTGGCACGTCAAATCTTGCGTCTTGTTTTGGCGTCTCAACAGCTACCATTCGACGACGTTTATGTGCTAATGGACTCAAGTCAAAGTCTAATAAAGAAGAAGAACAAATATAG
- Protein Sequence
- MEGNKISFGFKKTKKADKPVAVNNDERKEYIECVEEQSIKVVGGETEETNEPLVIPMKPNSLITSERLMEIALKVESALEEPEIKTESVTIKMEDPLGEENETLDQMAERELMQEAQKEIVTVTPTTEIPTSTKGVAGGEKEKAKALMKDTVVLLLDLISQQRVITTKGTDATTNRLKEDAWKTVAEEFCTLTGEIRRPDQLRLKWENLKKAARKRCALIKQNNVKAKGRKSFIPPNEVLDKVAALLGATSDYAAEFSEESRNEVDLDQTSSEAMVDAIEHQPMPGNPPISQYLGVELDVSSDVATFTSSPPKFVFNAPRNSYNKRRKLSEDLLKAKTDKELAIAAYFLARTEKTKLENKKLELEIKSTLDDYEAIPVKDFGVAMLRGMGWKPGQEGSKYKQPELRPKGLGLGADKVVKAKQQASKDSKPEELVILKNSYVKIVSGKYSDYYGKVVSLDEDNGRVVVDIPVKKEMVSLSEFMMNAVTKSEYDRESKVIRPPKVRVSVDKKQEIIKMHKKKIPISDIARELKIARNTVYLWIKRWEKEGVVNAHGSTGRPCKLSANKKALLMNEVKETELSVSDLASNHGVSTATIRRCLKDTGVRCKRKKRPITEPIIEIEVPIKQESDGINIDSKKLRLTEHKKERIIALYKQKHSTSAIARHLNVTRQTVNLWIKRWKKEGVVNAHVSSGRPCKLSANKKALLMNEVKETELSVSDIASNHGVSTATIRRCLKDTGVRCKRKKRPITEPIIEMEVPIKQESDGINIDSKKLRLTERKKERIIALYKQKHSITAIARHLNVTRNTVMLWVKRWKNEGVINQHSSGGRPSKLSSNAGALLIKQATQADDVNLSELAATHGVSVSTVRRHLIQNGIPYKKKERKIGVRTRKEVPKSAVDDDIGYEGIHEPKKAAYHINVDKRQQIILLHEQKHSVSAIARYLNISRNTVNLWIRRWKGEGSINPHLPSGRPRKLSLNQEEILIEHAKEAEKLGTSNLASCFGVSTATIRRRLCANGLKSKSNKEEEQI
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00794508;
- 90% Identity
- iTF_00794508;
- 80% Identity
- iTF_00794508;