Hcha001932.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Heliconius charithonia
Gene Symbol
MBD-R2
Assembly
GCA_030704555.1
Location
CM060809.1:30641954-30657781[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.4e-13 3.4e-10 39.9 0.2 5 58 686 739 682 790 0.90

Sequence Information

Coding Sequence
ATGGCAGTAAAAAGATGTTGTGTAGAAAACTGTAATTCTTCCTCAACAAGATTAGAAGATATCGGTGTCACATATCACAAATTTCCTAAAGACACAACATTACGTGAAAAATGGGTGTCTGCTACACATGTGCACACTAATATAGATTCTTTTACTTATGTGTGCTCACGGCATTTTTGTAAAAGTGATTTTCAATCTTATCAAGACTCGAAATATATGTTGAAGTCAGatgCTGTCCCATCAATATttgtatggaataaaaaaaacaattctaatattaaaatggacTCAATAGTATCAGATGAAGTAACTAATGAGAAACAAAATACATCTTCAAGTAGTAAGGAATATGATGGGGAAAACTTAGAAGCCATAAGGAGATTCATAGAAGATCAGGAGAAGGAGATTCAAGAGTTAGAAAAAGACAAAAATGGAGGAAAGCCAGAAAATACTAGTGAAATTAGAAATAAGGAAATAATGGAGGTTATTGAACCAGGGGAACCAATGGTGATTGCAACTAGTGTAATTAATATGATCTTAAGTGAATCAGAAGCAAAAATAGCGAGTGCTAATATGAAAAAGCTGCCAAAACATCACTTAAGTCCTAGAGACAAaggttctTCTACTTCCAGTAATAGTAGTATGTCTCTAACTGTAGGCTCCAAAGTAGAAGCAAAAGATTTCAGTGATTTCTGGTATTCTGCTGAGATCATTGAAGTGGACTATGATGAGATGGAAGTTTTGTTGCGTTACGACAAGGTTTATAACAAacaTGACGAATGGATCAGTGTGAACAGTCCTAGATTACGACCGTACACTAGATCGTCTAGACCGATTTCCCCTCAACCGTCAACTTCAGAAGTGACCGAGATGAAAGAAGACAAAACagaagaaaaaagtaaattgaaGTTTATAGTAGGAGAGAGGTGTTTAGCTCGATGGCGGGATAATAGGCGATTTGTTGCTACTATTAATAACGTTTTGAGCaatgGTCACTACGAAATAATATTTGATGATGGATTCCAATGGAAATGTAGCAAATCAAGACTATTCAAATTAAAGGATTCAAAACAAGAACTCTCGATAGATACAGATTATTTAGGTTCTAAAAGTGAAAGAAGGGAAATGAaaaggaagttaaatattaaagagatatttaatattggaCAAAAGAAGCAAAGGAGGGACAAGTCGTTTGATAAAGAGAAGCTAGAGAAGCCTAAAGTTTTTAAGAAGAAGCTTAAGCCAGTAGAAGTtaatagtgaaataaaaatggaGATACctgatGCTGTAGCGTCAATAATAGGCACTGTAGCTAAAGAACTTGATTCACCACAAACACCAGATTTGCcacaagaagaaaaaaaagaaattgtcgaagttaaaaaggaaaataaagaaGCAGATGAAATTATTAACGAAGAAAATACAGAGAGTAAGAAGGAAATAACAGAGAGTATTGTAAATGAAATGTTAGAAGGAAATAGTGATCTATTGGACCCTAGTGATTTGGGTATTGAAGTCAACAACGTATCTGTTATTGAAGAAGAATTGAAATTGGAACAATTTGAAAAGCCCGACGACAGTAAAAAAGAAGTGATAGAAAAAATGAAAGAAGTCATAACAAAATTAGAGGATGGCTTAAACGAAATGGAAAAAGTCAATTCACCTAAACCcgaattgataataaaattggaGCAAATCAAATGTGATCTCGTTAAAGAAGAGAAACCCCTAGagcaagaaaagaaaaaagggccaaaaataaagaaaaataaaaaattgagattGTTACAGGAGAAGAAAGTGAAGAAACAAGTGGATAAAGTTAAAAGTGAGTTGGCTGAAATGAAAAAGCAAATGGAGGAGATGAGAAAGGAAATGCTGCTTAAGACTGAGGAGTTGTCGATGGCCCGGCCTAAGGAAATGCCGGAAAGTTTCCTTTTGCCTGGAGAATGGTGCTGTAAGTGGGTGGACGGACAGCCAGTGGGTACTGTCACTGATATAGAAGTTGATGCCAAAGATGGTAGCCAGGTTTTGCTTAGACGGAGTgtgcagGTAGAAGATAAAAGGTTACCTCCAGGATGGACCAAGCTCATGGTGCGTCGAAGTATGGGACAGTCTGCCGGAAAATGGGATGTGGCCTTAATaggacCTGATAATCGCCGTTTTCACACCAAAACAGACATGCGGAACTTTTTGGAACAAAACAAAGATGAGGGCTTAAAATCATACGAATCAGCTTTGATGGACTTTGGTGTGCATCTAAAGTTGTCCCGACGTATGGGATGGGTGGTCGGCGGGAAACCGCCGTCGAGCAAAAAGAGGAAAGAAGAGAGAAAAGAAAAGAGAAAGAGAAAGAAACTGGCGAAAcgGCTTTCTTTGACCGAGACGCCTGGCCCAAGTCAAGTTTATATGGACCCTATTGATATGTTTGTTGATATGCCCAGTGAGAATCCTACTTTAGAAGATGGTTATGTATATGTCGGATCGCTCAAGGTCCAGATCATCGAGAACCTTCTGCGATGTCCAGCTGATGGTTGCTACAAAAACTTTAGAAATAACACCCTCCTGCAAATGCACATAAAGCATTACCATCCCGAACTAAGAGAAATGTTAGGAGCTACACCAAAAGTCCTAGATTTGGCTCAAGAAAGAACCAAACCGACTGACTTGGAACCGAAACCGCGTTACGAATCAGAATCTaagataataaaagttaaaataccgCGACCACCCAAGAAGGTTGAGGAACCGAGACCGGAACTAAAGGAGCCGGTTGCCGAACTACAAATAGACACTATGGTCCCGAAACCCGAGCTACGACCTCAAGATTCACCGAAATTAAGACAGGCTTTAGTGAATAAACCTGTGAAACGGCCAAAAGTTCTTTTACCTGTTAGGAGAATAAATCCAGAAATACAGGAACCCATAGAGGAACCCATGAACATGGACGTAGCAATGGAAACAGAGATCGAGCAAGATATCCCGGTAGActttgaaatggaaatatctcCTCATACAGTGATAAGACCCGTAGATGATAAGAGGAAAGTGATAATTGATAAGAAACGTAGGTTCTTCCCGTCAGCGAAGGGACCAATGAGTGAGGAGGATGAGTGGTATACGGTGAATTCAGATTTTGAAACTAGATCTAGTTTTCCTGGTTCGGGTACACCTGATTCTAAAACAATGGACAAAAGTAATCAAGCGGTATATGAATCGAATGAGGAACGAAAGGAttctaatatgtatatgtatactgaaaCGGGTGAACGTATCAAGTTGGAGCATATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGACGGGCTGATGGTGCAGTGCGAGCTGTGCCTCTGTTGGCAGCATGCGGTGTGCCATAATATACAAAAGGAGGCCGAGgTACCAGAGAAGTATACATGCAGTATATGTCTCAACCCGCGCAGAGGGCGGCGCTCTAAGCGCTTCCTTCACGACCAGGACAGACTCTACGAGGGCTTGCTTCCGGGGGCGAAGCCCTGCGACCCCTTGCGCCGGTCACACGAGCTATCAGGGAATCTACTCAGGATTCAGGATGCTCTTCATGCATTACGAGTGAAATATTATGTTGCTACTAAAAAAGACCACCCGAAATTATACCTCTGGGCCAAAGACTGGGAGAATGCGGAAGTCACCTACACGCAAGAACGTCTCAACTCAGATTATTCAGATctcaacattataataaataatatagGTAAAGAGAACTTACCAGTGAAACCTGAAGAAATAAAAGATGCTCATTTAGATGTAAGAATGCCGCTGACAGAAGATCCCGATCAAGAGAGAATGCTCGGTCTCAATACGGGcttgtcaagtccgagtggtaCATCCTTAGAGTTGCCTATATCCACTTTGGAATTGGAAAGATTCGCCAAATCTGTACAAGAGCAAGACCCTCCCCGCGCGCCCGCCGCCCCGCAGCCCGAGGCGGCCATAGAGGACGGCGCGTGCCGCGAGCGCCTCCTGCGCCACGTGCAGCGCTGCCAGGCGCTCATCGACGCGCGCCTCGACTCCATCGAGGCGCAGATTGCGGaATTGGAGTCTCAAGATCCATCATTTGAAGACGATGAAACGGCGGATTACTTTCCAAGAACCAAACAAACTATACAAATGCTCATGCGTGATCTTGACACTATGGAAGAGCTGGGCATTATTACGTAG
Protein Sequence
MAVKRCCVENCNSSSTRLEDIGVTYHKFPKDTTLREKWVSATHVHTNIDSFTYVCSRHFCKSDFQSYQDSKYMLKSDAVPSIFVWNKKNNSNIKMDSIVSDEVTNEKQNTSSSSKEYDGENLEAIRRFIEDQEKEIQELEKDKNGGKPENTSEIRNKEIMEVIEPGEPMVIATSVINMILSESEAKIASANMKKLPKHHLSPRDKGSSTSSNSSMSLTVGSKVEAKDFSDFWYSAEIIEVDYDEMEVLLRYDKVYNKHDEWISVNSPRLRPYTRSSRPISPQPSTSEVTEMKEDKTEEKSKLKFIVGERCLARWRDNRRFVATINNVLSNGHYEIIFDDGFQWKCSKSRLFKLKDSKQELSIDTDYLGSKSERREMKRKLNIKEIFNIGQKKQRRDKSFDKEKLEKPKVFKKKLKPVEVNSEIKMEIPDAVASIIGTVAKELDSPQTPDLPQEEKKEIVEVKKENKEADEIINEENTESKKEITESIVNEMLEGNSDLLDPSDLGIEVNNVSVIEEELKLEQFEKPDDSKKEVIEKMKEVITKLEDGLNEMEKVNSPKPELIIKLEQIKCDLVKEEKPLEQEKKKGPKIKKNKKLRLLQEKKVKKQVDKVKSELAEMKKQMEEMRKEMLLKTEELSMARPKEMPESFLLPGEWCCKWVDGQPVGTVTDIEVDAKDGSQVLLRRSVQVEDKRLPPGWTKLMVRRSMGQSAGKWDVALIGPDNRRFHTKTDMRNFLEQNKDEGLKSYESALMDFGVHLKLSRRMGWVVGGKPPSSKKRKEERKEKRKRKKLAKRLSLTETPGPSQVYMDPIDMFVDMPSENPTLEDGYVYVGSLKVQIIENLLRCPADGCYKNFRNNTLLQMHIKHYHPELREMLGATPKVLDLAQERTKPTDLEPKPRYESESKIIKVKIPRPPKKVEEPRPELKEPVAELQIDTMVPKPELRPQDSPKLRQALVNKPVKRPKVLLPVRRINPEIQEPIEEPMNMDVAMETEIEQDIPVDFEMEISPHTVIRPVDDKRKVIIDKKRRFFPSAKGPMSEEDEWYTVNSDFETRSSFPGSGTPDSKTMDKSNQAVYESNEERKDSNMYMYTETGERIKLEHMKREEIINCHCGFREEDGLMVQCELCLCWQHAVCHNIQKEAEVPEKYTCSICLNPRRGRRSKRFLHDQDRLYEGLLPGAKPCDPLRRSHELSGNLLRIQDALHALRVKYYVATKKDHPKLYLWAKDWENAEVTYTQERLNSDYSDLNIIINNIGKENLPVKPEEIKDAHLDVRMPLTEDPDQERMLGLNTGLSSPSGTSLELPISTLELERFAKSVQEQDPPRAPAAPQPEAAIEDGACRERLLRHVQRCQALIDARLDSIEAQIAELESQDPSFEDDETADYFPRTKQTIQMLMRDLDTMEELGIIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00775316; iTF_00779521; iTF_00779560; iTF_00777391; iTF_00777423; iTF_00457252; iTF_00457294; iTF_00774509; iTF_00774548; iTF_00780271; iTF_00780307; iTF_01181907; iTF_01181947; iTF_00781850; iTF_00781891;
90% Identity
iTF_00779521;
80% Identity
iTF_00775316;