Basic Information

Insect: Heliconius himera
Gene Symbol: MBD-R2_1
Assembly: GCA_013421065.1
Location: JAATLT010025274.1:11895-27298[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.9e-15 3.5e-11 42.7 0.1 5 61 729 784 725 821 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.9e-15	3.5e-11	42.7	0.1	5	61	729	784	725	821	0.90

Sequence Information

Coding Sequence: ATGGCAGTAAAAAGATGTTGTGTAGAAAACTGTAATTCTTCCTCAACAAGATTAGAAGATATCGGTGTAACATATCACAAATTTCCTAAAGACACAACATTACGTGAAACATGGGTGTCTGCTACACATGTGCACACTAATATAGATTCTTATACTTATGTGTGCTCACGGCATTTTTGTAAAAGTGATTTTCAATCTTATCAAGACTCGAAATATATGTTGAAGTCAGatgCTGTACcatcaatatttatatggaataaaaaaaacaattctaatattaaaatggagTCAATAGTATCAGATGAAATAACTAATGAGAAACAAAATACATCTTCAAGTAGTAAGGAATCTGATGGGGAAAACTTAGAAGCCATAAGGAGATTCATAGAGGATCAGGAGAAGGAGATTCAAGAGTTAGAAAAAGACAAAAATGGAGGAAAACCAGGAAATACTAGCGAAATaagaaataaggaaataatGGAGGTTATTGAGCCAGGGGAACCAATGGTGATTGCGACTAGTGTAATTAATATGATCTTAAGTGAATCAGAAGCTAAAATAGCGAGTGCTAATATGAAAAAGTTGCCTAAACATCAATTAAGTCATAGAGACAAAGgtTCTCCTCCTTCCAGCAGTGGTAGTATGTCTCTAACTGTAGGCTCCAAAGTAGAAGCAAAAGATTTCAGTGATTTCTGGTATTCCGCTGAGATCATTGAAGTGGACTATGATGAGATGGAAGTTTTGTTGCATTACGACAAGGTTTATAACAAacatGACGAATGGATCAGTGTGAACAGTCCTAGATTACGACCGTACACTAGAACATCTAGACCGATATCCCCTCAACCGTCAACTTCAGAAGAGACCGAGATGAAAGAAGATAAAACAGAtgaaaaaactaaagaaaaactgAAGTTTATAGTAGGAGAGAGATGTTTAGCTCGATGGCGGGATAATAGGCGATTTGTTGCTACTATTAGTAACGTTTTGAGCaatgGTCATTACGAAATAATATTCGATGATGGATTCCAATGGAAGTGTAGCAAATCAAGACTATACAAATTAAAGGATTCAAAACAAGAACTCTCTATAGATACGTCGATGTCGCCAACGCCTTCTACCCCATCCCCTATACTTATTGAAGCCGGACCCAGTACGAATATGAATCCCACAACACCTATATACCATACACATCTGTTTGATCCTACAAGAGATTATTTAGGTTCTAAAAGTGAAAGAAGGGAAATGAaaagaaagttaaatattaaagagatatttaatattggaCAAAAGAAGCAAAGGAGGGACAAGTCGCTTGATAAAGAGAAGTTAGAGAAGCCCAAAGTTTTTAAGAAGAAGCTTAAGCCAGTAGAAGTTAATAGTgaaattaaaatggaaatacctgatgcTGTAGCGTCAATAATAGGCACTGTAGCCAAAGAACTTGATTCACCACAAACACCTGATTTGCCACAAGaggatataaaagaaattattgaagttaaaaaggaaaatatacaaGCAGATGAAATTATTCAGGAAGAAAATACAGAGAATAAGAAGGAAATAACAGAAagtattgaaaatgaaaatactccATCGTTAGAAGAAAATAGTGATCTATTGGAACCTAGTGATTTGGGTATTGAAGTTAAAAACGAATCTGTTATtgaagaagaaatgaaactgGAACAATTTGAAAAGCCCGACGACAGCAAAAAAGAAGTGATAGAAAAAATGAAAGAAGTCATAACGAAACTAGAGGATGGCTTGAACGAAATGGAAAAAGTCAATTCACCTAAACCcgaattgataataaaattgaagcAAATCAAATGTGATCtcgtaaaagaagaaaaaaccccagagcaagaaaagaaaaaagcgccaaaaataaagaaaaataaaaaattgagattGTTACAGGAGAAGAAAGTGAAGAAACAAGTAGATAAAGTTAAAAGTGAGTTGGCTGAAATGAAAAAGCAAATGGAGGAGATGAGAAAGGAAATGCTGCTGAAGACTGAGGAGTTGTCGATGGCGCGGCCTAAGGAAATGCCGGAAAGTTTCCTTTTGCCTGGAGAATGGTGCTGTAAGTGGGTGGACGGACAGCCAGTGGGCACTGTCACTGATATAGAAGTTGATACCAAGGATGGTAGCCAAGTTTTGCTTAGACGGAGTGTGCAGGTAGAAGATAAAAGGTTACCTCCAGGATGGACCAAGCTCATGGTGCGTCGAAGTATGGGACAGTCTGCCGGAAAATGGGATGTTGCATTAATAgggCCTGATAACCGCCGTTTTCACACCAAAACGGACATGCGCAACTATTTGGAACAAAACAAAGATGAGAGTTTAACATCATATGAATCAGCATTGATGGACTTTGGTGTGCATCTAAAGTTGTCCCGACGTATGGGATGGGTGGTCGGCGGGAAACCCCTGTCCAGCAAAAAGAGGAAAGAAGAGAGAAAAGAGAAGAGAAAGAGAAAGAAACTGGCGAAAcgCCTTTCTTTGACCGAGACGCCTGGCCCAAGTCAAGTTTATATGGACCCGATAGATATGTTTGTTGATATGCCCATTGAGAATCCTACTTTAGAAGATGGTTACGTATATGTCGGATCGCTCAAGGTCCAGATCATCGAGAACCTTCTGCGATGTCCAGCTGAAGGTTGTTACAAAAACTTTAGAAATAACACTCTTCTGCAAATGCACATAAAGCACTACCATCCCGAACTAAGAGAAATGTTAGGAGCTACACCAAAAGTTTTAGATTTGGCCCAAGAAAGAACCAAACCAACTGACTTGGAACCGAAACCACGTTACGAACCAGAATCTAAGATAATCAAAGTTAAAATACCGCGACCACCCAAGAAGGTTGAGGAACCGAAACCGGAACCAAAGGAACCGGTTCCCGAACTACAAATAGACACTGCGGTGCCGATACCCGAGCCAAGACCTCAAGATTCACCGAAATTGAGACAGGCTTTAGTGAATAAACCTGTGAAACGACCAAAAGTTCTTTTACCTGTTAGGAGAATAAACCCAGAAATACAAGAACCCATAGAAGAACCCATGAACATGGACGTAGCAATGGAAACAGAAATCGAACAAGATACCTCGGTGGACTTTGAAATGGAGATATCTCCTCATACAGTGCCAAAACCCGTAGATGATAAGAGGAAAGTGATAATTGATAAGAAACGTAGATGCTTCCCGTCAGCTAAGAGACCTTTGAGTGAGGAGGATGAGTGGTATACGGTGAATTCAGATTTTGAAACTAGATCTAGTTTTCCTGGTTCGGGCACACCTGATTCTAAAACAATGGACAAGAGTAATCAAGCGGTGTATGAATCGAATGAAGAACGAAAGGAttctaatatgtatatgtatactgaaaCGGGTGAACGTATCAAGTTGGAGCATATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGCCTGATGGTGCAGTGCGAGCTGTGCCTCTGTTGGCAGCACGCTGTGTGCCATAATATACAAAAGGAGGCCGAGgtACCAGAGAAATATACCTGCAGTATATGTCTTAACCCGCGCAGAGGGCGGCGCTCCAAGCGTTTCCTTCACGACCAGGACAGGCTCTACGAGGGCTTGCTTCCAGGGGCGAAGCCCTGCGACTCATTGCGCAGGTCACACGAGCTATCAGGGAATCTACTCAGGATTCAAGATGCTCTTCATGCATTACGAGTGAAATATTATGTTGCTACtaAAAAAGACCACCCTAAATTATACCTCTGGGCCAAAGACTGGGAGAATGCGGAAATCACGTACACGCAAGAACGTCTCAACTCAGATTATTCAGATctcaacattataataaataatatagGTAAAGAGAACTTACCAGTGAAACCTGAAGAAATAAAAGATGCTCATTTAGATGTAAGAATGCCGCTGACAGAAGATCCCGATCAAGAGAGAATGCTCGGTCTCAACACGGGCTTGTCAAGTCCGAGCGGCACTTCCTTAGAGTTGCCTATATCCACTTTGGAATTGGAAAGATTCGCCAAATCTGTACAAGaGCAAGAgccgccgcgcgcgcccgccgcgccgcagCCCGAGGCGGCCATCGAGGACGGCGCGTGCCGCGAGCGCCTGCTGCGCCACGTGCAGCGCTGCCAGGCGCTCATCGACGCGCGCCTCGACTCCATCGAGGCGCAGATTGCGGAATTAGAGTCTCAAGATCCATCATTCGAAGACGATGAAACGGCGGATTACTTTCCGAGAACCAAACAAACGATACAAATGCTCATGCGTGATCTTGACACTATGGAAGAGCTGGGCATTATTACGTAG
Protein Sequence: MAVKRCCVENCNSSSTRLEDIGVTYHKFPKDTTLRETWVSATHVHTNIDSYTYVCSRHFCKSDFQSYQDSKYMLKSDAVPSIFIWNKKNNSNIKMESIVSDEITNEKQNTSSSSKESDGENLEAIRRFIEDQEKEIQELEKDKNGGKPGNTSEIRNKEIMEVIEPGEPMVIATSVINMILSESEAKIASANMKKLPKHQLSHRDKGSPPSSSGSMSLTVGSKVEAKDFSDFWYSAEIIEVDYDEMEVLLHYDKVYNKHDEWISVNSPRLRPYTRTSRPISPQPSTSEETEMKEDKTDEKTKEKLKFIVGERCLARWRDNRRFVATISNVLSNGHYEIIFDDGFQWKCSKSRLYKLKDSKQELSIDTSMSPTPSTPSPILIEAGPSTNMNPTTPIYHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKQRRDKSLDKEKLEKPKVFKKKLKPVEVNSEIKMEIPDAVASIIGTVAKELDSPQTPDLPQEDIKEIIEVKKENIQADEIIQEENTENKKEITESIENENTPSLEENSDLLEPSDLGIEVKNESVIEEEMKLEQFEKPDDSKKEVIEKMKEVITKLEDGLNEMEKVNSPKPELIIKLKQIKCDLVKEEKTPEQEKKKAPKIKKNKKLRLLQEKKVKKQVDKVKSELAEMKKQMEEMRKEMLLKTEELSMARPKEMPESFLLPGEWCCKWVDGQPVGTVTDIEVDTKDGSQVLLRRSVQVEDKRLPPGWTKLMVRRSMGQSAGKWDVALIGPDNRRFHTKTDMRNYLEQNKDESLTSYESALMDFGVHLKLSRRMGWVVGGKPLSSKKRKEERKEKRKRKKLAKRLSLTETPGPSQVYMDPIDMFVDMPIENPTLEDGYVYVGSLKVQIIENLLRCPAEGCYKNFRNNTLLQMHIKHYHPELREMLGATPKVLDLAQERTKPTDLEPKPRYEPESKIIKVKIPRPPKKVEEPKPEPKEPVPELQIDTAVPIPEPRPQDSPKLRQALVNKPVKRPKVLLPVRRINPEIQEPIEEPMNMDVAMETEIEQDTSVDFEMEISPHTVPKPVDDKRKVIIDKKRRCFPSAKRPLSEEDEWYTVNSDFETRSSFPGSGTPDSKTMDKSNQAVYESNEERKDSNMYMYTETGERIKLEHMKREEIINCHCGFREEDGLMVQCELCLCWQHAVCHNIQKEAEVPEKYTCSICLNPRRGRRSKRFLHDQDRLYEGLLPGAKPCDSLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWENAEITYTQERLNSDYSDLNIIINNIGKENLPVKPEEIKDAHLDVRMPLTEDPDQERMLGLNTGLSSPSGTSLELPISTLELERFAKSVQEQEPPRAPAAPQPEAAIEDGACRERLLRHVQRCQALIDARLDSIEAQIAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00775272;
90% Identity: iTF_00779560; iTF_00777391; iTF_00777423; iTF_00775316; iTF_00775272;
80% Identity: iTF_00779560;